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SARS-CoV-2 spike engagement of ACE2 shown to prime S2′ site cleavage and fusion initiation

In a new study, researchers used a cell-cell fusion assay to extract potentially cleaved spike protein products from syncytia in order to explore the functional and biochemical characteristics of spike (S) protein when it engages its receptor ACE2 in living cells.

10 Jan 2022

Engineered small extracellular vesicles for the neutralization of SARS-CoV-2

Characterizing these engineered sEVs, the researchers demonstrated that the soluble angiotensin-converting enzyme 2 (sACE-2) loaded sEV successfully binds and thus inhibits the entry of wild-type SARS-CoV-2 as well as its variants, protecting against SARS-CoV-2 infection. They also demonstrated the therapeutic efficacy of these engineered sEVs in vivo.

9 Jan 2022

Bolstering current therapeutic antibody treatments to help fight Omicron infections

Researchers test the neutralizing action of a panel of eight therapeutic monoclonal antibodies against the SARS-CoV-2 Omicron (B.1.1.529) variant.

9 Jan 2022

SARS-CoV-2 Omicron variant uses endosomal entry pathway and grows in upper respiratory tract cells

Researchers demonstrate that the SARS-CoV-2 Omicron variant grows rapidly in human primary nasal epithelial cultures.

9 Jan 2022

SARS‑CoV‑2 Omicron variant escapes monoclonal antibodies

Researchers determine the neutralizing activity of four mAbs against ten strains of SARS-CoV-2.

9 Jan 2022

Lab engineered human A549 lung cell model conducive for investigating SARS-CoV-2 antivirals

Researchers developed a human A549 lung epithelial cell-based model to probe SARS-CoV-2 replication.

9 Jan 2022

Dual-receptors help widespread dissemination of SARS-CoV-2

Researchers demonstrate the role of integrins in the establishment of the SARS-CoV-2 infection.

9 Jan 2022

Booster mRNA vaccination effective in reviving anti-SARS-CoV-2 antibody titers among the elderly

A new study found that a booster dose vaccination against COVID-19 was successful in taking binding. and neutralizing antibodies to levels higher than those observed after the initial double-dose regimen.

7 Jan 2022

Vaccine breakthrough COVID-19 infections found to be less likely transmitted

A new study displays that vaccine breakthrough COVID-19 infections are far less likely to transmit from the index patient to contacts than infections in partially or unvaccinated individuals.

7 Jan 2022

Reinfection with SARS-CoV-2 in children

These findings bear out earlier reports that COVID-19 is less frequent and severe in children than adults.

7 Jan 2022

Integrating Microplate Evaporators with Liquid Handling Robots

The Ultravap® Mistral family of microplate evaporators from Porvair Sciences are used in labs worldwide to remove the traditional laboratory ‘bottleneck’ of solvent evaporation from 12- to 384-well microplates and vials up to 15cm tall.

From Porvair Sciences Limited 7 Jan 2022

Broad cross-neutralization antibodies found to be effective against SARS-CoV-2 Omicron variant

A new study aimed to explore whether there is a way to induce the production of potent neutralizing antibodies capable of neutralizing all SARS-CoV-2 variants - including Omicron.

7 Jan 2022

Additional SARS-CoV-2 vaccine doses elicit robust seroresponse among patients receiving maintenance dialysis

Researchers thus recently published a report wherein they examined the seroresponse to an additional dose of vaccine in patients on maintenance dialysis.

7 Jan 2022

SARS-CoV-2 Omicron belongs to new antigenic cluster compared to all other VOCs

Researchers investigate SARS-CoV-2 antigenic drift by evaluating the neutralizing activity of sera from patients infected with all five SARS-CoV-2 VOCs.

6 Jan 2022

Scientists assess effectiveness of neutralizing antibodies against seven SARS-CoV-2 variants, including Omicron

Researchers determine the neutralization potency of serum from COVID-19-recovered patients and double-vaccinated individuals against SARS-CoV-2 variants.

6 Jan 2022

Antibody binding response significantly reduced for Omicron compared to other SARS-CoV-2 variants

Researchers analyzed ACE2-binding inhibition and antibody binding for the SARS-CoV-2 Omicron variants in individuals with varying levels of immunity.

6 Jan 2022

Study suggests that previous COVID-19 infections do not affect pregnancy

A new study shows that it is exceedingly likely that past infection with SARS-CoV-2 has no significant effect on antibody or cytokine levels during pregnancy, labor or delivery.

6 Jan 2022

Serological antibody response to SARS-CoV-2 infection at a population level

The scientists in this study used pooled convalescent serum to examine the serologic response in a population at risk of infection.

6 Jan 2022

Streamlined, efficient approaches to cell culture spectrometry and analysis

As demand for the high throughput production of high quality, highly specialized and reliable cell culture products continues to rise, laboratories and manufacturers need to move away from traditional manual analysis methods in favor of advanced real-time analysis using power spectroscopic methods.

From Thermo Fisher Scientific – Environmental and Process Monitoring Instruments 6 Jan 2022

Does SARS-CoV-2 Omicron variant elicited neutralizing immunity enhance that elicited by the Delta variant?

In this paper, researchers studied whether the neutralizing immunity produced by Omicron also increases neutralizing immunity of the Delta variant.

6 Jan 2022

Assay News and Research

SARS-CoV-2 spike engagement of ACE2 shown to prime S2′ site cleavage and fusion initiation

Engineered small extracellular vesicles for the neutralization of SARS-CoV-2

Bolstering current therapeutic antibody treatments to help fight Omicron infections

SARS-CoV-2 Omicron variant uses endosomal entry pathway and grows in upper respiratory tract cells

SARS‑CoV‑2 Omicron variant escapes monoclonal antibodies

Lab engineered human A549 lung cell model conducive for investigating SARS-CoV-2 antivirals

Dual-receptors help widespread dissemination of SARS-CoV-2

Booster mRNA vaccination effective in reviving anti-SARS-CoV-2 antibody titers among the elderly

Vaccine breakthrough COVID-19 infections found to be less likely transmitted

Reinfection with SARS-CoV-2 in children

Integrating Microplate Evaporators with Liquid Handling Robots

Broad cross-neutralization antibodies found to be effective against SARS-CoV-2 Omicron variant

Additional SARS-CoV-2 vaccine doses elicit robust seroresponse among patients receiving maintenance dialysis

SARS-CoV-2 Omicron belongs to new antigenic cluster compared to all other VOCs

Scientists assess effectiveness of neutralizing antibodies against seven SARS-CoV-2 variants, including Omicron

Antibody binding response significantly reduced for Omicron compared to other SARS-CoV-2 variants

Study suggests that previous COVID-19 infections do not affect pregnancy

Serological antibody response to SARS-CoV-2 infection at a population level

Streamlined, efficient approaches to cell culture spectrometry and analysis

Does SARS-CoV-2 Omicron variant elicited neutralizing immunity enhance that elicited by the Delta variant?

eBook: Using iPSCs models for human disease research and drug discovery eBook

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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