HeartWare International presents clinical trial data of Ventricular Assist System at ISHLT annual meeting

Apr 24 2010

HeartWare International, Inc. (Nasdaq: HTWR; ASX: HIN), a leading innovator of less invasive, miniaturized circulatory support technologies revolutionizing the treatment of advanced heart failure, today announced that data from its international clinical trial and commercial experience of the HeartWare® Ventricular Assist System showed a survival rate of 90 percent at six months and an actuarial survival rate of 86 percent at 12 months post implant.  The results were presented by Martin Strueber, M.D., cardiothoracic surgeon at Hannover Medical School, at the annual meeting of the International Society for Heart and Lung Transplantation (ISHLT) held in Chicago this week.  

The data presented at ISHLT includes all 50 patients enrolled in the Company's international clinical trial, as well as the first 50 commercial patients. Survival rates were identical between the commercial and clinical groups, with 45 of 50 patients (90 percent) alive at the 180-day mark, and the reported adverse events were similar in each group.

Enrollment in the international clinical trial was completed in December 2008, while the first 50 commercial implants occurred between January and September in 2009.  In all, 10 centers (five clinical trial sites, as well as five commercial sites) in five countries contributed to this data set.  The average age of the 100-patient pool was 50.5 years old, with the youngest being 16 years old.

Dr. Strueber, a principal investigator in the original international trial, noted that "14 percent of the implants were conducted by thoracotomy, with 86 percent through a typical sternotomy, thereby reinforcing the versatility of the HeartWare® HVAD® pump and potential for less invasive procedures in the future."

Duration of support averaged 444 days in the clinical trial population, compared with 203 days in the more recently implanted commercial group.  The longest duration of support was 1,108 days.  Seven patients were transplanted within 180 days in the clinical trial group, compared to four in the commercial group.  

HeartWare CEO and President Doug Godshall noted, "In each of the past three years, we have met and presented at ISHLT, and thanks to longer followup, we have been able to demonstrate more evidence of effectiveness of our HeartWare Ventricular Assist System.  We are delighted that in a sicker cohort across a broader spectrum of sites our strong survival data was maintained in the commercial setting."

In the United States, HeartWare is conducting the ADVANCE clinical trial in which 140 patients at 30 U.S. clinical sites received HeartWare HVAD pumps, making it the largest bridge-to-transplant pivotal trial to date.  Enrollment in ADVANCE was completed in February 2010, and subsequent to the expected conclusion of patient followup in August 2010, HeartWare anticipates filing a Premarket Approval Application (PMA) by year end.

In a separate presentation at ISHLT today, Mark Slaughter, M.D., of University of Louisville presented: "Design and Feasibility Testing of a Miniaturized Transapical Mechanical Circulatory Support Device: MVAD."  In his presentation, Dr. Slaughter reported that HeartWare's novel, miniaturized wearless wide blade impeller system (MVAD) provided support for a 30-day period without complications.  In 12 bovine studies, all MVAD pumps were successfully implanted via left thoracotomy, without sternotomy and with no cardiopulmonary bypass.  The MVAD demonstrated good hemodynamic performance and hemocompatability in this test model.