Six-transmembrane epithelial antigen of the prostate 1 (STEAP1) is a membrane protein that is significantly overexpressed on the cell surfaces of various human cancers, positioning it as a promising target for therapeutic strategies. It shows sequence similarity to three enzymes (STEAP2-STEAP4) that are involved in the NADPH-dependent reduction of iron(III). Due to its high specificity and notable overexpression in cancer cells, STEAP1 is an emerging candidate for targeted cancer treatments.
Brief information
- Name: Six-transmembrane epithelial antigen of the prostate 1
- Target Synonym: PRSS24, Six-transmembrane epithelial antigen of prostate 1, STEAP, STEAP1, STEAP Family Member 1, Six Transmembrane Epithelial Antigen Of The Prostate 1, STEAP1 Metalloreductase, Six Transmembrane Epithelial Antigen Of The Prostate, Metalloreductase STEAP1, EC 1.16.1.-, EC:1.16.1.-
- Number of Launched Drugs: 0
- Number of Drugs in Clinical Trials: 4
- Lastest Research Phase: Phase 2 Clinical
Part of bioactivity data
CHEK-ATP154-Cell-based assay. Image Credit: ACROBiosystems Inc.
FACS analysis of STEAP1 in the HEK293/Human STEAP1 Stable Cell Line shows effective binding of the Anti-STEAP1 antibody to cells expressing Human STEAP1, as evidenced by the red line. The negative control HEK293 cells are depicted by the grey line (QC tested).
SCCHO-ATP121-Cell-based assay. Image Credit: ACROBiosystems Inc
Expression analysis of human STEAP1 on the CHO/Human STEAP1 Stable Cell Line was conducted using FACS. The cell surface was stained with an anti-human STEAP1 antibody, followed by secondary staining with a PE-conjugated anti-human IgG Fc antibody. This approach was also applied to a negative control cell line for comparison.
ST1-H5283-MALS-HPLC. Image Credit: ACROBiosystems Inc
Human STEAP1 Full-Length Protein, Twin-Strep, His Tag (Cat. No. ST1-H5283), captured on a CM5 chip via an anti-His antibody, binds to the Anti-STEAP1 Antibody with an affinity constant of 3.43 nM, as determined by SPR assay in the presence of DDM and CHS using a Biacore 8K system. This interaction is routinely tested.
Synonym name