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South African and Brazilian SARS-CoV-2 variants can evade antibodies from therapies, vaccines, and infection

Researchers at the Infection Biology Unit, German Primate Center, and the Georg-August-University Göttingen in Germany have found that the B.1.351 and P.1 SARS-CoV-2 variants have the potential to evade therapeutic antibodies or antibodies induced by natural infection or vaccination.

7 Apr 2021

UNION therapeutics’ COVID-19 candidates show promising results in phase 1 study

UNION therapeutics A/S (UNION) announced today that the results of a phase 1 study of inhaled and intranasal niclosamide (UNI911) have been published by The Lancet Regional Health – Europe.

7 Apr 2021

Researchers use South Korea Data to create new framework for COVID-19-vulnerable locales

Though the U.S. and South Korea recorded their first official COVID-19 case on the same day, January 20, 2020, there were notable differences in how each country would ultimately address what has become the world's most severe pandemic since 1918.

7 Apr 2021

Antifungal and antidepressant drugs can effectively inhibit COVID-19 virus

New research published in the British Journal of Pharmacology indicates that two currently available medications--an antifungal drug and an antidepressant--can effectively inhibit the virus that causes COVID-19 in laboratory cells.

7 Apr 2021

Expert calls for swift action to avoid chronic health conditions caused by COVID-19

A tsunami of chronic health conditions as a result of the SARS-CoV-2 pandemic, especially cardiometabolic disease, may produce an enormous wave of death and disability that demands immediate, comprehensive strategies.

7 Apr 2021

70% of SARS-CoV-2 infected in Wuhan still have IgG antibodies

The coronavirus disease (COVID-19) first emerged in late December 2019 in Wuhan, China. Though it has been more than one year since the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was reported, it is still unclear how long the antibodies persist in those who have recovered.

7 Apr 2021

COVID-19 infection linked to neurological and mental health conditions

One in three COVID-19 survivors received a neurological or psychiatric diagnosis within six months of infection with the SARS-CoV-2 virus, an observational study of more than 230,000 patient health records published in The Lancet Psychiatry journal estimates. The study looked at 14 neurological and mental health disorders.

7 Apr 2021

Study: Multidrug-resistant fungus that infests hospitals may have emerged from the wild

C. auris, a drug-resistant fungus that infests hospitals, may have emerged from the wild, says study. Researchers confirmed the presence in the wild of Candida auris, a multidrug-resistant fungus commonly found infesting hospitals.

7 Apr 2021

Natural selection and adaptation of SARS-CoV-2 in mammals

Researchers of the Hubei University of Medicine, China, have analyzed several mutations in different variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from mammal species that suggest natural selection and host adaptation are occurring in the virus.

6 Apr 2021

FDA authorizes use of Symbiotica COVID-19 Self-Collected Antibody Test System

The U.S. Food and Drug Administration today announced it has issued an emergency use authorization for the Symbiotica COVID-19 Self-Collected Antibody Test System, the first antibody test authorized for use with home collected dried blood spot samples.

6 Apr 2021

Researchers identify a novel SARS-CoV-2 variant (A.VOI.V2) in southern Africa

Scientists recently explored the transmission dynamics of currently circulating variants of SARS-CoV-2 in a southern African country. By analyzing the genomic sequences of these variants, they have identified a novel SARS-CoV-2 variant with multiple spike mutations. They have temporarily designated the variant A.VOI.V2.

6 Apr 2021

Can limiting the priming dose of a SARS-CoV-2 vaccine improve immunity?

Researchers from Northwestern University and the University of Rochester in the U.S. addressed this question in their study. The researchers also explored whether the vaccines administered across the world could confer sterilizing immunity while preventing severe disease and death.

6 Apr 2021

Is non-severe SARS-CoV-2 infection characterized by early T cell proliferation?

To date, little evidence has been documented regarding the immune responses after the onset of the symptoms or virus detection. Further, no cross-sectional studies have been conducted that define the time of infection. Thereby, no report is available that explains the relationship between the earliest immune responses to COVID-19 and temporal kinetics. New research deals with this research gap using blood transcriptomics, multiparameter flow cytometry, and T cell receptor (TCR) sequencing methods.

6 Apr 2021

Study suggests T-cells don't determine survival in severe COVID-19

In the study, which appeared on the pre-print server medRxiv, the team found that when the monkeys were reinfected, the T cell-depleted animals showed anamnestic immune responses, the enhanced reaction of the body's immune system to an antigen that is related to an antigen previously encountered.

6 Apr 2021

Research shows efficacy of early warning signals for disease emergence amid COVID-19

The study, published on the pre-print server medRxiv, shows that early warning signals (EWS) provide expected trends, predicting future epidemics and disease emergence.

6 Apr 2021

CAL20.C SARS-CoV-2 variant skyrocketing in California evades host immune response

In a study published on the bioRxiv* preprint server, researchers report the effect of neutralizing antibodies from recovered patients or mRNA vaccinated individuals on neutralizing this variant.

6 Apr 2021

Researchers take key step toward new drugs and vaccines to combat COVID-19

Researchers in the Oregon State University College of Science have taken a key step toward new drugs and vaccines for combating COVID-19 with a deep dive into one protein's interactions with SARS-CoV-2 genetic material.

6 Apr 2021

Novel hydrogel-based vaccine formulation shows high efficacy against SARS-CoV-2

A fascinating new preprint research paper posted to the bioRxiv* server discusses impressively high neutralizing responses elicited with a single dose of a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine formulation, which could help turn the tide of the current pandemic if validated.

6 Apr 2021

Research explores sex differences in placental defenses against SARS-CoV-2 infection

A plethora of earlier studies has reported on the differences between the sexes in susceptibility to the currently circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), as well as its severity. A new preprint research paper posted to the bioRxiv* server extends this to the placenta in pregnancy.

6 Apr 2021

South Africa SARS-CoV-2 variant B.1.351 easily escapes Sputnik vaccine

A new preprint research paper posted to the medRxiv* server reports on vaccine resistance data that pushes the end of the pandemic further away.

6 Apr 2021

SARS News and Research

South African and Brazilian SARS-CoV-2 variants can evade antibodies from therapies, vaccines, and infection

UNION therapeutics’ COVID-19 candidates show promising results in phase 1 study

Researchers use South Korea Data to create new framework for COVID-19-vulnerable locales

Antifungal and antidepressant drugs can effectively inhibit COVID-19 virus

Expert calls for swift action to avoid chronic health conditions caused by COVID-19

70% of SARS-CoV-2 infected in Wuhan still have IgG antibodies

COVID-19 infection linked to neurological and mental health conditions

Study: Multidrug-resistant fungus that infests hospitals may have emerged from the wild

Natural selection and adaptation of SARS-CoV-2 in mammals

FDA authorizes use of Symbiotica COVID-19 Self-Collected Antibody Test System

Researchers identify a novel SARS-CoV-2 variant (A.VOI.V2) in southern Africa

Can limiting the priming dose of a SARS-CoV-2 vaccine improve immunity?

Is non-severe SARS-CoV-2 infection characterized by early T cell proliferation?

Study suggests T-cells don't determine survival in severe COVID-19

Research shows efficacy of early warning signals for disease emergence amid COVID-19

CAL20.C SARS-CoV-2 variant skyrocketing in California evades host immune response

Researchers take key step toward new drugs and vaccines to combat COVID-19

Novel hydrogel-based vaccine formulation shows high efficacy against SARS-CoV-2

Research explores sex differences in placental defenses against SARS-CoV-2 infection

South Africa SARS-CoV-2 variant B.1.351 easily escapes Sputnik vaccine

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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