T Cell News and Research

Latest T Cell News and Research

New mouse line reveals the state of protein balance in the mammalian brain for the first time

Proteins are the "tools" of our cells – they are essential to all vital tasks. However, they are only able to do their jobs if they fold correctly and adopt their respective, very specific 3D structure.

20 Aug 2021

Study illuminates genetic understanding of aggressive childhood leukemias

New research published today in JAMA Oncology reports how two separate DNA changes appear to predict aggressive childhood leukemias when they occur in combination.

20 Aug 2021

Study: PirB inhibits the self-renewal and differentiation capacities of neural stem cells

Aging-US published "PirB functions as an intrinsic suppressor in hippocampal neural stem cells" which reported that neural stem cells play pivotal roles during prenatal development and throughout life.

20 Aug 2021

Researchers use ancient mammalian proteins to develop mRNA delivery system

Using a family of mammalian proteins adopted from ancient retroviral legacy genes, researchers have developed a novel system for programmable intracellular mRNA delivery.

20 Aug 2021

Research could enable clinicians to produce patient-matched cells for treating muscle-related diseases

Investigators who previously developed a recipe for turning skin cells into primitive muscle-like cells that can be maintained indefinitely in the lab without losing the potential to become mature muscle have now uncovered how this recipe works and what molecular changes it triggers within cells.

19 Aug 2021

Prior treatment may impact efficacy of ACT-TIL in patients with metastatic melanoma

Patients with metastatic melanoma that had relapsed on anti-PD-1 therapies or BRAF/MEK inhibitors did not respond as well to an investigational therapy that involves the adoptive cell transfer of tumor-infiltrating lymphocytes (ACT-TIL) as patients naïve to these treatments.

19 Aug 2021

HMGA1 plays role in gastric cancer cell proliferation and metastasis

Aging-US published "HMGA1 promotes gastric cancer growth and metastasis by transactivating SUZ12 and CCDC43 expression" which reported that HMGA1 is overexpressed in GC cells and the high expression of HMGA1 was correlated with worse survival in GC patients using a bioinformatics assay.

19 Aug 2021

Researchers discover glycan 'gates' that open to allow SARS-CoV-2 entry

Since the early days of the COVID pandemic, scientists have aggressively pursued the secrets of the mechanisms that allow severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to enter and infect healthy human cells.

19 Aug 2021

Scientists develop a new way to deliver molecular therapies to cells

Researchers from MIT, the McGovern Institute for Brain Research at MIT, the Howard Hughes Medical Institute, and the Broad Institute of MIT and Harvard have developed a new way to deliver molecular therapies to cells.

19 Aug 2021

Study identifies the cause and treatment for rare rheumatoid-like autoinflammatory condition

The absence of a protein that activates the body's antiviral defenses can cause a rare rheumatoid-like autoinflammatory condition that is treatable with an FDA-approved class of drugs known as TNF (tumor necrosis factor) inhibitors, a global research team led by Mount Sinai has found.

19 Aug 2021

Existing drugs block or reduce SARS-CoV2 infection in cells

Since the beginning of the pandemic, researchers worldwide have been looking for ways to treat COVID-19. And while the COVID-19 vaccines represent the best measure to prevent the disease, therapies for those who do get infected remain in short supply.

19 Aug 2021

MD Anderson receives nearly $13 million from CPRIT to support research efforts

The University of Texas MD Anderson Cancer Center has been awarded $12.75 million from the Cancer Prevention and Research Institute of Texas to support basic, clinical, translational and prevention research efforts, including $3 million for a new project to build clinical trial network infrastructure across Texas.

19 Aug 2021

Researchers identify antibodies that could protect against alphaviruses

Alphaviruses - mosquito-borne viruses that can trigger brain infections and arthritis -; may have met their match.

19 Aug 2021

SARS-CoV-2 antibodies found to neutralize bat coronavirus (RaTG13) in new study

A striking new study examines how far antibodies elicited by vaccines against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), or by natural infection, can neutralize the closely related bat coronavirus (CoV) RaTG13.

19 Aug 2021

How does the SARS-CoV-2 Delta variant’s spike drive membrane fusion and immunity evasion?

A fascinating and timely new study shows how the Delta variant of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) achieved higher transmissibility and resistance to neutralization.

19 Aug 2021

Durable highly protective T cell response to AAV-spike vaccine against COVID-19 pneumonia in mice

New research, available as a preprint on the bioRxiv* server, has focused on the role played by T cell immunity, particularly CD8+ cytotoxic T cells, on preventing lethal infection with SARS-CoV-2 in mice infused with peptide-loaded antigen-presenting dendritic cells (DCs).

19 Aug 2021

Early clinical trial data in for whole virus COVID-19 vaccine candidate

In a study uploaded to the preprint server medRxiv*, the efficacy of a whole virion Coronavirus vaccine was determined by giving the vaccine to healthy adult volunteers, which generated a robust immune response with evidence of T-cell activation.

19 Aug 2021

Scientists identify a potent neutralizing nanobody against SARS-CoV-1

In a recently published article in the journal Virologica Sinica, scientists have described the development and validation of a potent nanobody that targets the receptor-binding domain (RBD) of severe acute respiratory syndrome coronavirus (SARS-CoV). The nanobody efficiently and specifically blocks the interaction between RBD and angiotensin-converting enzyme 2 (ACE2) and neutralizes the virus.

19 Aug 2021

Arteriolar niche used by breast cancer cells to prepare for metastasis

More than 43,000 American women will die from breast cancer this year. Most of those deaths will occur after the cancer has spread to other organs, a process called metastasis. This involves at least five major steps.

19 Aug 2021

White-tailed deer are highly susceptible to SARS-CoV-2 infection

The SARS-CoV-2 virus has been shown to infect a wide range of animals naturally and experimentally, and prior studies indicate deer are susceptible to infection. White-tailed deer (Odocoileus virginianus) fawns have been found to be susceptible to SARS-CoV-2.

19 Aug 2021