Molecular & Structural Biology

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Pox viruses deliver proteins that directly interfere with the body's innate immune system

Pox viruses are able to get a head start on infecting a host by delivering a package of proteins that directly interferes with the body's innate immune system.

15 Jul 2022

Brain encodes the structure of sentences and phrases into different neural firing patterns, study finds

Our brain links incoming speech sounds to knowledge of grammar, which is abstract in nature. But how does the brain encode abstract sentence structure?

15 Jul 2022

New transport system exemplifies the potential of a de novo design of peptides and proteins

A novel peptide developed at the Universities of Bayreuth and Bristol is eminently suited for the targeted transport of molecules, for example of active substances and dyes, into the cells of mammals.

14 Jul 2022

Study discovers the most complex knotted protein to date

The question of how the chemical composition of a protein, the amino acid sequence, determines its 3D structure has been one of the biggest challenges in biophysics for more than half a century.

14 Jul 2022

SARS-Arena reveals conserved parts of viral proteins that cause COVID-19

Vaccines may need to dig a little deeper to stop SARS-CoV-2. Rice University researchers are providing a new shovel.

14 Jul 2022

Prion imaging could lead to better understanding of what causes fatal neurological disorders

Prion diseases are incurable, deadly neurological disorders that can affect both humans and animals–including Creutzfeldt-Jakob Disease (CJD) in people, Bovine Spongiform Encephalopathy (also known as Mad Cow Disease) and Chronic Wasting Disease found in deer.

13 Jul 2022

Study identifies a protein that plays key role in protecting the gastrointestinal tract from inflammation

A protein called Zbtb46, expressed by specialized immune cells, has a major role in protecting the gastrointestinal tract from excessive inflammation, according to a study from researchers at Weill Cornell Medicine.

13 Jul 2022

Study reveals a specific metabolic adaptation in some patients with acute myeloid leukemia

An article published in the journal Nature Communications describes a specific metabolic adaptation in some patients with acute myeloid leukemia affected by tandem mutations in the FLT3 gene.

13 Jul 2022

New regulatory code of protein glycosylation

Many proteins in nature exist as glycoproteins, which consist of protein (polypeptide chain) and glycan (sugar chain).

13 Jul 2022

Researchers gain unexpected insights into activation mechanism of flaviviruses

A collaboration between researchers at the Center for Virology of the Medical University of Vienna and the Pasteur Institute in Paris has provided unexpected insights into the atomic interactions of the tick-borne encephalitis (TBE) virus in infected cells.

13 Jul 2022

Ancestral molecule from bacteria-like cells may offer evolutionary insight on sexual reproduction

A study from Karolinska Institutet in Sweden, among others, presents the theory that egg-sperm fusion, a crucial feature of sexual reproduction in plants and animals, may have originated from an ancient form of genetic exchange that involved the fusion of bacteria-like microorganisms called archaea.

12 Jul 2022

Stinging nettle extract inhibits SARS-CoV-2 cell fusion

In a recent study posted to the bioRxiv* preprint server, researchers at Ghent University and KU Leuven, Belgium, demonstrated that Urtica dioica agglutinin (UDA), a monomeric lectin extracted from stinging nettle rhizomes, inhibited severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) cell to cell fusion.

12 Jul 2022

DNA must be enormously compressed in sperm cells, study says

If you are moaning once again about your suitcase being far too small as your vacation approaches, you should take human sperm cells as an inspiration.

11 Jul 2022

Revolutionary technology identifies molecular alterations in failing hearts at single-cell resolution

Imagine, if scientists had a map of the heart, so granular in its accuracy that it even profiled details of the heart at the cellular level.

8 Jul 2022

Scientists uncover how the innate immune system detects and fights HIV-1

Human immunodeficiency virus 1, more commonly known as HIV-1, is known for its uncanny ability to evade the immune system.

8 Jul 2022

Researchers develop a modular software system for optimizing biological systems

Machine learning is transforming all areas of biological science and industry, but is typically limited to a few users and scenarios.

8 Jul 2022

Study offers a new understanding of the evolutionary diversification of KNL2 gene

In living organisms cells divide and reproduce in two ways, mitosis and meiosis. Mitosis results in two identical daughter cells, whereas meiosis results in four sex cells.

8 Jul 2022

Study finds microglia to be responsible for neuronal death in a mitochondrial disease animal model

Microglia, a type of central nervous system cell, is primarily responsible for neuronal death in Leigh Syndrome and the neurological symptoms related to this mitochondrial disease.

8 Jul 2022

Nanoparticle vaccine could protect against animal viruses including future SARS-CoV-2 variants

A recent study published in the Science journal depicted that mosaic receptor-binding domain (RBD) nanoparticles immunize from diverse sarbecovirus challenges, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), among animal models.

8 Jul 2022

Discovery of multiple new SARS-CoV-2 MPro inhibitors

In a recent study posted to the bioRxiv* preprint server, researchers performed an extensive library docking for new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro) covalent and non-covalent inhibitors.

8 Jul 2022

Molecular & Structural Biology

Pox viruses deliver proteins that directly interfere with the body's innate immune system

Brain encodes the structure of sentences and phrases into different neural firing patterns, study finds

New transport system exemplifies the potential of a de novo design of peptides and proteins

Study discovers the most complex knotted protein to date

SARS-Arena reveals conserved parts of viral proteins that cause COVID-19

Prion imaging could lead to better understanding of what causes fatal neurological disorders

Study identifies a protein that plays key role in protecting the gastrointestinal tract from inflammation

Study reveals a specific metabolic adaptation in some patients with acute myeloid leukemia

New regulatory code of protein glycosylation

Researchers gain unexpected insights into activation mechanism of flaviviruses

Ancestral molecule from bacteria-like cells may offer evolutionary insight on sexual reproduction

Stinging nettle extract inhibits SARS-CoV-2 cell fusion

DNA must be enormously compressed in sperm cells, study says

Revolutionary technology identifies molecular alterations in failing hearts at single-cell resolution

Scientists uncover how the innate immune system detects and fights HIV-1

Researchers develop a modular software system for optimizing biological systems

Study offers a new understanding of the evolutionary diversification of KNL2 gene

Study finds microglia to be responsible for neuronal death in a mitochondrial disease animal model

Nanoparticle vaccine could protect against animal viruses including future SARS-CoV-2 variants

Discovery of multiple new SARS-CoV-2 MPro inhibitors

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