Tau is a microtubule-associated protein encoded by the MAPT gene located on chromosome 17q21. It promotes microtubule assembly and stability and may play a role in establishing and maintaining neuronal polarity.
Hyperphosphorylation of tau (resulting in tau inclusions, or pTau) can lead to the self-assembly of tangles of paired helical filaments and straight filaments, contributing to the pathogenesis of Alzheimer's disease, frontotemporal dementia, and other tauopathies.
Brief information
- Name: Microtubule-associated protein tau
- Target Synonym: MAPT, MTBT1, Paired helical filament-tau, MAPTL, Microtubule Associated Protein Tau, G Protein Beta1/Gamma2 Subunit-Interacting Factor 1, Protein Phosphatase 1, Regulatory Subunit 103, Neurofibrillary Tangle Protein, PHF-Tau,TAU, Microtubule-Associated Protein Tau, Isoform 4, Microtubule-Associated Protein Tau, PPP1R103, FTDP-17, MTBT2, DDPAC, MSTD, PPND, tau Proteins, MGC138549, FLJ31424
- Number of Launched Drugs: 1
- Number of Drugs in Clinical Trials: 34
- Lastest Research Phase: Approved
Part of bioactivity data
Image Credit: ACROBiosystems
- FACS study of Tau-K18 (GFP) in the stable cell line HEK293/Human Tau-K18 (GFP)
- The HEK293/Human Tau-K18 (GFP) Stable Cell Line was shown in red, whereas the negative control HEK293 cells were shown in grey line (QC tested)
Immobilized Human Tau-441 GSK-3beta-phosphorylated protein, His Tag (Cat. No. TAU-H5147) at 1 μg/mL (100 μL/well) can bind Anti-Phospho-Tau (Thr181) Monoclonal Antibody, Mouse IgG with a linear range of 1-31 ng/mL (QC tested). Image Credit: ACROBiosystems
The purity of Human Tau-441 (K18, P301L) Protein, Tag Free (Cat. No. TAU-H5118) is more than 85% and the molecular weight of this protein is around 12-18 kDa verified by SEC-MALS. Image Credit: ACROBiosystems
Synonym name
- DDPAC, FTDP-17, MAPT, MSTD, MTBT1, Tau, PHF-tau, TAU