ACROBiosystems presents CC chemokine receptor 8 (CCR8), which is predominantly expressed in lymphoid tissues and has also been detected in glomerular podocytes and human umbilical vein endothelial cells (HUVECs).
Brief information
Name: C-C chemokine receptor type 8
The target synonym is CDw198 Antigen, C-C, Chemokine (C-C) Receptor 8, CC Chemokine Receptor 8. CKR-8, C-C Motif, CC-CKR-8, CCR-8, CMKBRL2, Chemokine Receptor 8, C-C Chemokine Receptor Type 8, C-C Chemokine Receptor CHEMR1, C-C Chemokine Receptor-Like 1, C-C Chemokine Receptor-Like 2, C-C Chemokine Receptor Chemr1, CD_antigen = CDw198, Chemokine receptor-like 1, CKRL1, CKR-L1, CMKBR8, GPRCY6, GPR-CY6, TER1, CDw198, CY6
- Number of Drugs Introduced: None
- Number of Drugs in Clinical Trials: 12
- Latest Research Phase: Phase 2 Clinical
Licensing
Source: ACROBiosystems Inc
Project
Name |
Modality |
Therapeutic
Area |
Indications |
Stage |
Right
Available |
CCR8 Humanized
Antibody |
Bispecific
antibody |
Oncology/
Cancer |
Solid
Tumor |
Preclinical |
Global |
Part of bioactivity data
Expression analysis of human CCR8 on the HEK293/Human CCR8 Stable Cell Line was conducted using FACS. Cells were stained with an anti-human CCR8 antibody, followed by secondary staining with a PE-conjugated anti-human IgG antibody. This staining protocol was also applied to a negative control cell line for comparison.
CHEK-ATP140-Cell-based assay. Image Credit: ACROBiosystems Inc
Immobilized Human CCR8 Full-Length Protein-VLP (Cat. No. CC8-H52P4) at a concentration of 10 μg/mL (100 μL per well) binds to the Anti-CCR8 Antibody, Human IgG1, with a linear range of 0.078 to 2.5 μg/mL, as verified by quality control testing.
CC8-H52P4-SPR. Image Credit: ACROBiosystems Inc
Synonym name
Chemokine receptor 8 (CC), CD198, ChemR1, CKRL1, CKR-L1, CKRL1, CY6, GPR-CY6, GPR-CY6, and TER-1
Background
This entry focuses on the CC chemokine receptor 8 (CCR8), which is primarily found in lymphoid tissues but can also be detected in glomerular podocytes and human umbilical vein endothelial cells (HUVECs). CCR8 is linked with Th2 lymphocytes, crucial for allergic responses, and plays a role in lymphocyte activation, migration, proliferation, and differentiation, contributing to allergic conditions. This receptor binds to CCL1 (I-309) and CCL16 (liver-expressed chemokine) and has a strong affinity for three viral chemokines: vMIP-I, vMIP-II, and vMCC-I.