Molecular & Structural Biology

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Recent advances in non-viral nano-vector delivery of CRISPR/Cas9 genome editing payloads

Researchers reviewed non-viral nano-vectors used for delivering the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9-mediated genome editing system.

14 Apr 2022

Structural differences between SARS-CoV-1 and SARS-CoV-2 RBDs

A new study compares the SARS-CoV-2 RBD to the SARS-CoV RBD using computational methods to understand their binding affinities to ACE2.

13 Apr 2022

Social connections predict the brain structure of primates

What's the link between social life and brain structure? Researchers from the University of Pennsylvania, the Stem Cell and Brain Research Institute at Inserm, and elsewhere are now one step closer to understanding this connection for rhesus macaques.

13 Apr 2022

The molecular context and substrate profiles of human cell surface receptor tyrosine kinases

researchers discussed and identified the systemic functions and interactions of 52 active cell surface receptor tyrosine kinases, providing insights on RTK-RTK interactions and substrates, RTK-protein complexes, and signaling pathways.

13 Apr 2022

Treg cell Notch receptors drive SARS-CoV-2-induced MIS-C

In a recent study under consideration at Nature Portfolio Journal and posted to the Research Square* preprint server, researchers demonstrated the evolution of multi-system inflammatory syndrome in children (MIS-C) following acute severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

12 Apr 2022

Development of 18 monoclonal antibodies against 9 SARS-CoV-2 proteins

A new study aimed to generate, characterize, and optimize Abs against SARS-CoV-2 proteins.

12 Apr 2022

Experimental tool can precisely pick out interactions between immune cell and target antigen

The human body has millions of unique B and T cells that roam the body, looking for microbial invaders. These immune cells' ability to recognize harmful microbes is critical to successfully fighting off infection.

12 Apr 2022

Evidence of an increased risk of neurodegeneration after SARS-CoV-2 infection

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11 Apr 2022

Advanced microscopy reveals exciting insights into dynamic ultrastructure of the heart

What happens below the cellular level when the heart contracts and relaxes has long been unexplored. Thanks to new ultra-high-resolution electron microscopy techniques, scientists can now watch the heart beating – almost at a molecular level.

8 Apr 2022

Researchers discover new mechanisms for bone loss in gum disease

Tokyo University of Agriculture and Technology researchers reported on a new discovery regarding the mechanisms for bone loss in gum disease (periodontitis). They found that double stranded RNA molecules can activate the immune system response that leads to deterioration of bone.

8 Apr 2022

SARS-CoV-2 mutations capable of widespread T-cell escape

A new study aimed to identify and screen the mutations observed in SARS-CoV-2 that help to facilitate CD8+ T-cell escape.

7 Apr 2022

Cytoskeletal proteins work synergistically in the cell cortex to form intracellular networks

Investigators have discovered that two cytoskeletal proteins which were previously thought to function independently actually interact and form cytoskeletal networks within the cell surface, according to findings published in Proceedings of the National Academy of Sciences.

7 Apr 2022

Researchers design RNA molecules for delivering therapies directly to beta cells

Investigators at the University of Miami Miller School of Medicine have designed RNA molecules that home to human pancreatic beta cells, the cells that produce insulin and are destroyed in patients with type 1 and type 2 diabetes.

7 Apr 2022

New platform for studying how the immune system responds to hepatitis C

A vaccine for hepatitis C has eluded scientists for more than 30 years, for several reasons. For one, the virus that causes the disease comes in many genetic forms, complicating the creation of a widely effective vaccine.

6 Apr 2022

New insights on lung surfactants could lead to better treatments for respiratory illnesses

A team led by University of Minnesota Twin Cities engineering researchers analyzed the fundamental properties and structures of lung surfactant-;a naturally occurring substance that helps human and animal lungs expand and contract-;providing insight that could eventually help scientists develop better treatments for respiratory illnesses.

6 Apr 2022

UCI researchers reveal the impact of native lipids on rhodopsin signaling and regeneration

In a new study at University of California, Irvine, researchers have revealed the impact of native lipids on rhodopsin signaling and regeneration, which may usher in a new paradigm for discovery of drugs that target G protein-coupled receptors (GPCRs).

6 Apr 2022

Molecular & Structural Biology

Recent advances in non-viral nano-vector delivery of CRISPR/Cas9 genome editing payloads

Structural differences between SARS-CoV-1 and SARS-CoV-2 RBDs

Social connections predict the brain structure of primates

The molecular context and substrate profiles of human cell surface receptor tyrosine kinases

Treg cell Notch receptors drive SARS-CoV-2-induced MIS-C

Development of 18 monoclonal antibodies against 9 SARS-CoV-2 proteins

Experimental tool can precisely pick out interactions between immune cell and target antigen

Evidence of an increased risk of neurodegeneration after SARS-CoV-2 infection

Advanced microscopy reveals exciting insights into dynamic ultrastructure of the heart

Researchers discover new mechanisms for bone loss in gum disease

SARS-CoV-2 mutations capable of widespread T-cell escape

Cytoskeletal proteins work synergistically in the cell cortex to form intracellular networks

Researchers design RNA molecules for delivering therapies directly to beta cells

New platform for studying how the immune system responds to hepatitis C

New insights on lung surfactants could lead to better treatments for respiratory illnesses

UCI researchers reveal the impact of native lipids on rhodopsin signaling and regeneration

Cryo-EM imaging of a key immune protein reveals previously unrecognized binding site

Phenotypic changes in monocytes from COVID-19 patients

SARS-CoV-2 ORF8 interferes with antibody-dependent cellular cytotoxicity

Study reveals how pancreatic tumors program macrophages to construct fibrotic barriers

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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