Neural factors for nerve cell regeneration

Neural factors are a class of protein molecules with neurotrophic activity that promote the survival and regeneration of nerve cells. Increasingly, these factors are recognized for their neuroprotective roles in conditions such as stroke and brain injury. When peripheral nerves are injured, protecting neurons from apoptosis is essential for nerve regeneration. Exogenous neural factors can support the survival of various types of neurons, aiding in recovery and repair.

Recent studies indicate that the combined effect of multiple neural factors in repairing peripheral nerve injury surpasses that of a single factor. Nerve injury alters the levels of various peripheral neurotrophic factors and their receptors, which collectively participate in nerve repair. Therefore, the combined action of these neural factors more accurately reflects the body's natural state and enhances the protective effect on neurons.

Typical neural factors and functions

Neurotrophic factors (NTFs) are a group of typical neural factors that include nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophic factor-3 (NT-3), neurotrophin-4 (NT-4, NT-5), neurotrophin-6 (NT-6), ciliary neurotrophic factor (CNTF), glia cell line-derived neurotrophic factor (GDNF), and others.

• NGF is a protein that promotes the growth, development, differentiation, and fast maturation of central and peripheral neurons. As the first and most extensively researched neurotrophic factor, it regulates the development, differentiation, growth, regeneration, and expression of functional qualities in central and peripheral neurons. NGF has three subunits: α, β, and γ, with the active region being the β subunit.
• NT-3 can help neural stem cells survive, stimulate their proliferation and differentiation, and protect sensory and sympathetic neurons in the peripheral nervous system, as well as motor neurons in the central nervous system.
• NT-4 is the fourth member of the neuron factor family, and it promotes neuronal growth, development, differentiation, and maturation. It can help neurons survive, heal, and regenerate after injury, influence neuro-immunity-endocrine interactions, control synaptic plasticity, enhance neuromuscular junction development, and trigger collateral sprouting in normal motor neurons.
• GDNF is a neural factor that has distinct neurotrophic characteristics. It can enhance the survival of diverse neuronal subsets in the central and peripheral nervous systems at various stages of development, as well as the survival of midbrain dopaminergic neurons in vitro. Furthermore, GDNF has been validated in animal models of Parkinson’s disease to improve conditions such as bradykinesia, stiffness, and postural instability.
• Midkine (MDK), also known as neurite outgrowth promoting factor-2, is a heparin-binding growth factor identified in 1988. It regulates cell proliferation, migration, angiogenesis, and fibrinolysis.

Product list

Aneuro, the ACROBiosystems brand that focuses on neuroscience, has produced a series of recombinant neural factors that promote nerve cell growth and differentiation.

Source: ACROBiosystems