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Prediction of antibody responses in recovered COVID-19 patients remains unclear

It is crucial to gain a better understanding of how an antibody response is developed against SARS-CoV-2, and how long it lasts. This will determine the antibody titers and duration that protect against reinfection by the virus. A new preprint on the medRxiv* server shows this to be still a distant goal.

22 Mar 2021

Could nanoparticle vaccines offer broad protection against sarbecoviruses?

To understand the ability of SARS-CoV-2 vaccine-elicited antibodies to neutralize and protect against emerging variants (that are pathogenic) and other sarbecoviruses, a large team of researchers studied immunity by receptor-binding domain nanoparticle vaccines. They showed that a clinical-stage multivalent SARS-CoV-2 receptor-binding domain nanoparticle vaccine (SARS-CoV-2 RBD-NP) protected mice from the SARS-CoV-2-induced disease.

22 Mar 2021

Circular RNA vaccine shows neutralizing activity against B.1.351 variant

New preclinical research led by Wensheng Wei from Peking University in China has proposed the development of a circular RNA vaccine. Their findings showed the circular RNA vaccine creates neutralizing antibodies and strong T-cell responses against the receptor-binding domain of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein.

21 Mar 2021

ChAdOx1 nCoV-19 offers less protection against South African SARS-CoV-2 variant

The results of a double-blind, randomized, multisite placebo-controlled trial that was conducted in South Africa show that Oxford’s ChAdOx1 nCoV-19 (AZD1222) vaccine has no efficacy against the B.1.351 variant in preventing mild-to-moderate coronavirus disease 2019 (COVID-19), and shows reduced neutralization properties of developed antibodies. The findings are published in the New England Journal of Medicine.

21 Mar 2021

DNA spike-ins increase reliability of amplicon-based sequencing of SARS-CoV-2 genomes

In the interests of cost-effectiveness and rapidity, amplicon-based sequencing of the viral genome has been used to provide a sensitive means of genomic surveillance. A new preprint, which was released on the bioRxiv* server, shows how this can be tweaked to make it a reliable source of genomic data by reducing the known potential for contamination.

19 Mar 2021

Diagnostic test helps identify the virulent forms of swine bacterial pathogens

A team led by researchers in Penn State's College of Agricultural Sciences has developed a diagnostic test that can identify virulent forms of the swine bacterial pathogen Streptococcus equi subspecies zooepidemicus -- often referred to as "Strep zoo" -- which can cause severe illness and death in pigs, other animals and rarely people.

19 Mar 2021

Study shows how ACE2 mutations influence SARS-CoV-2 spike binding in humans and animals

Researchers at the University of Wisconsin–Madison aimed to better understand how SARS-CoV-2 interacts with various mammalian angiotensin-converting enzyme 2 (ACE2) receptors. This way, they can identify the factors that influence intra- and cross-species virus transmission.

18 Mar 2021

The role of S-acylation in the enhancement of SARS-CoV-2 infectivity

A new study published on the bioRxiv server focuses on the role of S-acylation in the SARS-CoV-2 infection cycle. It has also characterized Spike acylation and has also identified other acylated viral proteins and host enzymes involved in the process of infection. Further, it has also revealed the importance of acylation in viral biogenesis and infection.

18 Mar 2021

Scientists identify address codes in odorant receptor proteins

A team of scientists led by Dietmar Krautwurst from the Leibniz Institute for Food Systems Biology at the Technical University of Munich has now identified address codes in odorant receptor proteins for the first time.

17 Mar 2021

Researchers develop rapid method for identifying antibody-resistant SARS-CoV-2 mutants

Researchers in the United States have described a novel rapid method for identifying antibody-resistant mutants in SARS-CoV-2.

17 Mar 2021

Two mouthwashes disrupt COVID-19 virus under laboratory conditions

Researchers at Rutgers School of Dental Medicine have found evidence that two types of mouthwash disrupt the COVID-19 virus under laboratory conditions, preventing it from replicating in a human cell.

