Sortilin functions as both a sorting receptor in the Golgi compartment and a clearance receptor on the cell surface. It is essential for protein transport from the Golgi apparatus to the lysosomes via a pathway independent of the mannose-6-phosphate receptor (M6PR).
Lysosomal proteins specifically bind to Sortilin in the Golgi apparatus, forming a receptor-ligand complex that is transported to an acidic prelysosomal compartment. In this compartment, the low pH causes the dissociation of the complex, allowing the receptor to be recycled back to the Golgi through its interaction with the retromer complex for another round of trafficking.
Brief information
- Name: Sortilin
- Target Synonym: 100 kDa NT receptor, NT3, Glycoprotein 95, LDLCQ6, NTR3, Gp95, Sortilin 1, Neurotensin receptor 3
- Number of Launched Drugs: 0
- Number of Drugs in Clinical Trials: 2
- Latest Research Phase: Phase 3 Clinical
Part of bioactivity data
Biotinylated Human Sortilin Protein, His,Avitag (Cat. No. SON-H82E9) captured on Biotin CAP-Series S Sensor Chip can bind Human Progranulin Protein, His Tag (Cat. No. PGN-H52H3) with an affinity constant of 0.355 μM as determined in a SPR assay (Biacore 8K) (QC tested). Image Credit: ACROBiosystems Inc.
The purity of Biotinylated Human Sortilin Protein, His,Avitag (Cat. No. SON-H82E9) is more than 85% and the molecular weight of this protein is around 80-107 kDa verified by SEC-MALS. Image Credit: ACROBiosystems Inc.
Synonym name
Sortilin,SORT1,100 kDa NT receptor,Glycoprotein 95,Gp95,Gp95LDLCQ6,Neurotensin receptor 3,NT3NTR3,Ntr3, and sortilin 1.