Claudin-18.2 highly selective gastric lineage marker

Among the two CLDN18 isoform transcripts produced through alternative splicing, CLDN18.2 serves as a highly selective marker for gastric lineage, indicating the gastric phenotype in neoplastic conditions, while CLDN18.1 is specific to the lung

Brief information

Name: Claudin-18 splice variant 2

Target Synonym: CLDN18, Claudin 18, UNQ778/PRO1572, Pulmonary Associated Protein J, Surfactant Associated 5, and Surfactant Associated JClaudin-18, SFTPJ, Claudin 18.2, SFTA5, and CLDN18.2

Number of Drugs in Clinical Trials: 61

Number of Launched Drugs: 1

Latest Research Phase: Approved

Antibody licensing

Source: ACROBiosystems Inc

Licensing

Source: ACROBiosystems Inc

Part of bioactivity data

CL2-HF218-Cell-based assay. 2e5 of Anti-Claudin-18.2 CAR-293 cells were stained with 100 μL of 3 μg/mL of Fluorescent Human Claudin-18.2 Full Length Protein-VLP (Cat. No.CL2-HF218) and negative control protein respectively, FITC signals was used to evaluate the binding activity (QC tested). Image Credit: ACROBiosystems Inc

CHEK-ATP033-Cell-based assay. FACS assay shows that Anti-Claudin-18.2 antibody can bind to HEK293/Human Claudin-18.2 Stable Cell Line. HEK293/Human Claudin-18.2 stable cells was red line, Negative control HEK293 cells was grey line (QC tested). Image Credit: ACROBiosystems Inc

CL2-H5586-SPR. Monoclonal Anti-Chimeric Claudin-18.2 Antibody, Human IgG1 captured on Protein A Chip can bind Human / Cynomolgus Claudin-18.2, His,Twin-Strep Tag (Cat. No. CL2-H5586) with an affinity constant of 12.6 nM as determined in SPR assay (Biacore 8K) (Routinely tested). Image Credit: ACROBiosystems Inc

CL2-M5585-SPR. Claudin-18.1 Monoclonal Antibody captured on CM5 chip via anti-mouse antibodies surface can bind Mouse Claudin-18.2, His,Twin-Strep Tag (Cat. No. CL2-M5585) with an affinity constant of 13 nM as determined in a SPR assay (in presence of DDM and CHS) (Biacore 8K) (Routinely tested). Image Credit: ACROBiosystems Inc

Synonym name

Claudin-18.2, CLDN18, Claudin-18

Background

Claudins (CLDNs) are a group of proteins that form tight junctions, crucial for maintaining the polarity of epithelial and endothelial cells. CLDN18 is specifically expressed in the stomach and lungs.

Among the two isoforms of CLDN18 produced through alternative splicing, CLDN18.2 serves as a highly selective marker for gastric lineage, playing a role in defining the gastric phenotype in neoplastic conditions. In contrast, CLDN18.1 is specific to the lungs.

CLDN18.2 is expressed exclusively on short-lived, differentiated gastric epithelial cells, limiting its accessibility to antibody drugs. However, CLDN18.2 is preserved during malignant transformation and is commonly found on the surface of human gastric cancer cells.