Biochemistry

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Newly discovered toxin stands out from others in the battle for microbial domination

A newly discovered toxin that some bacteria deploy to fend off competing bacteria stands out from others in the battle for microbial domination. While many deadly substances have been identified among bacteria, this previously unknown toxin behaves in a familiar way.

19 Oct 2018

UT Southwestern biochemist receives 2019 Breakthrough Prize in Life Sciences for innate immunity discovery

UT Southwestern biochemist Dr. Zhijian "James" Chen today was named winner of the prestigious 2019 Breakthrough Prize in Life Sciences for his discovery of the cGAS enzyme that launches the body's immune defense against infections and cancers.

19 Oct 2018

Using Galleria mellonella to assess acute toxicity of chemicals

TruLarv is considered a non-animal technology in the context of UK animal use regulations where procedures on this species are not regulated.

17 Oct 2018

Determining acid-neutralizing capacity for OTC antacids

USP<301> describes a back-titration to determine the acid-neutralizing capacity (ANC).

From Metrohm USA Inc. 17 Oct 2018

Yale researchers develop way to attack RNA with small-molecule drugs

Yale researchers have developed a way to target RNA with small-molecule drugs, creating a new method for tapping into a vast number of biological mechanisms critical to metabolism and gene expression.

15 Oct 2018

Researchers demonstrate integrated technique to control production of cell therapeutics

Researchers have demonstrated an integrated technique for monitoring specific biomolecules - such as growth factors - that could indicate the health of living cell cultures produced for the burgeoning field of cell-based therapeutics.

15 Oct 2018

Ohio State chemists develop new, improved way to generate molecules for drug development

Chemists at The Ohio State University have developed a new and improved way to generate molecules that can enable the design of new types of synthetic drugs.

12 Oct 2018

'Digital brain' recreates protein trafficking in the brain

Researchers have developed a digital 3D brain demonstrating how the toxic proteins involved in neurodegenerative diseases are transported through the brain.

12 Oct 2018

Scientists reprogram mature inhibitory neurons into dopaminergic cells

Attempting to make dopamine-producing neurons out of glial cells in mouse brains, a group of researchers instead converted mature inhibitory neurons into dopaminergic cells.

12 Oct 2018

Researchers uncover how common pain reliever causes liver failure

Acetaminophen is a common pain reliever found in every pharmacy. However, it is also the No. 1 cause of acute liver failure in the United States. In the liver, acetaminophen is converted into a new compound that covalently binds to proteins at an amino acid called cysteine.

11 Oct 2018

DNA vaccine shown to provide long-term protection from Ebola

A synthetic DNA vaccine has been shown to provide complete and enduring protection from Ebola virus in preclinical studies.

11 Oct 2018

Louisiana amphibian shows resistance to skin disease caused by fungus

Amphibian populations around the world are declining due to a skin disease caused by fungus. However, an amphibian commonly found in Louisiana, the three-toed amphiuma, has shown a resistance to the fungus, in a new study led by researchers at LSU, Southeastern Louisiana University, Duquesne University and the University of Washington.

10 Oct 2018

'Molecular baskets' show promise to trap deadly nerve agents and toxic compounds

Researchers have developed designer molecules that may one day be able to seek out and trap deadly nerve agents and other toxic compounds in the environment - and possibly in humans.

10 Oct 2018

Nanopore technology combined with DNA computing to catch early biomarkers for small cell lung cancer

Small Cell Lung Cancer is very aggressive, since the cancer cells not only quickly grow but also easily spread to entire body. Often SCLC can be diagnosed using several common tests unfortunately after spread of cancer cells, resulting in poor survival.

7 Oct 2018

Amputation injury is reflected in bioelectric properties of opposing, undamaged limb

In research that extends knowledge about the physiology of regeneration and wound repair, Tufts University biologists have discovered that amputation of one limb is immediately reflected in the bioelectric properties of the contralateral, or opposing, undamaged limb of developing frogs.

5 Oct 2018

A Single Platform to Sequence All Monoclonal Antibody Proteins

Having a single platform to sequence all monoclonal antibody proteins provides researchers with key information for research, development and drug discovery

From Rapid Novor Inc 3 Oct 2018

Molecule research reveals potential drug target for treating stroke patients

In an extension of research published a month ago in Nature Methods, a novel hybrid approach performed by researchers from Clemson University's department of physics and astronomy and Stony Brook University has revealed a 3-D structure of a protein fragment that could serve as a drug target in treating stroke patients.

3 Oct 2018

Study highlights need for population-specific precision medicine programs in Latin America

Drug safety and effectiveness vary greatly among populations worldwide. Genetics is one of the factors that contribute to variability in drug response.

3 Oct 2018

Researchers start to understand how to make lab-grown heart cells mature

Scientists at Boston Children’s Hospital have made important steps towards overcoming the hurdles that stand in the way of getting heart muscle to regenerate following engraftment with lab-made heart muscle cells (cardiomyocytes).

28 Sep 2018

Researchers develop new mathematical technique to study brain waves

A U.S. Army Research Laboratory scientist has collaborated with a team of researchers from the University of North Texas to develop a new data processing technique that uses electroencephalogram, or EEG, time series variability as a measure of the state of the brain.

27 Sep 2018

Biochemistry

Newly discovered toxin stands out from others in the battle for microbial domination

UT Southwestern biochemist receives 2019 Breakthrough Prize in Life Sciences for innate immunity discovery

Using Galleria mellonella to assess acute toxicity of chemicals

Determining acid-neutralizing capacity for OTC antacids

Yale researchers develop way to attack RNA with small-molecule drugs

Researchers demonstrate integrated technique to control production of cell therapeutics

Ohio State chemists develop new, improved way to generate molecules for drug development

'Digital brain' recreates protein trafficking in the brain

Scientists reprogram mature inhibitory neurons into dopaminergic cells

Researchers uncover how common pain reliever causes liver failure

DNA vaccine shown to provide long-term protection from Ebola

Louisiana amphibian shows resistance to skin disease caused by fungus

'Molecular baskets' show promise to trap deadly nerve agents and toxic compounds

Nanopore technology combined with DNA computing to catch early biomarkers for small cell lung cancer

Amputation injury is reflected in bioelectric properties of opposing, undamaged limb

A Single Platform to Sequence All Monoclonal Antibody Proteins

Molecule research reveals potential drug target for treating stroke patients

Study highlights need for population-specific precision medicine programs in Latin America

Researchers start to understand how to make lab-grown heart cells mature

Researchers develop new mathematical technique to study brain waves

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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