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Novavax's protein-based COVID vaccine induces broad functional immune response against XBB subvariants, data shows

Novavax, Inc., a global company advancing protein-based vaccines with its novel Matrix-M™ adjuvant, today announced that its updated protein-based XBB COVID vaccine candidate induced neutralizing antibody responses to the EG.5.1 and XBB.1.16.6 subvariants in small animal and non-human primate studies.

25 Aug 2023

FDA approves more drugs based on single trials and less public disclosure of results

The U.S. Food and Drug Administration is approving more novel pharmaceutical drugs based on single clinical trials and with less public disclosure about those trials than was the norm just a few years ago, a pair of recent studies from Oregon State University found.

24 Aug 2023

Small molecule inhibitor of the NLRP3 inflammasome for treating autoinflammatory diseases

Researchers described the preclinical profile of JT002, a novel and orally bioavailable small molecule inhibitor of the NLRP3 inflammasome.

24 Aug 2023

Stowers researchers reveal why certain anti-cancer drugs can cause unexpected side effects

With around 90% of drugs failing to make it to market, the potential for improving efficiency within the drug development industry is clear. Drugs designed to combat cancers suffer similar rates of failure for many reasons.

23 Aug 2023

Project NextGen awards over $1.4 billion to develop the future of COVID-19 vaccines and therapeutics

Funding includes $1 billion for vaccine clinical trials, $326 million for a new monoclonal antibody, and $100 million to explore novel vaccine and therapeutic technologies.

23 Aug 2023

Aspirin underutilized for preventing heart attack, stroke

For people who have experienced a heart attack or stroke, taking a daily aspirin has been shown to help prevent a second one.

22 Aug 2023

Researchers decipher the mode of action of new antibiotic

More and more bacterial pathogens are developing resistance. There is an increasing risk that common drugs will no longer be effective against infectious diseases.

22 Aug 2023

Aspirin adherence after heart attack linked to lower risk of recurrent heart attack, stroke, death

Heart attack patients who do not take daily aspirin have an elevated likelihood of recurrent myocardial infarction, stroke or death compared with those who consistently take the drug, according to research presented at ESC Congress 2023.

22 Aug 2023

Study explores mechanism behind liraglutide-associated weight loss in obese individuals

A new study suggests that liraglutide is associated with the normalization of associative learning in obese individuals with insulin resistance.

22 Aug 2023

Study finds no link between short-term immunosuppressant use and cancer

Relatively short-term use of immunosuppressant medications to control an inflammatory disease was not associated with an increased risk of later developing cancer, according to new research led by scientists at the University of Pittsburgh and Mass Eye and Ear, a member of the Mass General Brigham health care system, and published today in the journal BMJ Oncology.

21 Aug 2023

New DNA-based anticoagulant could treat heparin-induced thrombocytopenia

Various medical circumstances, including heart attacks and extreme cases of COVID-19, necessitate the use of anticoagulants, medicines that prevent blood clots

21 Aug 2023

COVID-19 associated with increased risk of developing various autoimmune diseases and risk could be attenuated by vaccination

COVID-19 can increase the risk of various autoimmune diseases; however, this risk appears to be mitigated by vaccination against COVID-19.

21 Aug 2023

Common genetic variants reduce clopidogrel effectiveness in British South Asians

Clopidogrel is a commonly prescribed medication used to prevent further heart attacks after an initial event. It needs to be activated in the body to be effective.

21 Aug 2023

A hybrid approach to re-engineer a SARS-CoV-1 neutralizing antibody against SARS-CoV-2

A hybrid approach involving a combination of conventional discovery and antibody repurposing to combat COVID-19.

21 Aug 2023

The standard of care and recent advancements in the control of skin inflammation

Researchers discuss current therapeutic interventions for atopic dermatitis in children and adolescents.

21 Aug 2023

Proxalutamide shows promise as potential COVID-19 treatment

At the outset of the COVID pandemic, men appeared to suffer higher rates of severe illness and death, leading researchers to suspect a link between androgen receptors - which bind to hormones like testosterone--and SARS-CoV-2 viral infection.

18 Aug 2023

A peek at Big Pharma’s playbook that leaves many Americans unable to afford their drugs

America's pharmaceutical giants are suing this summer to block the federal government's first effort at drug price regulation.

18 Aug 2023

Phase I trial shows promise: Brain stimulation spurs upper-extremity recovery in stroke patients

Researchers performed an open-label phase I trial.

18 Aug 2023

New findings could develop effective vaccines or treatments for chikungunya fever

Researchers at Albert Einstein College of Medicine have found that the virus responsible for chikungunya fever can spread directly from cell to cell - perhaps solving the longstanding mystery of how the virus, now emerging as a major health threat, can manage to escape antibodies circulating in the bloodstream.

18 Aug 2023

New method to assess the status of immune responses to specific antigens in detail

A new method to assess the status of immune responses to specific antigens in detail by analysis using the B cell receptor (BCR) repertoire has been developed by a research group, consisting of Assistant Professor Yohei Funakoshi, Associate Professor Kimikazu Yakushijin, Professor Hironobu Minami (Kobe University Graduate School of Medicine), Associate Professor Goh Ohji (Kobe University Hospital), and Researcher Takaji Matsutani (Repertoire Genesis Inc.).

18 Aug 2023

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Pharmaceutical News

Novavax's protein-based COVID vaccine induces broad functional immune response against XBB subvariants, data shows

FDA approves more drugs based on single trials and less public disclosure of results

Small molecule inhibitor of the NLRP3 inflammasome for treating autoinflammatory diseases

Stowers researchers reveal why certain anti-cancer drugs can cause unexpected side effects

Project NextGen awards over $1.4 billion to develop the future of COVID-19 vaccines and therapeutics

Aspirin underutilized for preventing heart attack, stroke

Researchers decipher the mode of action of new antibiotic

Aspirin adherence after heart attack linked to lower risk of recurrent heart attack, stroke, death

Study explores mechanism behind liraglutide-associated weight loss in obese individuals

Study finds no link between short-term immunosuppressant use and cancer

New DNA-based anticoagulant could treat heparin-induced thrombocytopenia

COVID-19 associated with increased risk of developing various autoimmune diseases and risk could be attenuated by vaccination

Common genetic variants reduce clopidogrel effectiveness in British South Asians

A hybrid approach to re-engineer a SARS-CoV-1 neutralizing antibody against SARS-CoV-2

The standard of care and recent advancements in the control of skin inflammation

Proxalutamide shows promise as potential COVID-19 treatment

A peek at Big Pharma’s playbook that leaves many Americans unable to afford their drugs

Phase I trial shows promise: Brain stimulation spurs upper-extremity recovery in stroke patients

New findings could develop effective vaccines or treatments for chikungunya fever

New method to assess the status of immune responses to specific antigens in detail

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