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A new potential COVID-19 vaccine candidate: YF-S0

A recent study published in the journal Nature describes the safety and efficacy of a live-attenuated yellow fever 17D (YF17D) vector-based vaccine candidate expressing a non-cleavable form of the spike protein of severe acute respiratory coronavirus 2 (SARS-CoV2).

2 Dec 2020

Genethon to start international clinical trial for treatment of Duchenne muscular dystrophy

Genethon, dedicated to designing and developing gene therapy products for rare diseases, received this Monday 30th of November the authorization from the ANSM, the French National Agency for Medicines and Health Products Safety, to start in France a multicentre international clinical trial for the treatment of Duchenne muscular dystrophy with product GNT 004.

2 Dec 2020

Nucleic acid-hydrolyzing scFv 3D8 exhibits potent antiviral effects on SARS-CoV-2

3D8, a 27-kDa recombinant antibody fragment, was found in autoimmune-prone Murphy Roths Large mice. The single-chain variable fragment (scFv) has the nucleic acid hydrolyzing activity and is shown to degrade DNA or mRNA of viruses in infected cells.

30 Nov 2020

Marinomed plans a clinical trial with Carragelose nasal spray as COVID-19 prophylaxis

Marinomed Biotech AG, a globally operating biopharmaceutical company, is pleased to announce today that the Swansea University Medical School plans a clinical trial with Iota-/kappa-carrageenan nasal spray as a COVID-19 Prophylaxis for Healthcare Professionals (ICE-COVID).

30 Nov 2020

Rutgers leading a clinical trial assessing combination treatment for coronavirus

Rutgers is leading a clinical trial assessing the combination of nitazoxanide, ribavirin and hydroxychloroquine to treat people 21 or older who are infected with SARS-CoV-2 and are asymptomatic or mildly symptomatic.

30 Nov 2020

UC San Diego chosen to lead an international $28-million grant for HIV/AIDS clinical trials

University of California San Diego Collaborative Clinical Trials Unit has been selected by the National Institutes of Health to lead and administer an international seven-year, $28-million grant for science-driven clinical trials that deliver innovative, efficient results needed to turn the corner on the HIV/AIDS pandemic.

30 Nov 2020

What are the risks associated with human challenge trials for SARS-CoV-2 vaccine candidates?

Researchers from the University of Haifa, Israel, and WAW Statistical Consulting Ltd, UK, designed a model that helps determine the risks faced by participants in a hypothetical COVID-19 dosing study.

30 Nov 2020

Early interferon therapy may mitigate COVID-19 severity

A recent review of COVID-19 therapies explores the utility of interferons in the battle against severe COVID-19, and concludes that they deserve further development.

26 Nov 2020

COVID-19 vaccine candidate tested preclinically at UAB poised for Phase 1 clinical study

A COVID-19 vaccine candidate that underwent extensive preclinical testing at the University of Alabama at Birmingham this spring and summer is poised for clinical testing to begin in December.

25 Nov 2020

New drug treatment could soon benefit people with rheumatoid arthritis

People with Rheumatoid Arthritis (RA) could soon benefit from a new drug treatment that not only suppresses inflammation but also significantly reduces patient reported pain scores. Otilimab is a monoclonal antibody, biologic drug, which targets and suppresses the inflammatory cytokine GM-CSF.

25 Nov 2020

Mefloquine shows potential as anti-SARS-CoV-2 drug

A team of scientists from Japan has identified the approved anti-material drug, mefloquine, as a potential candidate to treat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Specifically, mefloquine has been shown to prevent the entry of SARS-CoV-2 into host cells and reduce the viral load in vitro.

24 Nov 2020

Largest clinical trial launched to treat mild-to-moderate COVID-19 patients in Africa

Thirteen African countries and an international network of research institutions have joined forces to launch the largest COVID-19 clinical trial in mild-to-moderate outpatients in Africa.

24 Nov 2020

Marinomed to initiate clinical trial with Carragelose for preventing COVID19 in frontline healthcare staff

Marinomed Biotech AG, a globally operating biopharmaceutical company, announced today plans to initiate a Phase IV clinical trial with Carragelose (iota-carrageenan).

