Stem cells are a class of multipotential cells that can self-replicate, self-renew, and differentiate into multiple cell lines.
Stem cells provide a more realistic method of identifying and confirming new drug targets and generating pharmacology and toxicology data earlier, with stronger translation to the clinical setting. In addition, the application of stem cells in drug development creates a new path to personalized medicine, while at the same time reducing, or even replacing, animal testing.
Cytokines like Activin A/INHBA, EGF, OSM, VEGFA, LIF, IL3, and FGF2 play integral roles in stem and progenitor cell research. For instance, Activin A can be used to promote the differentiation of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) into endoderm.
OSM has often been used in conjunction with HGF, LIF, EGF, and FGF2 to discriminate mesenchymal stem cells (MSCs) into hepatocyte-like cells.
IL-3 promotes in-vitro migration of MSCs, highlighting its potential to enhance the efficacy of MSCs in regenerative cell therapy. EGF has illustrated the potential to improve the survival of definitive neural stem cells derived from the embryonic brain.
LIF is vital for controlling stem cell pluripotency, while FGF2 has been determined as a main regulator for several stem cell types.
Figure 1. Cytokine mapping in stem cell research. Image Credit: Sino Biological US Inc
Featured cytokines for stem cell research
- High-Purity
- Activity-Validated
- HPLC-Verified
- High Batch-to-Batch Consistency
High-purity: ≥ 95 % as determined by SDS-PAGE & SEC-HPLC. Image Credit: Sino Biological US Inc
Human vascular organoids derived from iPSCs were cultured using FGF2, VEGFA, and EGF. The vascular organoids are indicated by red arrows. Image Credit: Sino Biological US Inc
High batch-to-batch consistency: Cell proliferation assay using Balb/C 3T3 mouse embryonic fibroblasts. Image Credit: Sino Biological US Inc
High-purity: ≥ 95 % as determined by SDS-PAGE & SEC-HPLC. Image Credit: Sino Biological US Inc
Activity-validated: Cell proliferation assay using TF-1 human erythroleukemic cells. The specific activity is >30,000 Units/μg. Image Credit: Sino Biological US Inc
High batch-to-batch consistency: Cell proliferation assay using TF-1 human erythroleukemic cells. Image Credit: Sino Biological US Inc
High-purity: ≥ 95 % as determined by SDS-PAGE & SEC-HPLC. Image Credit: Sino Biological US Inc
Activity-validated: Cell proliferation assay using TF-1 human erythroleukemic cells. Image Credit: Sino Biological US Inc
High batch-to-batch consistency: Cell proliferation assay using TF-1 human erythroleukemic cells. Image Credit: Sino Biological US Inc
Other featured cytokines
Human FGF2 protein
(Cat#: GMP-10014-HNAE)
Activity-validated: Cell proliferation assay using Balb/c 3T3 mouse embryonic fibroblasts. The specific activity is >1,000 IU/μg. Image Credit: Sino Biological US Inc
Human Activin A protein
(Cat#: GMP-10429-HNAH)
Activity-validated: The inhibited proliferation of MPC-11 cells. The specific activity is >1,000 U/mg. Image Credit: Sino Biological US Inc
Human LIF protein
(Cat#: 14890-HNAH)
