New model explains how the brain restores walking rhythm after disruptions

Osaka UniversitySep 20 2024

Walking is an activity that is often taken for granted. Most people usually think they can multitask by "walking and chewing gum" simultaneously with hardly any taxation of their mental effort. Indeed, each leg can move rhythmically independently of the other, controlled by its side of the spinal cord. However, the ability of the human brain to coordinate the gait so that a walker's legs are half a stride out of phase with each other, called the "antiphase relationship," is not so trivial when an obstacle or asymmetry occurs, such as a curve in the path. A better understanding of how a normal walking cadence is maintained may lead to enhanced rehabilitation techniques for patients who have experienced brain trauma or other neurological problems.

In a study recently published in Communications Biology, researchers from Osaka University captured kinematic data from healthy patients walking on a treadmill that was occasionally perturbed by a sudden change in speed. This led to a momentary loss of the antiphase relationship, but it was quickly restored as the subjects reoriented their walking movements. The data from this experiment was analyzed using a mathematical model of two coupled oscillators – similar to two pendulums connected by a spring – along with a Bayesian inference method. The approach allowed the researchers to calculate the most probable function that represents how the brain applied its control to coordinate the leg motions.

To simplify the problem further, phase reduction theory was applied, which assumes that the perturbed system is returning to a regular periodic solution, called the limit cycle.

Using Bayesian inference enabled us to infer the control of leg coordination in a quantitative way."

Takahiro Arai, lead author of the study

Surprisingly, the researchers found that the relative phase is not actively controlled by the brain until the deviation from correct the antiphase orientation exceeds a certain threshold. That is, the brain does not actively intervene to coordinate the relative position of the legs until they are a certain amount out of lockstep. They suggest that not requiring the constant application of control improves both energy efficiency and maneuverability.

"Based on our model, we see that the brain is neither overly controlling, which would limit our ability to negotiate obstacles and also consume a lot of brainpower, nor overly lax, which could lead to falling over when the legs become too uncoordinated," says senior author, Shinya Aoi.

This research may be important to help improve the walking of elderly people, or individuals who have experienced the neurological effects of a stroke or Parkinson's disease. It may also lead to the development of physical aids that help people walk more naturally.