T Cell News and Research

Latest T Cell News and Research

Study provides a more effective treatment approach to preventing graft-versus-host-disease

A new study led by UC Davis Health researchers showed that blocking IL-6 and TNF cytokines provides a more effective approach to preventing life-threatening graft-versus-host-disease (GVHD), an inflammatory condition that develops in patients after their allogeneic hematopoietic stem cell transplantation (allo-HSCT).

16 Dec 2021

Researchers map how the HTLV-1 virus causes a rare leukemia in some people

An international team have mapped how the HTLV-1 virus causes a rare leukemia in some people, providing clues on how to stop it happening.

16 Dec 2021

Scientists find better treatment options for patients with advanced colorectal cancer

City of Hope, a world-renowned cancer research and treatment organization, today announced study results of a Phase 2 clinical trial showing monotherapy with sotorasib resulted in anti-tumor activity and a favorable benefit-risk profile among heavily pretreated patients with advanced colorectal cancer. The research was published today in Lancet Oncology.

16 Dec 2021

Weak T-cell clonal response to SARS-CoV-2 vaccination in IBD patients deficient in antibody-responders

Researchers investigate the post-vaccination clonal T-cell response and its relationship to antibody responses in IBD patients.

15 Dec 2021

T-cell immune response in previously infected and vaccinated individuals effective against SARS-CoV-2 Omicron variant

New findings illustrate that despite the continuous pattern of the ongoing evolution of SARS-CoV-2, it has not resulted in any significant accumulation of CD8+ T-cell escape mutations.

15 Dec 2021

Cell surface expression of SARS-CoV-2 nucleocapsid protein and its role in immunity

Researchers demonstrated the unexpected roles of nucleocapsid protein in innate and adaptive immunity to SARS-CoV-2.

15 Dec 2021

Study reveals molecular players involved in the onset of leukemia

A new study led by João T. Barata from Instituto de Medicina Molecular João Lobo Antunes (iMM, Portugal), and J. Andrés Yunes from Centro Infantil Boldrini (Brazil), published now in the scientific journal Nature Communications, shows that changes in a protein called IL-7R are sufficient to initiate a type of leukemia.

14 Dec 2021

Researchers uncover a key role for SIRT1 enzyme in T-cell acute lymphoblastic leukemia

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive type of leukemia. Despite advances in treatments, patients have an extremely poor prognosis, highlighting the need to explore the genetic components that lead to the formation of T-ALL, as well as the need to discover new targeted therapeutic approaches and treatment resistance.

14 Dec 2021

New mRNA vaccine platform provides stronger protection against SARS-CoV-2 delta variant

A group of researchers from various institutions developed a nucleoside-modified mRNA vaccine that encodes the SARS-CoV-2 N protein (mRNA-N) and is formulated in lipid nanoparticles for this investigation (LNP).

14 Dec 2021

Lymphoma patients can benefit from early CAR T treatment, study shows

Chimeric antigen receptor T-cell therapy or CAR T is a breakthrough treatment for patients with certain types of blood cancers.

13 Dec 2021

$Study finds new treatment option for patients with relapsed or refractory peripheral T-cell lymphoma$

Study finds new treatment option for patients with relapsed or refractory peripheral T-cell lymphoma

The final results from a national phase 2 study including researchers from Yale Cancer Center show the drug tipifarnib increased survival rates for patients with relapsed or refractory peripheral T-cell lymphoma (PTCL).

13 Dec 2021

Study offers new hope for large B-cell lymphoma patients

Of the 18,000 people diagnosed with large B-cell lymphoma each year, only half will be successfully treated with chemotherapy. The 9,000 remaining patients typically have poor outcomes, with only 25% responding to additional, higher-intensity chemotherapy, followed by a stem cell transplant.

13 Dec 2021

Drug combination without chemotherapy can be effective in treating older patients with Ph+ ALL

The combination of dasatinib, blinatumomab, and prednisone can be effective in treating older patients with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) who are not good candidates for intensive chemotherapy treatment.

13 Dec 2021

Bioinformatics pipeline can be used to quickly identify SARS-CoV-2 therapeutics

In a new study, researchers developed a bioinformatics pipeline that uses RNA sequencing data to identify altered genes and signaling pathways affected by viral infection.

13 Dec 2021

SARS-CoV-2-specific T cell and antibody responses in healthcare workers that suffered from COVID-19 one year ago

Researchers have been investigating the immune response in previously infected healthcare workers after they receive these vaccines.

13 Dec 2021

Even if SARS-CoV-2 Omicron evades antibodies, immunity still exists

Researchers determined antibody-mediated neutralization efficacy against the authentic SARS-CoV-2 Omicron variant.

12 Dec 2021

Investigational mRNA-based HIV vaccine shows promise in mice and non-human primates

An experimental HIV vaccine based on mRNA—the same platform technology used in two highly effective COVID-19 vaccines—shows promise in mice and non-human primates, according to scientists at the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health.

9 Dec 2021

Effect of SARS-CoV-2 variant emergence on efficacy of neutralizing antibodies and vaccines

A review article focuses on the efficacy of neutralizing antibodies and vaccines against the SARS-CoV-2 variants.

9 Dec 2021

Exploring SARS-CoV-2 vaccine responsiveness in immunosuppressed patients

A new study indicates an immunological response to SARS-CoV-2 vaccines in immunosuppressed patients that were comparable to healthy patients.

7 Dec 2021

COVID-19 severity is correlated with T cell receptor repertoire signatures

In a new study published in the bioRxiv* preprint server, researchers found that specific TCR sequences predicted the severity of coronavirus disease 2019 (COVID-19) infection. Additionally, there was evidence of increased CDR3 sequences and changes in k-mer motifs for patients with severe illness.

6 Dec 2021

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T Cell News and Research

Latest T Cell News and Research

Study provides a more effective treatment approach to preventing graft-versus-host-disease

Researchers map how the HTLV-1 virus causes a rare leukemia in some people

Scientists find better treatment options for patients with advanced colorectal cancer

Weak T-cell clonal response to SARS-CoV-2 vaccination in IBD patients deficient in antibody-responders

T-cell immune response in previously infected and vaccinated individuals effective against SARS-CoV-2 Omicron variant

Cell surface expression of SARS-CoV-2 nucleocapsid protein and its role in immunity

Study reveals molecular players involved in the onset of leukemia

Researchers uncover a key role for SIRT1 enzyme in T-cell acute lymphoblastic leukemia

New mRNA vaccine platform provides stronger protection against SARS-CoV-2 delta variant

Lymphoma patients can benefit from early CAR T treatment, study shows

Study finds new treatment option for patients with relapsed or refractory peripheral T-cell lymphoma

Study offers new hope for large B-cell lymphoma patients

Drug combination without chemotherapy can be effective in treating older patients with Ph+ ALL

Bioinformatics pipeline can be used to quickly identify SARS-CoV-2 therapeutics

SARS-CoV-2-specific T cell and antibody responses in healthcare workers that suffered from COVID-19 one year ago

Even if SARS-CoV-2 Omicron evades antibodies, immunity still exists

Investigational mRNA-based HIV vaccine shows promise in mice and non-human primates

Effect of SARS-CoV-2 variant emergence on efficacy of neutralizing antibodies and vaccines

Exploring SARS-CoV-2 vaccine responsiveness in immunosuppressed patients

COVID-19 severity is correlated with T cell receptor repertoire signatures

Immunology eBook

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

T Cell News and Research

Latest T Cell News and Research

Immunology eBook

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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