T Cell News and Research

Latest T Cell News and Research

Researchers develop adult lung organoids that represent all cell types

Since the COVID-19 pandemic reached the United States in early 2020, scientists have struggled to find laboratory models of SARS-CoV-2 infection, the respiratory virus that causes COVID-19. Animal models fell short; attempts to grow adult human lungs have historically failed because not all of the cell types survived.

31 Aug 2021

Research highlights the importance of meninges for brain development and pathology

A new study, led by researchers at the University of Gothenburg, have generated the first comprehensive transcriptional atlas of neonatal mouse meningeal leukocytes, under normal conditions and after perinatal brain injury.

31 Aug 2021

New research has implications for developing cancer therapies targeting mutant p53 protein

The tumor suppressor protein p53 is mutated in more than half of all human cancers. Several drugs that potentially can restore mutant p53 to its normal cancer-killing function are in clinical investigation.

31 Aug 2021

Coronavirus buildup in the lungs is likely behind high mortality rates

A buildup of coronavirus in the lungs is likely behind the steep mortality rates seen in the pandemic, a new study finds.

31 Aug 2021

The tale of mRNA vaccines: Turning calamity into opportunity

In a review paper published in the journal Nature Reviews, researchers from Carnegie Mellon University and the University of Pennsylvania have described the underlying technologies for mRNA vaccines and their future prospects with improved delivery systems and applications in diseases beyond the ongoing COVID-19 pandemic.

31 Aug 2021

New compounds offer a two-for-one punch to fight estrogen-sensitive breast cancer

A set of compounds developed by scientists at Scripps Research in Florida target estrogen-sensitive breast cancer cells in new ways, potentially creating better options for patients with treatment-resistant cancers.

31 Aug 2021

Severe COVID-19 negatively impacts kidney function in kidney transplant recipients

During her medical school career, third-year student Skylar Nahi has taken advantage of the mentorship and research opportunities available to Feinberg students.

31 Aug 2021

Durability of cellular immune memory to SARS-CoV-2 after mRNA vaccination

A recent study, available on the bioRxiv* preprint server, investigated the durability of cellular immune memory after mRNA vaccination against SARS-CoV-2 and whether booster jabs affect the durability of different immune response components. The study included testing for antibodies and cellular immune responses in covid patients and recovered individuals.

31 Aug 2021

Study identifies actionable genes and candidate drugs in biliary tract cancer using a knowledgebase

Oncotarget published "Actionability evaluation of biliary tract cancer by genome transcriptome analysis and Asian cancer knowledgebase" which reported that it is necessary to investigate actionable genes and candidate drugs using a sophisticated knowledgebase and characterize BTCs immunologically for evaluating the actionability of molecular and immune therapies.

31 Aug 2021

Scientists identify potential biomarkers to predict COVID-19 outcomes

A team of scientists from the United States has recently examined the trajectory of early immune biomarkers in response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. They have identified specific plasma proteins that can accurately predict the clinical and virological outcomes in SARS-CoV-2 infected patients. The study is currently available on the medRxiv* preprint server.

31 Aug 2021

DNMT2/TRDMT1 gene knockout may potentiate adverse effects related to drug-induced senescence

Aging-US published "The lack of functional DNMT2/TRDMT1 gene modulates cancer cell responses during drug-induced senescence" which reported that cellular senescence may be a side effect of chemotherapy and other anti-cancer treatments that may promote inflammation and paracrine secondary senescence in healthy tissues.

31 Aug 2021

Role of glycans on the SARS-CoV-2 spike protein in human receptor interaction

A team of investigators, led by Dr. Benjamin F. Mann, from Merck, USA have published a new study on the preprint server bioRxiv*. They have used a biochemical approach to control the glycosylation profile of the S protein receptor-binding domain (RBD) and to analyze the effect of different glycosylation patterns on receptor binding.

30 Aug 2021

COVID-19 vaccine elicits antibody responses in nearly 9 out of 10 people taking immunosuppressants

COVID-19 vaccination elicited antibody responses in nearly nine out of 10 people with weakened immune systems, although their responses were only about one-third as strong as those mounted by healthy people, according to a study by researchers at Washington University School of Medicine in St. Louis.

