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Acrylamide-based novel DHODH inhibitors as potential treatment for rheumatoid arthritis

Human dihydroorotate dehydrogenase (DHODH) is a viable target for the development of therapeutics to treat cancer and immunological diseases, such as rheumatoid arthritis (RA), psoriasis and multiple sclerosis (MS).

8 Apr 2021

Researchers develop innovative tough gel sheathed sutures inspired by human tendons

Sutures are used to close wounds and speed up the natural healing process, but they can also complicate matters by causing damage to soft tissues with their stiff fibers. To remedy the problem, researchers from Montreal have developed innovative tough gel sheathed (TGS) sutures inspired by the human tendon.

8 Apr 2021

Researchers address the issue of drug shortages

The two researchers are among the first to address the issue of drug shortages in contexts outside of the US; their study will look at the supply of medicines in Europe, with a focus on Germany, Austria and Switzerland.

7 Apr 2021

Antifungal and antidepressant drugs can effectively inhibit COVID-19 virus

New research published in the British Journal of Pharmacology indicates that two currently available medications--an antifungal drug and an antidepressant--can effectively inhibit the virus that causes COVID-19 in laboratory cells.

7 Apr 2021

Study lists five facts to know about antihistamines

If you are one of the millions of people worldwide suffering from allergies, you may take an antihistamine pill to ward off hives, sneezing and watery eyes.

6 Apr 2021

Early treatment with anti-VEGF injections slows diabetic retinopathy

Early treatment with anti-VEGF injections slowed diabetic retinopathy in a clinical study from the DRCR Retina Network (DRCR.net). However, two years into the four-year study its effect on vision was similar to standard treatment, which usually begins at the onset of late disease.

31 Mar 2021

Widely available drug reduces morbidity, mortality in COVID-19-infected mice

Mount Sinai researchers have found that a widely available and inexpensive drug targeting inflammatory genes has reduced morbidity and mortality in mice infected with SARS-CoV-2, the virus that causes COVID-19.

31 Mar 2021

NIAID researchers identify key player in the immune response to SARS-CoV-2

When variants of SARS-CoV-2 (the virus that causes COVID-19) emerged in late 2020, concern arose that they might elude protective immune responses generated by prior infection or vaccination, potentially making re-infection more likely or vaccination less effective.

31 Mar 2021

Study finds remarkable differences in the way individuals respond to malaria

Scientists have discovered that tracking malaria as it develops in humans is a powerful way to detect how the malaria parasite causes a range of infection outcomes in its host.

31 Mar 2021

Combination of two existing drugs can kill cancer cells

Preclinical research from VCU Massey Cancer Center published recently in the Proceedings of the National Academy of Sciences shows that the combination of two existing drugs can exploit the metabolic "hunger" of a particularly aggressive type of neuroblastoma to kill cancer cells without inflicting too much collateral damage to healthy tissue.

31 Mar 2021

Study highlights the importance of benzothiazole in TB treatment regimens

Tuberculosis is a serious infectious disease, which is caused by the Mycobacterium tuberculosis, generally it affects the lungs. Tuberculosis is spread from one person to another through microscopic droplets released into the air, it can happen through coughs, speaks, sneezes, spits, laughs from the active tuberculosis patient

30 Mar 2021

Study: Common medications are often derived from animal byproducts

More physicians and pharmacists are advocating for patients to be made aware of animal byproducts contained in common medications, according to new research in the Journal of Osteopathic Medicine.

29 Mar 2021

Pfizer-BioNTech vaccine causes steep drop in COVID-19 among healthcare workers

A team of scientists from Spain has recently evaluated the efficacy of an mRNA-based COVID-19 vaccine developed by Pfizer-BioNTech (BNT162b2). Their findings reveal that a 2-dose regimen of BNT162b2 vaccine is capable of providing almost 100% protection against SARS-CoV-2 infection in healthcare workers.

29 Mar 2021

Researchers explore a case of diabetic ketoacidosis in patient with atezolizumab-induced autoimmune diabetes

In a new publication from Cardiovascular Innovations and Applications, Sharen Lee and Gary Tse from Laboratory of Cardiovascular Physiology, Hong Kong, HKG, China, Second Hospital of Tianjin Medical University, Tianjin, China and Xiamen Cardiovascular Hospital, Xiamen, China consider a case of atezolizumab-induced autoimmune diabetes mellitus presenting with diabetic ketoacidosis.

29 Mar 2021

Scientists seek Covid treatment answers in cheap, older drugs

Could a decades-old antidepressant be a secret weapon against covid? A few scientists think so, after two small studies showed that fluvoxamine, typically prescribed for obsessive-compulsive disorder, prevented serious illness in all participants who took the pills soon after developing symptoms.

29 Mar 2021

FDA acknowledged receipt of ORNL’s cancer-fighting Ac-225 isotope

A rare isotope in high demand for treating cancer is now more available to pharmaceutical companies developing and testing new drugs.

27 Mar 2021

One dose of Pfizer vaccine generates strong immune response against COVID-19

A new study led by the Universities of Sheffield and Oxford with support from the UK Coronavirus Immunology Consortium (UK-CIC) has found that 99 per cent of people generate a robust immune response against Covid-19 after just one dose of the Pfizer vaccine.

26 Mar 2021

Naloxone can save lives but stigma is preventing its use among newly abstinent opioid users

Opioids are the main driver of fatal drug overdoses in the United States, according to the Centers for Disease Control and Prevention, resulting in 46,802 deaths in 2018, usually because the person stops breathing.

26 Mar 2021

Genomic sieve analysis can inform the development of SARS-Cov-2 vaccine

As concern has grown over COVID-19 variants and their implications for how well COVID-19 vaccines will protect against the virus, researchers have proposed a method to examine instances of SARS-COV-2 infections in people who have received a COVID-19 vaccine.

26 Mar 2021