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Study shows mRNA booster dose eliminates immune escape observed with SARS-CoV-2 Omicron

Researchers examined total and neutralizing antibodies to the spike protein of SARS-CoV-2, and neutralizing antibodies against Washington-1 (WA-1) and variants of concern (VOC) including Beta, Delta, and Omicron in a longitudinal cohort.

31 Jan 2022

Preliminary study assesses durability of NAb titers against Omicron after mRNA-1273 booster

Researchers from Moderna, the developers of one key vaccine, have been investigating its ability to protect against the Omicron variant.

31 Jan 2022

Vaccine-induced immunological memory is similar for Omicron and Delta SARS-CoV-2 variants

A new study by Norwegian researchers suggests that vaccine-induced immunological memory and the activation of recall responses in the body yields similar coverage for Omicron and Delta variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The paper is currently available on the medRxiv* preprint server while it undergoes peer review.

31 Jan 2022

Children and adolescents respond as well or better than adults to mRNA-1273 COVID vaccination

A recent study assesses the neutralization efficacy of the mRNA-1273 vaccine against the SARS-CoV-2 Omicron variant in children, adolescents, and adults.

30 Jan 2022

Immunity based upon “mild" Omicron infection is weak for Omicron reinfection

Researchers evaluate antibody responses in vaccinated individuals who subsequently developed Delta and Omicron SARS-CoV-2 breakthrough infections.

30 Jan 2022

Scientists evaluate zoonotic potential of NeoCoV, a coronavirus related to MERS-CoV

Researchers identify ACE2 as the functional receptor of the two close relatives of MERS-CoV, NeoCoV and PDF-2180-CoV, in bats.

30 Jan 2022

Imaging microscopy shows killer T-cells targeting SARS-CoV-2 spike protein

Researchers demonstrate how cytotoxic T-lymphocytes (CTLs) with specificity for SARS-CoV-2 eliminate multiple infected targets.

30 Jan 2022

Adults and children have similar neutralizing antibody responses to SARS-CoV-2 infection

Researchers describe the kinetics of SARS-CoV-2-specific serum antibodies in convalescent children over six months following infection.

30 Jan 2022

New app and lab kit transform a smartphone into COVID-19 / flu detection system

In a potential game changer for COVID-19 pandemic control efforts, a new cell phone app and lab kit have transformed a smartphone into a COVID-19 / flu detection system.

29 Jan 2022

Evidence on intra-host recombination of SARS-CoV-2 during superinfection by Alpha and Epsilon variants in USA

A new study captured an instance of SARS-CoV-2 superinfection in an individual, simultaneously infected by two SARS-CoV-2 variants, Alpha and Epsilon during the second COVID-19 wave in New York City in early 2021.

28 Jan 2022

Reduced neutralization against Omicron variant in fully immunized adolescents with BNT162b2 vaccine

Researchers compare the humoral immune response in adolescents and adults after being completely immunized with the Pfizer BNT162b2 vaccine.

28 Jan 2022

Impact of DNA clearance on mortality in patients with severe COVID-19 infections

In a new study, researchers conducted activity-based proteomic profiling of patients who had severe SARS-CoV-2 infections to understand the impact of DNA clearance on mortality.

28 Jan 2022

Exploring receptor-blocking conserved non-neutralizing antibodies for SARS-CoV-2 therapy

In a new study, researchers hypothesized and developed broad-spectrum SARS-CoV-2 inhibitors, ReconnAbs, by modifying the existing non-neutralizing antibodies targeted towards the highly conserved epitopes of the SARS-CoV-2 spike (S) protein combined with a receptor-blocking component.

28 Jan 2022

Intranasal interferon-λ treatment protects mice against SARS-CoV-2 Beta and Omicron variants

Researchers investigate the possible efficacy of IFN-λ in the context of SARS-CoV-2 infection in mice.

28 Jan 2022

Low Dead Volume Reservoir Trays

Precision manufactured to SBS / SLAS dimensions - Porvair Sciences range of reservoir trays are designed for simple integration with any robotic liquid handling system.

From Porvair Sciences Limited 28 Jan 2022

Early-stage alveolar epithelial cell necrosis linked to COVID-19-induced acute respiratory distress syndrome

A new study analyzed whether alveolar epithelial cell necrosis at an early stage SARS-CoV-2 infection and subsequent releases of damage-associated molecular patterns could aggravate COVID-19-associated acute respiratory distress syndrome.

27 Jan 2022

SARS-CoV-2 mutations and their impact on spike protein-specific T lymphocytes

New research assesses the impact of mutations in SARS-CoV-2 variants of concern (VOCs) on the T lymphocytes, specifically to the spike (S) protein of SARS-CoV-2.

27 Jan 2022

Study suggests enhanced phosphorylation and increased abundance of SARS-CoV-2 nucleocapsid protein provide selective advantage

Researchers have been investigating the phosphorylation of the nucleocapsid protein.

27 Jan 2022

Recipients of inactivated COVID-19 vaccine (CoronaVac) can be successfully boosted with different vaccines

In the recently published study in The Lancet, first-authored by Dr. Sue Ann Costa Clemens from the University of Oxford in the United Kingdom and the University of Siena in Italy, a comprehensive analysis has been pursued on the immunogenicity and safety of both homologous and heterologous boosting after receiving the inactivated vaccine CoronaVac.

26 Jan 2022

T-cell apoptosis linked to poor prognosis among COVID-19 patients

Researchers assess the probability of T-cell apoptosis in patients with severe COVID-19 who were admitted to the hospital.

26 Jan 2022

Assay News and Research

Study shows mRNA booster dose eliminates immune escape observed with SARS-CoV-2 Omicron

Preliminary study assesses durability of NAb titers against Omicron after mRNA-1273 booster

Vaccine-induced immunological memory is similar for Omicron and Delta SARS-CoV-2 variants

Children and adolescents respond as well or better than adults to mRNA-1273 COVID vaccination

Immunity based upon “mild" Omicron infection is weak for Omicron reinfection

Scientists evaluate zoonotic potential of NeoCoV, a coronavirus related to MERS-CoV

Imaging microscopy shows killer T-cells targeting SARS-CoV-2 spike protein

Adults and children have similar neutralizing antibody responses to SARS-CoV-2 infection

New app and lab kit transform a smartphone into COVID-19 / flu detection system

Evidence on intra-host recombination of SARS-CoV-2 during superinfection by Alpha and Epsilon variants in USA

Reduced neutralization against Omicron variant in fully immunized adolescents with BNT162b2 vaccine

Impact of DNA clearance on mortality in patients with severe COVID-19 infections

Exploring receptor-blocking conserved non-neutralizing antibodies for SARS-CoV-2 therapy

Intranasal interferon-λ treatment protects mice against SARS-CoV-2 Beta and Omicron variants

Low Dead Volume Reservoir Trays

Early-stage alveolar epithelial cell necrosis linked to COVID-19-induced acute respiratory distress syndrome

SARS-CoV-2 mutations and their impact on spike protein-specific T lymphocytes

Study suggests enhanced phosphorylation and increased abundance of SARS-CoV-2 nucleocapsid protein provide selective advantage

Recipients of inactivated COVID-19 vaccine (CoronaVac) can be successfully boosted with different vaccines

T-cell apoptosis linked to poor prognosis among COVID-19 patients

eBook: Using iPSCs models for human disease research and drug discovery eBook

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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