Cytokines News and Research

Latest Cytokines News and Research

Study reveals the role of lncRNAs in immune dysfunction during severe COVID-19

Scientific studies rarely focus on long non-coding RNA molecules (lncRNAs), even though they potentially regulate several diseases. The role of several lncRNAs in anti-viral inflammatory response regulation has recently been reported.

28 Apr 2021

Recombinant protein vaccine fails expectations for SARS-CoV-2 neutralization

New interim results of a phase 1-2 clinical trial published in The Lancet Infectious Diseases tested the safety and effectiveness of an adjuvanted recombinant protein vaccine against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) called CoV2 preS dTM.

26 Apr 2021

DNA vaccine candidate induces potent immunity, offers protective efficacy in non-human primate models

A synthetic DNA vaccine candidate for Middle East respiratory syndrome coronavirus (MERS-CoV) developed at The Wistar Institute induced potent immune responses and afforded protective efficacy in non-human primate (NHP) models when given intradermally in abbreviated, low-dose immunization regimen.

23 Apr 2021

Celastrol shows potential anti-SARS-CoV-2 activity

A new study published on the bioRxiv* preprint server focuses on the in-silico predictions to repurpose existing drug compounds, that may have the ability to reverse the SARS-CoV-2 gene expression induced in host cells.

23 Apr 2021

Some COX inhibitors/NSAIDs increase COVID-19 severity

A startling new preprint research paper posted to the medRxiv server warns against the use of commonly used non-steroidal anti-inflammatory drugs (NSAIDs) belonging to the category of cyclooxygenase inhibitors (COX inhibitors) in patients with coronavirus disease 2019 (COVID-19).

22 Apr 2021

Pro-inflammatory diet may be associated with increased risk of testosterone deficiency in men

Consuming a diet high in pro-inflammatory foods - including foods that contain refined carbohydrates and sugar as well as polyunsaturated fats - may be associated with increased odds of developing testosterone deficiency among men, suggests a study in The Journal of Urology, Official Journal of the American Urological Association.

21 Apr 2021

SARS-CoV-2-associated ssRNAs trigger inflammation and immunity via toll-like receptors

Severe COVID-19 causes sepsis-like manifestations, intense lung injury, and multi-organ failure, all associated with the overproduction of pro-inflammatory cytokines. This "cytokine storm" directly correlates with poor prognosis in this subgroup of patients.

21 Apr 2021

SARS-CoV-2 does not directly infect the brain but can inflict neurological damage

SARS-CoV-2, the virus that causes COVID-19, likely does not directly infect the brain but can still inflict significant neurological damage, according to a new study from neuropathologists, neurologists, and neuroradiologists at Columbia University Vagelos College of Physicians and Surgeons.

17 Apr 2021

Researchers identify two distinct phenotypes of COVID-19-associated ARDS

Approximately one in four patients hospitalized for the acute respiratory distress syndrome (ARDS) associated with severe COVID-19 infections may have a distinct phenotype (disease presentation) or biochemical profile associated with organ dysfunction, blood-clotting abnormalities and greater risk of death than patients with other, seemingly similar forms of the disease, researchers at Massachusetts General Hospital have found.

15 Apr 2021

Can biomaterials offer novel therapeutic strategies against COVID-19?

A team of scientists reviews the current and potential impact of the biomaterial sciences on the COVID-19 pandemic.

15 Apr 2021

High antibody and inflammatory mediator levels may predict severe COVID-19

A new study reports on biomarkers could help predict the progression of the viral illness to dangerous levels early enough to enable timely intervention.

15 Apr 2021

Self-assembling nanofibers can help limit damage caused by inflammatory diseases

Biomedical engineers at Duke University have developed a self-assembling nanomaterial that can help limit damage caused by inflammatory diseases by activating key cells in the immune system.

15 Apr 2021

Series of reviews discuss key issues in chronic kidney disease and bone disorders

Metabolic bone disease is a common complication of chronic kidney disease (CKD) and involves a broad spectrum of disorders of mineral metabolism that result in both skeletal and extra-skeletal consequences.

15 Apr 2021

Study identifies differences in biomarkers of inflammation between novel diabetes subgroups

Chronic inflammation is increasingly a focus of research. A recent study has now identified differences in indicators of inflammation between novel diabetes subgroups. But what does this mean for the future?

15 Apr 2021

Ponatinib identified as a potent inhibitor of SARS-CoV2-induced cytokine storm

Researchers at the Human Biology Division, Fred Hutchinson Cancer Research Center in Washington, United States, found that the FDA-approved, multi-kinase inhibitor Ponatinib is a potent inhibitor of the N-terminal domain (NTD) -mediated cytokine storm. Ponatinib is an oral drug used for the treatment of chronic myeloid leukemia (CML).

14 Apr 2021

Researchers investigate link between COVID-19 and increased risk of blood clot formation

People who have recovered from COVID-19, especially those with pre-existing cardiovascular conditions, may be at risk of developing blood clots due to a lingering and overactive immune response, according to a study led by Nanyang Technological University, Singapore (NTU) scientists.

13 Apr 2021

Clinical trial of monoclonal antibody for treating respiratory disease in COVID-19 patients begins

A clinical trial testing the safety and efficacy of an investigational monoclonal antibody for treating people who are hospitalized with respiratory disease and low blood oxygen due to infection with SARS-CoV-2, the virus that causes COVID-19, has begun.

13 Apr 2021

Cytokines News and Research

Latest Cytokines News and Research

Study reveals the role of lncRNAs in immune dysfunction during severe COVID-19

Recombinant protein vaccine fails expectations for SARS-CoV-2 neutralization

DNA vaccine candidate induces potent immunity, offers protective efficacy in non-human primate models

Celastrol shows potential anti-SARS-CoV-2 activity

Some COX inhibitors/NSAIDs increase COVID-19 severity

Pro-inflammatory diet may be associated with increased risk of testosterone deficiency in men

SARS-CoV-2-associated ssRNAs trigger inflammation and immunity via toll-like receptors

SARS-CoV-2 does not directly infect the brain but can inflict neurological damage

Researchers identify two distinct phenotypes of COVID-19-associated ARDS

Can biomaterials offer novel therapeutic strategies against COVID-19?

High antibody and inflammatory mediator levels may predict severe COVID-19

Self-assembling nanofibers can help limit damage caused by inflammatory diseases

Series of reviews discuss key issues in chronic kidney disease and bone disorders

Study identifies differences in biomarkers of inflammation between novel diabetes subgroups

Ponatinib identified as a potent inhibitor of SARS-CoV2-induced cytokine storm

Researchers investigate link between COVID-19 and increased risk of blood clot formation

Clinical trial of monoclonal antibody for treating respiratory disease in COVID-19 patients begins

Which SARS-CoV-2 spike mutants can evade T cell immunity?

SARS-CoV-2 inhibits the cellular response to interferon

Widely available drug reduces morbidity, mortality in COVID-19-infected mice

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

Cytokines News and Research

Latest Cytokines News and Research

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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