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SARS-CoV-2 South Africa and Brazil variants show resistance to therapeutic antibodies

Scientists from Germany have determined the efficacy of currently used therapeutics in treating newer variants of SARS-CoV-2, including the UK, South Africa, and Brazil variants. Their findings reveal that both B.1.351 and B.1.1.248 variants are able to escape humoral immune responses induced by therapeutic antibodies, vaccinations, or natural SARS-CoV-2 infection.

15 Feb 2021

RIG-1-like receptors may play dominant role in suppressing SARS-CoV-2 infection

A new study by researchers at the University of Connecticut Health Center, USA, reports the crucial nature of the pathogen pattern recognition receptor (PRRs), especially the two RLRs, retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated protein 5 (MDA5), in triggering host cell immune responses within the cell. The RLRs are viral RNA sensors.

15 Feb 2021

Researchers develop protocols for rapid serological surveys of SARS-CoV-2 infection

A new study by researchers from Emory and Yale Universities in the USA discusses a design for quickly launching serological surveys to assess the prevalence of this infection in a given population.

15 Feb 2021

LifeArc supports the GenOMICC COVID-19 Study

Medical research charity, LifeArc, announces today that it is providing £5 million funding to support the work of the GenOMICC COVID-19 Study, led by the GenOMICC consortium in partnership with Genomics England.

15 Feb 2021

Immunosuppressive therapies may be linked to severe COVID-19 in those with multiple sclerosis

A new study examines the associations between immunosuppressive disease-modifying therapies (DMTs) used in MS with adverse outcomes in an international cohort of patients with MS COVID-19.

15 Feb 2021

Researchers study host and viral transcriptomes in tandem to shed light on SARS-CoV-2 infection

In a new study, researchers discuss the use of simultaneous sequencing of both human and viral genes to better understand SARS-CoV-2's infection pathway.

15 Feb 2021

A machine learning approach to identify drugs that could be repurposed to fight COVID-19

When the Covid-19 pandemic struck in early 2020, doctors and researchers rushed to find effective treatments. There was little time to spare.

15 Feb 2021

Nanobodies protect against SARS-CoV-2 variants in animal model

Nanobodies are a potential therapeutic strategy for treating COVID-19. While many previous studies report nanobodies active against SARS-CoV-2 in vitro, none have been evaluated via animal models' intranasal administration.

15 Feb 2021

Only 25% of SARS-CoV-2 infections are detected in the UK: Study

A new preprint research paper posted to the medRxiv server estimates the number of infections that are diagnosed from testing alone as being about a fourth of the total.

15 Feb 2021

Humidity created inside the face masks may help combat COVID-19

Masks help protect the people wearing them from getting or spreading SARS-CoV-2, the virus that causes COVID-19, but now researchers from the National Institutes of Health have added evidence for yet another potential benefit for wearers: The humidity created inside the mask may help combat respiratory diseases such as COVID-19.

14 Feb 2021

Premature relaxation of restrictions following SARS-CoV-2 vaccination could lead to new mutations

A new preprint research paper posted to the medRxiv* server addresses the need to assess this risk by examining whether SARS-CoV-2 transmission can interact with vaccination rates to select vaccine-resistant strains. The study aims to provide data to shape effective countermeasures against the threat of viral resistance.

14 Feb 2021

Naïve B cells can neutralize SARS-CoV-2 via RBD recognition

A new preprint research paper posted to the bioRxiv server demonstrates the potential of using the pre-existing protective responses to produce a broad-spectrum neutralizing response against not just SARS-CoV-2 but other future pathogens.

14 Feb 2021

New mouse model of SARS-CoV-2 infection reflects features of human infection

Now, a new preprint research paper posted to the bioRxiv server reports the development of a modified mouse model that allows productive SARS-CoV-2 infection of the mouse lungs, as well as the exploration of type I and III interferon responses in this condition.

14 Feb 2021

SARS-CoV-2's resistance to remdesivir in vitro

A new preprint research paper posted to the bioRxiv server discusses the emergence of mutations in the SARS-CoV-2 virus, allowing it to escape the effects of the most commonly used antiviral drug, remdesivir.

14 Feb 2021

SARS-CoV-2 was in NYC a good month before it was first identified, say researchers

Researchers at Icahn School of Medicine at Mount Sinai in New York have provided evidence suggesting that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19) – was infecting people in New York City (NYC) at least one month before the first case was officially documented in the city.

14 Feb 2021

Vaccine candidate containing tetanus toxoid potentially protective against SARS-CoV-2

Researchers from Cuba, China, and France have demonstrated the potential of coupling a viral antigen with the tetanus toxoid protein as a vaccination approach to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

14 Feb 2021

Disease/Infection News

SARS-CoV-2 South Africa and Brazil variants show resistance to therapeutic antibodies

RIG-1-like receptors may play dominant role in suppressing SARS-CoV-2 infection

Researchers develop protocols for rapid serological surveys of SARS-CoV-2 infection

LifeArc supports the GenOMICC COVID-19 Study

Immunosuppressive therapies may be linked to severe COVID-19 in those with multiple sclerosis

Researchers study host and viral transcriptomes in tandem to shed light on SARS-CoV-2 infection

A machine learning approach to identify drugs that could be repurposed to fight COVID-19

Nanobodies protect against SARS-CoV-2 variants in animal model

Only 25% of SARS-CoV-2 infections are detected in the UK: Study

Humidity created inside the face masks may help combat COVID-19

Premature relaxation of restrictions following SARS-CoV-2 vaccination could lead to new mutations

Naïve B cells can neutralize SARS-CoV-2 via RBD recognition

New mouse model of SARS-CoV-2 infection reflects features of human infection

SARS-CoV-2's resistance to remdesivir in vitro

SARS-CoV-2 was in NYC a good month before it was first identified, say researchers

Vaccine candidate containing tetanus toxoid potentially protective against SARS-CoV-2

Study reveals the effects of school closures on SARS-CoV-2 transmission among parents, teachers

New Cochrane Review: Hydroxychloroquine does not reduce deaths from COVID-19

How effective has the COVID-19 vaccination program been in Israel?

Scientists demonstrate how glue points and sequence alignment information can flag residue SARS-CoV-2 variants

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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