23 Nov 2020

Favorable clinical outcome for ivermectin in COVID-19 animal model

A team of researchers at the Institut Pasteur in France has found that ivermectin prevented clinical deterioration in infected animals. The drug also reduced the inflammatory cytokines, interleukin-6 and 10 (IL-6 and IL-10) in lung tissue, which leads to more favorable clinical outcomes in treated animals.

23 Nov 2020

The Prospects of Semaglutide for Treatment of Type 2 Diabetes Patients

In this interview, News-Medical talks to Dr. Jan Westerink about recent studies into Novo Nordisk’s semaglutide and its potential benefits for Type 2 Diabetes patients, that he and Novo Nordisk collaborated on.

From Syneos Health 20 Nov 2020

Sinovac Biotech's COVID-19 vaccine candidate triggers immune response

Now, Sinovac Biotech's candidate vaccine, CoronaVac, has been found to induce an immune response in healthy adults aged 18–59 years, 28 days post-vaccination. However, the level of antibodies generated was lower than in people who had recovered from the illness.

19 Nov 2020

New combination treatment for recurrent ovarian cancer shows positive outcomes

A team from Roswell Park Comprehensive Cancer Center has detailed striking findings on the effectiveness of a previously untried combination of old and new drugs as treatment for recurrent ovarian cancer.

19 Nov 2020

NIH-funded study to test emergency treatment for devastating stroke in Memphis

The University of Tennessee Health Science Center's Stroke Team is joining researchers from more than 100 hospitals worldwide to conduct a National Institutes of Health (NIH)-funded research study called FASTEST that will test the safety and efficacy of a medication called recombinant factor Vlla to prevent hemorrhage expansion in patients with strokes caused by bleeding in the brain - intracerebral hemorrhage strokes.

19 Nov 2020

New findings support current and planned clinical trials of Janssen SARS-CoV-2 vaccine

Researchers from the United States and The Netherlands have conducted a pre-clinical study supporting the initiation of a Phase 3 trial to test a two-dose regimen of the Janssen Ad26.COV2.S vaccine candidate among adult and elderly individuals.

19 Nov 2020

UK’s COVID-19 vaccine shows similar safety and immunogenicity results in healthy older adults

The UK's vaccine against SARS-CoV-2 shows similar safety and immunogenicity results in healthy older adults (aged 56 years and over) to those seen in adults aged 18-55 years.

19 Nov 2020

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Drug Trial News

A new potential COVID-19 vaccine candidate: YF-S0

Genethon to start international clinical trial for treatment of Duchenne muscular dystrophy

Nucleic acid-hydrolyzing scFv 3D8 exhibits potent antiviral effects on SARS-CoV-2

Marinomed plans a clinical trial with Carragelose nasal spray as COVID-19 prophylaxis

Rutgers leading a clinical trial assessing combination treatment for coronavirus

UC San Diego chosen to lead an international $28-million grant for HIV/AIDS clinical trials

What are the risks associated with human challenge trials for SARS-CoV-2 vaccine candidates?

Early interferon therapy may mitigate COVID-19 severity

COVID-19 vaccine candidate tested preclinically at UAB poised for Phase 1 clinical study

New drug treatment could soon benefit people with rheumatoid arthritis

Mefloquine shows potential as anti-SARS-CoV-2 drug

Largest clinical trial launched to treat mild-to-moderate COVID-19 patients in Africa

Marinomed to initiate clinical trial with Carragelose for preventing COVID19 in frontline healthcare staff

Favorable clinical outcome for ivermectin in COVID-19 animal model

The Prospects of Semaglutide for Treatment of Type 2 Diabetes Patients

Sinovac Biotech's COVID-19 vaccine candidate triggers immune response

New combination treatment for recurrent ovarian cancer shows positive outcomes

NIH-funded study to test emergency treatment for devastating stroke in Memphis

New findings support current and planned clinical trials of Janssen SARS-CoV-2 vaccine

UK’s COVID-19 vaccine shows similar safety and immunogenicity results in healthy older adults

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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