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FDA approves opioid agonist for management of moderate to severe acute pain in adults

Today, the U.S. Food and Drug Administration approved Olinvyk (oliceridine), an opioid agonist for the management of moderate to severe acute pain in adults, where the pain is severe enough to require an intravenous opioid and for whom alternative treatments are inadequate.

9 Aug 2020

Research identifies a potential therapeutic target for clogged arteries

New work led by Carnegie's Meredith Wilson and Steve Farber identifies a potential therapeutic target for clogged arteries and other health risks that stem from an excess of harmful fats in the bloodstream. Their findings are published by PLOS Genetics.

7 Aug 2020

Advanced analysis offers new insights into immune system’s role in severe COVID-19

By conducting advanced analyses of immune system activation in patients with severe COVID-19, researchers at Karolinska Institutet have managed to identify several cell types that play a key part in the immune response to the new coronavirus and the hyperinflammation seen in severe cases of the disease.

7 Aug 2020

Large-scale analysis of Alport syndrome reveals the effectiveness of existing treatments

A large-scale analysis of the clinical characteristics of Alport syndrome in Japanese patients has revealed that the effectiveness of existing treatment with ACE inhibitors and/or angiotensin receptor blockers (RAS inhibitors) varies depending on the type of mutation in the syndrome's causal gene (COL4A5).

7 Aug 2020

Study provides detailed insight into problems faced by patients recovering from COVID-19

Researchers have identified a pattern of longer-term symptoms likely to be experienced by people who were hospitalised with the COVID-19 infection.

7 Aug 2020

Humans promote diseases from the animal kingdom

The coronavirus pandemic, which has now infected nearly 19 million and killed more than 712,000 people, most likely originated from bats. Just like other coronavirus outbreaks in the past, a spill-over event or zoonosis caused the viruses to jump from animals to humans.

6 Aug 2020

Study shows recombination among SARS-CoV-2 strains is already occurring, but remains rare

A recent study by U.S. researchers, currently available on the bioRxiv preprint server, indicates that the recombination events among the viral strains of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are already occurring – however, considering current levels of viral genetic diversity, they are neither widespread nor readily detectable.

6 Aug 2020

Heat suggested as a therapeutic intervention in COVID-19

Viruses that are contained within a lipid membrane or “enveloped viruses” such as coronaviruses and rhinoviruses can remain active for long periods in cool, dry conditions, which can lead to increased rates of respiratory infections.

6 Aug 2020

COVID-19 in pregnancy - premature birth common

A new study conducted by researchers at Yonsei University College of Medicine, Korea, suggests that while having coronavirus disease 2019 (COVID-19) during pregnancy has little effect on fetal or neonatal mortality, it can be associated with premature birth and sometimes severe outcomes for mother and baby, including death.

6 Aug 2020

Specific gene impairment may also protect people with Down syndrome

Scientists from Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago discovered that a set of genes with decreased expression in individuals with Down syndrome may lead to clinical abnormalities in this population, such as poor muscle development and heart valve problems.

6 Aug 2020

Human encroachment into forest land caused bat CoV spillover and COVID-19 emergence

A new study published on the preprint server medRxiv in August 2020 discusses the root causes underlying the emergence of such infectious diseases following their crossover of the line separating animal viruses from human. This initial event is of enormous significance.

6 Aug 2020

Researchers shed new light on epigenetic changes associated with ADNP syndrome

A study led by the Seaver Autism Center for Research and Treatment at Mount Sinai found that two different blood epigenetic signatures associated with ADNP syndrome (also known as Helsmoortel-Van Der Aa syndrome) have only a modest correlation with clinical manifestations of the syndrome. The study results were published online August 5 in the American Journal of Human Genetics.

6 Aug 2020

Face masks protect from COVID-19 and other respiratory illnesses

Now a new study published on the preprint server medRxiv in August 2020, therefore, presents the results of a meta-analysis that takes account of the lack of compliance with mask-wearing in RCTs, as well as the lag between the event and the measurable effects.

6 Aug 2020

Cats susceptible to and potential reservoirs for novel coronavirus

The study published on the preprint server bioRxiv in August 2020 shows that this is indeed taking place, with pet cats being infected and passing on the infection to contacts. It also offers the chance to see how the disease progresses in a susceptible host.

6 Aug 2020

Recovered COVID-19 patients report hair loss months after infection

Several members of Survivor Corps, the Facebook support group of people who have had COVID-19, recently tackled about experiencing hair loss months after recovering from the wrath of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).

6 Aug 2020

Viable SARS-CoV-2 aerosols detected in a hospital room with COVID-19 patients

Now, a new study by researchers at the University of Florida highlights the role played by SARS-CoV-2 aerosols in disease transmission.

5 Aug 2020

High altitude may act as a protective factor against COVID-19

The analysis by researchers from Spain and Peru reveals that high altitude confers significant protection from coronavirus disease (COVID-19) infection and death – independent of the distance from the pandemic epicenter, population density, or poverty levels. The study is currently available on the medRxiv preprint server.

5 Aug 2020

Study reveals changes in transmissibility of SARS-CoV-2 due to D614G spike mutation

A recent research endeavor from the UK, currently available on the medRxiv preprint server, indicates that spike 614G variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) increases in frequency relative to 614D variant in a selective advantage manner – but without higher coronavirus disease (COVID-19) mortality rates.

5 Aug 2020

A SARS-CoV-2 assay using plant proteins

Researchers in South Africa have developed a serological assay that readily detects antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using recombinant viral proteins produced in plants.

5 Aug 2020

Evidence for antibody longevity in COVID-19 patients

A study led by researchers at the University of Toronto, Canada, has found evidence that immunoglobulin G (IgG) antibody responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are sustained for at least three months.

5 Aug 2020