Prominin-1, also known as CD133, Antigen AC133, PROM1, PROML1, and MSTP061, is a marker used for hematopoietic stem and progenitor cells (HSPC) in somatic stem cell isolation. It can play a role in cell differentiation, proliferation, and apoptosis. Prominin-1 binds cholesterol in cholesterol-containing plasma membrane microdomains and can also be involved in the organization of the apical plasma membrane in epithelial cells.
During early retinal development, it acts as a key regulator of disk morphogenesis. Additionally, it is involved in the regulation of the MAPK and Akt signaling pathways. In neuroblastoma cells, Prominin-1 suppresses cell differentiation, such as neurite outgrowth, in a RET-dependent manner.
Brief information
Name: CD133
Target Synonym: Antigen AC133, Prominin-1, PROMININ 1, PROMININ-Like Protein 1, PROML1, Stargardt Disease 4 (Autosomal Dominant), Hematopoietic Stem Cell Antigen, Macular Dystrophy, Retinal 2, Prominin (Mouse)-Like 1, CD133 Antigen, HProminin, MSTP061, CORD12, AC133, CD133, MCDR2, STGD4, RP41, AC133 Antigen
Number of
- Launched drugs: 0
- Number of Drugs in Clinical Trials:1
- Lastest Research Phase: Phase 2 Clinical
Part of bioactivity data
CD3-H52H1-cell-based assay
2e5 of Anti-CD133 CAR-293 cells were stained with 100 μL of 3 μg/mL of Human CD133 Full Length Protein, His Tag (Cat. No. CD3-H52H1) and negative control protein respectively, washed and then followed by PE-anti-His Tag antibody and analyzed with FACS (QC tested). Image Credit: ACROBiosystems Inc
CD3-H52H1-ELISA
Immobilized Human CD133 Full Length Protein, His Tag (Cat. No. CD3-H52H1) at 1 μg/mL (100 μL/well) can bind Monoclonal Anti-Human CD133 Antibody, Human IgG1 with a linear range of 0.2-4 ng/mL (QC tested). Image Credit: ACROBiosystems Inc
CD3-H52P3-ELISA
Immobilized Human CD133 Full Length-VLP (Cat. No. CD3-H52P3) at 1 μg/mL (100 μL/well) can bind Monoclonal Anti-Human CD133 Antibody, Mouse IgG1 with a linear range of 0.2-4 ng/mL (QC tested). Image Credit: ACROBiosystems Inc
Synonym name
AC133, CD133, PROM1, PROML1, and Prominin-1