17 Mar 2021

Quantum dot-based affinity biosensors in microfluidic systems offer an alternative SARS-CoV-2 diagnostics platform

In a new study published in Emergent Materials, researchers show how microfluidic systems integrated with quantum dot-based affinity biosensors can serve as a valuable platform to rapidly and accurately diagnose SARS-CoV-2 infection.

17 Mar 2021

INTEGRA’s electronic pipettes eliminate user fatigue and improve pipetting productivity

CDI Labs – a biotechnology company based in Puerto Rico – is using INTEGRA’s VIAFLO and VOYAGER electronic pipettes to streamline workflows and improve accuracy for the development of next generation proteomics products.

From INTEGRA Biosciences 17 Mar 2021

Researchers develop innovative profiling methods for SARS-CoV-2 infection

A team of researchers from various institutions in the USA used RNA-sequencing data and other methods to profile unique genes and other characteristics associated with SARS-CoV-2 in New York City (NYC).

17 Mar 2021

Salivary IgG to SARS-CoV-2 after mild COVID-19

A team of researchers based in Stockholm, Sweden, has demonstrated that individuals exposed to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have antibodies for the disease up to nine months after acquiring the disease, even if they displayed only mild symptoms.

16 Mar 2021

Novel protein construct prevents lethal COVID-19 in mice

Researchers in the United States have developed a novel protein that prevented lethal disease among mice infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

16 Mar 2021

Saliva-based testing as a method for monitoring population immunity to SARS-CoV-2 infection

Researchers in the United States have shown that saliva-based sampling could serve as an accurate and non-invasive alternative to blood sampling for monitoring people’s antibody responses following infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or vaccination against the virus.

16 Mar 2021

URI researchers develop new, saliva-based COVID-19 test

Researchers at the University of Rhode Island have developed a new COVID-19 test that will soon be put into use across its campuses as a screening and surveillance tool for the COVID-19 virus.

16 Mar 2021

Backtracking occurs within SARS-CoV-2 replication-transcription complex

Researchers continue to achieve a better understanding of SARS-CoV-2, the virus behind the ongoing COVID-19 pandemic. One such effort has been reported in a new preprint on the bioRxiv server, dealing with the phenomenon of backtracking.

16 Mar 2021

Study unveils SARS-CoV-2 persistence and contamination concentration on common surfaces

A recent environmental study from the United Kingdom, currently available on the bioRxiv preprint server, shows that certain common surfaces could represent an infectious risk if contaminated with high concentrations of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – albeit the level of viable viral particles is likely to be low.

15 Mar 2021

Assay News and Research

Prediction of antibody responses in recovered COVID-19 patients remains unclear

Could nanoparticle vaccines offer broad protection against sarbecoviruses?

Circular RNA vaccine shows neutralizing activity against B.1.351 variant

ChAdOx1 nCoV-19 offers less protection against South African SARS-CoV-2 variant

DNA spike-ins increase reliability of amplicon-based sequencing of SARS-CoV-2 genomes

Diagnostic test helps identify the virulent forms of swine bacterial pathogens

Study shows how ACE2 mutations influence SARS-CoV-2 spike binding in humans and animals

The role of S-acylation in the enhancement of SARS-CoV-2 infectivity

Scientists identify address codes in odorant receptor proteins

Researchers develop rapid method for identifying antibody-resistant SARS-CoV-2 mutants

Two mouthwashes disrupt COVID-19 virus under laboratory conditions

Quantum dot-based affinity biosensors in microfluidic systems offer an alternative SARS-CoV-2 diagnostics platform

INTEGRA’s electronic pipettes eliminate user fatigue and improve pipetting productivity

Researchers develop innovative profiling methods for SARS-CoV-2 infection

Salivary IgG to SARS-CoV-2 after mild COVID-19

Novel protein construct prevents lethal COVID-19 in mice

Saliva-based testing as a method for monitoring population immunity to SARS-CoV-2 infection

URI researchers develop new, saliva-based COVID-19 test

Backtracking occurs within SARS-CoV-2 replication-transcription complex

Study unveils SARS-CoV-2 persistence and contamination concentration on common surfaces

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