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KHN’s ‘What the Health?’: Delta blues

The U.S. is experiencing another surge of covid-19, particularly in Southern states where vaccination rates are generally lower than in other regions. But partisan fights rage on over what role government should play in trying to tamp down the highly contagious delta variant.

5 Aug 2021

A correlation study between time-from-vaccine and SARS-CoV-2 breakthrough infections

A new retrospective study compares the incidence rates of breakthrough infections between different time points at which individuals were vaccinated.

5 Aug 2021

Invasive 'famine weed' could escalate the spread of malaria

An invasive weed could escalate the spread of malaria in East Africa after scientists found new evidence that it creates a favourable breeding ground for female mosquitoes, which transmit malaria.

5 Aug 2021

Vaccinia-based COVID-19 vaccines confer immunity in hamster model

In a paper recently uploaded to the preprint server bioRxiv* by Kulkarni et al. (August 3, 2021), the potential of vaccinia virus-based vaccines expressing the full-length SARS-CoV-2 spike protein is examined in mice and Syrian hamsters. The findings report that the vaccine generates high titers of neutralizing antibodies with good activity towards SARS-CoV-2 variants of concern.

5 Aug 2021

New study examines B cell receptor repertoires in COVID-19 patients

In a paper recently uploaded to the preprint server bioRxiv* by Kim et al. (August 2, 2021), the B cell receptor repertoire of 1,060 COVID-19 patients is compared to that of an equal number of healthy volunteers in a novel manner, utilizing computational deep-learning-based protein embedding techniques, which demonstrate a resolution capable of tracking the changes in immunity in an individual over the course of infection.

5 Aug 2021

Immunocompromised patients could be potential hosts for immune-escape mutants of SARS-CoV-2

In a recently published article in The New England Journal of Medicine, scientists have described how multi-mutational variants of SARS-CoV-2 may evolve in patients with immunosuppression.

5 Aug 2021

How does the mRNA/lipid nanoparticle platform promote protective adaptive immunity against SARS-CoV-2?

Modified mRNA combined with lipid nanoparticles may be beneficial in boosting adaptive immunity against SARS-CoV-2. Research led by Botond Z. Igyártó from Thomas Jefferson University’s Department of Microbiology and Immunology in Pennsylvania recently found that the lipid nanoparticles induce protective adaptive immune responses with antibody titers against lethal doses of the virus.

5 Aug 2021

Could a plant metabolite in liverworts be a potent antiviral against SARS-CoV-2 and other RNA viruses?

A new study from the National Centre for Biotechnology and Medicinal Chemistry Institute suggests Mother Nature delivered — in the form of liverworts. They found that the bryophyte Marchantia polymorpha, also known as umbrella liverworts, could work as a potential antiviral treatment.

5 Aug 2021

Post-COVID-19 neurological sequalae are not due to brain injury, study shows

In a recent study from University of Gothenburg, it has been shown that all participants achieve normalization of CNS injury biomarkers, regardless of previous disease severity or persistent neurological symptoms. Indicating that post-COVID-19 neurological sequalae are not due to active brain injury.

5 Aug 2021

Two monoclonal antibodies broadly neutralize SARS-CoV-2 variants of concern

Researchers in the United States and Canada have described the structural basis and mode of action for two monoclonal antibodies that potently neutralize severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

4 Aug 2021

Monoclonal antibody could inform development of pan-coronavirus vaccines

Researchers in the United States have demonstrated the potential of a monoclonal antibody to inform the design of pan-coronavirus vaccines that could prevent the outbreak of future pandemics such as coronavirus disease 2019 (COVID-19).

4 Aug 2021

The role of natural killer cells in the fight against coronavirus infection

This study proposes a mathematical framework to analyze the effect of the viruses on type I interferon (IFN-I) signaling, which is part of the innate immune response. IFN-I brings about natural killer cell activation, which in turn causes the activation of macrophages.

4 Aug 2021

New LSHTM spin-out company aims to improve detection and control of infectious diseases

Two spin-out companies from the London School of Hygiene & Tropical Medicine (LSHTM) have merged to form a new company that will improve the detection and control of infectious diseases.

4 Aug 2021

Initiating therapeutic anticoagulation benefits moderately ill COVID-19 patients, but not critically ill patients

A large clinical trial conducted worldwide shows that treating moderately ill hospitalized COVID-19 patients with a full-dose blood thinner reduced their need for organ support, such as mechanical ventilation, and improved their chances of leaving the hospital.

4 Aug 2021

Disease/Infection News

KHN’s ‘What the Health?’: Delta blues

A correlation study between time-from-vaccine and SARS-CoV-2 breakthrough infections

Invasive 'famine weed' could escalate the spread of malaria

Vaccinia-based COVID-19 vaccines confer immunity in hamster model

New study examines B cell receptor repertoires in COVID-19 patients

Immunocompromised patients could be potential hosts for immune-escape mutants of SARS-CoV-2

How does the mRNA/lipid nanoparticle platform promote protective adaptive immunity against SARS-CoV-2?

Could a plant metabolite in liverworts be a potent antiviral against SARS-CoV-2 and other RNA viruses?

Post-COVID-19 neurological sequalae are not due to brain injury, study shows

Two monoclonal antibodies broadly neutralize SARS-CoV-2 variants of concern

Monoclonal antibody could inform development of pan-coronavirus vaccines

The role of natural killer cells in the fight against coronavirus infection

New LSHTM spin-out company aims to improve detection and control of infectious diseases

Initiating therapeutic anticoagulation benefits moderately ill COVID-19 patients, but not critically ill patients

Reducing antibiotic prescribing in primary care alone may not stop drug-resistant E. coli infections

Tangible mental health support needed for hospital workers dealing with Covid pandemic

Flu vaccine may provide vital protection against COVID-19, study shows

Study finds only 15% of rural health care workers have SARS-CoV-2 antibodies

REACT-1 study: COVID-19 infection rates three times lower for double vaccinated people

LEDs can help inactivate SARS-CoV-2 virus

Advancing brain microphysiological systems (bMPS)

PhD researcher at LifeArc

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

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