Activity-validated: Inhibited the proliferation of M1 mouse myeloid leukemia cells. Image Credit: Sino Biological US Inc
More cytokines for stem cell research (partial)
Source: Sino Biological US Inc
| Cat# |
Cytokines |
Species |
Expression Host |
Purity |
Activity |
Endotoxin |
10429-HNAH
5 Citations |
Activin A |
Human, Mouse, Rat, Cynomolgus, Rhesus |
HEK293 Cells |
≥ 95 %
(SEC-HPLC) |
Active |
<10 EU/mg |
| 50659-M08H |
Activin A |
Mouse |
HEK293 Cells |
> 88 % |
Active |
<1.0 EU/μg |
| 10452-H08H |
OSM |
Human |
HEK293 Cells |
> 95 % |
Active |
<1.0 EU/μg |
10452-HNAH
2 Citations |
OSM |
Human |
HEK293 Cells |
≥ 95 %
(SEC-HPLC) |
Active |
<10 EU/mg |
50112-M08H
3 Citations |
OSM |
Mouse |
HEK293 Cells |
> 95 % |
Active |
<1.0 EU/μg |
GMP-10605-HNAE
4 Citations |
EGF |
Human |
E. coli |
≥ 95 %
(SEC-HPLC) |
Active |
<5 EU/mg |
10605-H01H
39 Citations |
EGF |
Human |
HEK293 Cells |
> 90 % |
Active |
<1.0 EU/μg |
50482-M01H
5 Citations |
EGF |
Mouse |
HEK293 Cells |
> 95 % |
Active |
<1.0 EU/μg |
50482-MNAY
2 Citations |
EGF |
Mouse |
Yeast |
> 95 % |
Active |
|
70013-D07E
1 Citation |
EGF |
Canine |
E. coli |
> 98 % |
Active |
|
80446-RNAE
2 Citations |
EGF |
Rat |
E. coli |
> 95 % |
Active |
|
11066-HNAH
9 Citations |
VEGFA |
Human, Cynomolgus |
HEK293 Cells |
≥ 95 %
(SEC-HPLC) |
Active |
<10 EU/mg |
| 11066-H27H-B |
VEGFA |
Human, Cynomolgus |
HEK293 Cells |
> 95 % |
Active |
<1.0 EU/μg |
63004-ZNAB
7 Citations |
VEGFA |
Danio rerio (zebrafish) |
Baculovirus-
Insect Cells |
> 90 % |
Active |
<1.0 EU/μg |
| 11858-H08H |
IL3 |
Human |
HEK293 Cells |
> 95 % |
Active |
<1.0 EU/μg |
11858-HNAE
2 Citations |
IL3 |
Human |
E. coli |
≥ 95 %
(SEC-HPLC) |
Active |
<5 EU/mg |
51066-MNAH
1 Citation |
IL3 |
Mouse |
HEK293 Cells |
> 95 % |
Active |
<1.0 EU/μg |
80235-R08B
1 Citation |
IL3 |
Rat |
Baculovirus-
Insect Cells |
> 95 % |
Active |
<1.0 EU/μg |
14890-H08H
4 Citations |
LIF |
Human |
HEK293 Cells |
> 95 % |
Active |
<1.0 EU/μg |
50756-MNAH
6 Citations |
LIF |
Mouse |
HEK293 Cells |
> 95 % |
Active |
<1.0 EU/μg |
10014-HNAE
51 Citations |
FGF2 |
Human |
E. coli |
> 95 % |
Active |
<1.0 EU/μg |
50037-M07E
6 Citations |
FGF2 |
Mouse |
E. coli |
> 95 % |
Active |
|
10463-HNAS
20 Citations |
HGF |
Human |
CHO Stable Cells |
≥ 95 %
(SEC-HPLC) |
Active |
<0.01 EU/μg |
50038-MNAH
4 Citations |
HGF |
Mouse |
HEK293 Cells |
> 95 % |
Active |
<1.0 EU/μg |
80429-RNAH
2 Citations |
HGF |
Rat |
HEK293 Cells |
> 85 % |
Active |
<1.0 EU/μg |
10451-H08B
2 Citations |
SCF |
Human |
Baculovirus-
Insect Cells |
> 92 % |
Active |
<1.0 EU/μg |
| 10451-HNAE |
SCF |
Human |
E. coli |
≥ 95 %
(SEC-HPLC) |
Active |
<10 EU/mg |
| 50487-M08B |
SCF |
Mouse |
Baculovirus-
Insect Cells |
≥ 90 %
(SEC-HPLC) |
Active |
<1.0 EU/μg |
| 10609-HNAE2 |
BMP4 |
Human |
E. coli |
≥ 95 % |
Active |
<1.0 EU/μg |
50439-M15H
11 Citations |
BMP4 |
Mouse |
HEK293 Cells |
> 92 % |
Active |
<1.0 EU/μg |
10804-H08H
15 Citations |
TGF-β |
Human |
HEK293 Cells |
> 95 % |
Active |
<1.0 EU/μg |
10804-HNAC
26 Citations |
TGF-β |
Human, Rhesus, Cynomolgus, Canine |
CHO Stable Cells |
> 95 % |
Active |
<1.0 EU/μg |
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To learn more about products, please visit Sino Biological