This neuronal protein plays multiple roles in synaptic activity, including regulating synaptic vesicle trafficking and neurotransmitter release. As a monomer, it enhances synaptic vesicle exocytosis by promoting vesicle priming, fusion, and the dilation of exocytotic fusion pores.
Synuclein alpha increases local Ca2+ release from microdomains, which is crucial for the enhancement of ATP-induced exocytosis.
In its multimeric membrane-bound state, the protein acts as a molecular chaperone, assisting in the folding of synaptic fusion components known as SNAREs (Soluble NSF Attachment Protein REceptors) at the presynaptic plasma membrane, in conjunction with cysteine string protein-alpha (DNAJC5). This chaperone activity is vital for maintaining normal SNARE-complex assembly during aging. Additionally, the protein regulates dopamine neurotransmission by associating with the dopamine transporter (DAT1) and modulating its activity.
Brief information
- Name: Synuclein alpha
- Target Synonym: Truncated Alpha Synuclein, Α-Synuclein, Non-A Beta Component Of AD Amyloid, Synuclein Alpha-140, I+/--Synuclein, α-Synuclein, PARK4, PD1, alpha-Synuclein, Synuclein, Alpha (Non A4 Component Of Amyloid Precursor), Non A-Beta Component Of AD Amyloid, PARK1, SNCA, Synuclein Alpha, NACP, Parkinson Disease (Autosomal Dominant, Lewy Body) 4, Non-A4 Component Of Amyloid Precursor, Non A4 Component Of Amyloid Precursor
- Number of Launched Drugs: 0
- Number of Drugs in Clinical Trials: 20
- Latest Research Phase: Phase 3 Clinical
Part of bioactivity data
CHEK-ATP085-cell-based assay
Image Credit: ACROBiosystems
- FACS study of Alpha-synuclein (GFP) in the HEK293/Human Alpha-synuclein (GFP) Cell Line
- The HEK293/Human Alpha-synuclein (GFP) Stable Cell Line was shown in red, whereas the negative control HEK293 cells were shown in grey line (QC tested)
ALN-H51H5-ELISA
Immobilized Human Alpha-Synuclein (A53T), His Tag (Cat. No. ALN-H51H5) at 1 μg/mL (100 μL/well) can bind Synuclein alpha/beta Monoclonal Antibody with a linear range of 1-31 ng/mL (QC tested). Image Credit: ACROBiosystems
ALN-H5117-MALS-HPLC
The purity of Human Alpha-Synuclein (E46K), Tag Free (Cat. No. ALN-H5117) is more than 95% and the molecular weight of this protein is around 13-20 kDa verified by SEC-MALS. Image Credit: ACROBiosystems
Synonym name
- SNCA, NACP, PARK1, alpha-synuclein