30 Aug 2021

How early interferon curbs SARS-CoV-2 infection

A new study available in the Journal of Experimental Medicine focuses on the importance of interferon in SARS-CoV-2 infection.

30 Aug 2021

Will mRNA vaccine boosters be required for SARS-CoV-2 variants?

A new study shows that the highly effective mRNA Moderna vaccine designed against the original SARS-CoV-2 strain may lose some efficacy as new variants arise.

30 Aug 2021

UH associate professor receives $2.5 million to explore how arterial hardening starts within cells

In diseases such as hypertension, aging, atherosclerosis, diabetes and chronic kidney disease, arterial calcification and stiffening of the elastic layer of the arterial wall are almost always present.

30 Aug 2021

Sustained and effective response to Janssen COVID-19 vaccine Is enhanced by delayed booster

A new study adds to the data on the optimum interval between the first and second doses of the adenovirus vectored COVID-19 vaccine.

30 Aug 2021

Could genetic variants in host cell receptors (ACE2) explain COVID-19 susceptibility among certain ethnic groups?

Led by Ioannis Karakikes of Stanford University, a new study suggests some hospitalized patients with COVID-19 contain ACE2 genetic variants that increase ACE2 expression. Some variants that altered ACE2 protein expression and binding affinity were more prevalent in people with European backgrounds.

30 Aug 2021

Study reveals how SARS-CoV-2 variants of concern modulate receptor and antibody binding

In a trailblazing engineering effort, Canadian and US researchers indicate that the emergence of novel variants of SARS-CoV-2 stems from the mutations of spike glycoprotein that confer either increased affinity for the host cell receptor or increased antibody evasion.

30 Aug 2021

New study analyzes altered gene expression in severe COVID-19

In a paper recently uploaded to the bioRxiv* preprint server, the genetic link between COVID-19 severity and gene expression is investigated, hoping to allow early identification of otherwise healthy individuals that will likely require hospitalization if infected.

30 Aug 2021

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T Cell News and Research

Latest T Cell News and Research

Researchers develop adult lung organoids that represent all cell types

Research highlights the importance of meninges for brain development and pathology

New research has implications for developing cancer therapies targeting mutant p53 protein

Coronavirus buildup in the lungs is likely behind high mortality rates

The tale of mRNA vaccines: Turning calamity into opportunity

New compounds offer a two-for-one punch to fight estrogen-sensitive breast cancer

Severe COVID-19 negatively impacts kidney function in kidney transplant recipients

Durability of cellular immune memory to SARS-CoV-2 after mRNA vaccination

Study identifies actionable genes and candidate drugs in biliary tract cancer using a knowledgebase

Scientists identify potential biomarkers to predict COVID-19 outcomes

DNMT2/TRDMT1 gene knockout may potentiate adverse effects related to drug-induced senescence

Role of glycans on the SARS-CoV-2 spike protein in human receptor interaction

COVID-19 vaccine elicits antibody responses in nearly 9 out of 10 people taking immunosuppressants

How early interferon curbs SARS-CoV-2 infection

Will mRNA vaccine boosters be required for SARS-CoV-2 variants?

UH associate professor receives $2.5 million to explore how arterial hardening starts within cells

Sustained and effective response to Janssen COVID-19 vaccine Is enhanced by delayed booster

Could genetic variants in host cell receptors (ACE2) explain COVID-19 susceptibility among certain ethnic groups?

Study reveals how SARS-CoV-2 variants of concern modulate receptor and antibody binding

New study analyzes altered gene expression in severe COVID-19

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T Cell News and Research

Latest T Cell News and Research

Immunology eBook

CellVoyant's AI-Powered Vision for the Future of Cell Therapy

Scalable, Smart, and Accessible: The Future of Lab Automation

Healthy Beginnings, Hopeful Futures: A Conversation with WHO’s Dr. Allotey

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