APOE is an apolipoprotein that associates with lipid particles and primarily functions in lipoprotein-mediated lipid transport between organs via plasma and interstitial fluids. As a core component of plasma lipoproteins, APOE is involved in the production, conversion, and clearance of these lipoproteins.
Apolipoproteins are amphipathic molecules, meaning they interact with both the lipid core of lipoprotein particles and the aqueous environment of plasma. APOE associates with chylomicrons, chylomicron remnants, very low-density lipoproteins (VLDL), and intermediate-density lipoproteins (IDL), but it shows a preference for binding to high-density lipoproteins (HDL).
Additionally, APOE binds to a variety of cellular receptors, including the LDL receptor (LDLR), and LDL receptor-related proteins LRP1, LRP2, and LRP8, as well as the very low-density lipoprotein receptor (VLDLR), which mediate the cellular uptake of APOE-containing lipoprotein particles.
Brief information
- Name: Apolipoprotein E
- Target Synonym: APOE, Apolipoprotein E, Alzheimer Disease 2 (APOE*E4-Associated, Late Onset), Apolipoprotein E3, LDLCQ5, ApoE4, Apo-E, LPG, AD2, Apolipoproteins E
- Number of Launched Drugs: 0
- Number of Drugs in Clinical Trials: 2
- Lastest Research Phase: Phase 2 Clinical
Part of bioactivity data
APE-H5216-cell-based assay
3e5 of HeLa cells were co-incubated with 50 nM Cy3-labeled LNPs-siRNA in the presence or absence of 3 μg/mL Human Apolipoprotein E / APOE3 Protein, Tag Free (MALS verified) (ACRO Biosystems, Cat. No. APE-H5216), washed and analyzed with FACS. PE signal was used to evaluate the expression of Cy3+ HeLa cells (Routinely tested). Image Credit: ACROBiosystems
APE-H52E7-cell-based assay
3e5 of HeLa cells were co-incubated with 50 nM Cy3-labeled LNPs-siRNA in the presence or absence of 1 μg/mL Biotinylated Human APOE4, His,Avitag (Cat. No. APE-H52E7), washed and analyzed with FACS. PE signal was used to evaluate the expression of Cy3+ HeLa cells (Routinely tested). Image Credit: ACROBiosystems
APE-C52H7-SPR
Cynomolgus TREM2, His Tag (Cat. No. TR2-C52H3) immobilized on CM5 Chip can bind Cynomolgus Apolipoprotein E Protein, His Tag (Cat. No. APE-C52H7) with an affinity constant of 7.78 μM as determined in a SPR assay (Biacore 8K) (QC tested). Image Credit: ACROBiosystems
APE-C52H7-SPR
Cynomolgus Apolipoprotein E Protein, His Tag (Cat. No. APE-C52H7) immobilized on CM5 Chip can bind Cynomolgus TREM2, His Tag (Cat. No. TR2-C52H3) with an affinity constant of 4.54 μM as determined in a SPR assay (Biacore 8K) (Routinely tested). Image Credit: ACROBiosystems
Synonym name
- Apolipoprotein E, APOE, Apo-E