Amyloid precursor protein (APP) is a type I integral membrane protein ubiquitously expressed in many tissues and concentrated in the synapses of neurons. It has three predominant splice variants: APP695, APP751, and APP770.
The majority of APP is cleaved at the plasma membrane by the α-secretase in the non-amyloidogenic pathway. The amyloidogenic pathway starts with β-secretase cleavage by BACE1 on the N-terminal part of the Aβ domain, releasing sAPPβ from a membrane-anchored fragment named βCTF or C99, which is subsequently cleaved by γ-secretase to release Aβ.
Brief information
- Name: Beta amyloid A4 protein
- Target Synonym: Beta-CTF, Amyloid Beta Precursor Protein, Cerebral Vascular Amyloid Peptide, Beta-Amyloid Precursor Protein, Amyloid-Beta A4 Protein, Beta-Amyloid Peptide, Alzheimer Disease, CTFgamma, ABETA, AAA, PN2, Amyloid beta-Peptides, Amyloid intracellular domain 57, APP, Amyloid intracellular domain 59, PN-II, Alpha-secretase C-terminal fragment, AICD-50, S-APP-alpha, A4, S-APP-beta, Alzheimer disease amyloid protein, Abeta40, Gamma-CTF(59), Abeta42, Gamma-CTF(57), Alpha-CTF, Amyloid intracellular domain 50, AID(59), Gamma-CTF(50), A
- Number of Launched Drugs: 11
- Number of Drugs in Clinical Trials: 39
- Lastest Research Phase: Approved
Part of bioactivity data
Image Credit: ACROBiosystems Inc.
- FACS analysis of APP (GFP) on HEK293/Human APP (GFP) Stable Cell Line.
- HEK293/Human APP (GFP) Stable Cell Line was red line, negative control HEK293 cells was grey line (QC tested).
APP-H52H3-MALS-HPLC
Image Credit: ACROBiosystems Inc.
The purity of Human APP Protein, His Tag (Cat. No. APP-H52H3), exceeds 85 %, and its molecular weight, as verified by SEC-MALS, is approximately 80-110 kDa.
APP-H52H5-MALS-HPLC
The purity of Human SAPPbeta, His Tag (Cat. No. APP-H52H5), exceeds 90 %, and its molecular weight, as verified by SEC-MALS, is approximately 95-115 kDa.
Image Credit: ACROBiosystems Inc.
Synonym name
ABPP, APPI, Amyloid-beta A4 protein