Severe Acute Respiratory Syndrome News and Research

Latest Severe Acute Respiratory Syndrome News and Research

Elevated Activin A and FLRG levels correlate with worst outcomes in severe COVID-19

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes a "cytokine storm" in hospitalized and ICU patients. Studies have shown that the blockade of cytokine signaling and steroid treatment helps achieve positive outcomes in patients.

15 Feb 2021

CDC says vaccinated individuals can skip COVID quarantines

The coronavirus disease (COVID-19) pandemic's global case toll has surpassed 109 million globally. Of these infections, 2.4 million people have already succumbed to the disease. As the pandemic continues to spread, many countries have rolled out vaccinations.

15 Feb 2021

What makes some people COVID superspreaders?

The study, published in the journal Proceedings of the National Academy of Sciences, showed that older, obese people who have an acute COVID-19 infection release more aerosols, increasing viral transmission potential.

15 Feb 2021

Nanoparticle COVID-19 vaccine stimulates robust and long lasting immunity in primates

In the study, published on the preprint server bioRxiv, the team evaluated the ability of AS03, CpG 1018 formulated in Alum, the TLR-7 agonist adsorbed to Alum (AS37), the squalene-in-water emulsion (O/W), and Alum to boost protective immunity against SARS-CoV-2.

15 Feb 2021

How SARS-CoV-2 enters the central nervous system

The central nervous system (CNS) is highly protected in the human body. Yet, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) invades the CNS, causing profound clinical complications. How is the CNS involved in a respiratory virus infection?

15 Feb 2021

Researchers report a new SARS-CoV-2 variant of concern in Uganda

An interdisciplinary research team from Uganda and the UK report the emergence and spread of a new SARS-CoV-2 variant of the A lineage with multiple protein changes throughout the viral genome.

15 Feb 2021

Researchers observe rapid increase of SARS-CoV-2 antibodies in plasma over pandemic's course

Researchers found that neutralizing antibodies against SARS-CoV-2 can increase over time. They observed that samples taken from convalescent plasma in September 2020 would likely have high enough values by July 2021 to protect immunodeficient patients who receive intravenous immunoglobulins as part of their treatment.

15 Feb 2021

SARS-CoV-2 South Africa and Brazil variants show resistance to therapeutic antibodies

Scientists from Germany have determined the efficacy of currently used therapeutics in treating newer variants of SARS-CoV-2, including the UK, South Africa, and Brazil variants. Their findings reveal that both B.1.351 and B.1.1.248 variants are able to escape humoral immune responses induced by therapeutic antibodies, vaccinations, or natural SARS-CoV-2 infection.

15 Feb 2021

RIG-1-like receptors may play dominant role in suppressing SARS-CoV-2 infection

A new study by researchers at the University of Connecticut Health Center, USA, reports the crucial nature of the pathogen pattern recognition receptor (PRRs), especially the two RLRs, retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated protein 5 (MDA5), in triggering host cell immune responses within the cell. The RLRs are viral RNA sensors.

15 Feb 2021

Researchers develop protocols for rapid serological surveys of SARS-CoV-2 infection

A new study by researchers from Emory and Yale Universities in the USA discusses a design for quickly launching serological surveys to assess the prevalence of this infection in a given population.

15 Feb 2021

High-throughput sequencing could allow detection of new SARS-CoV-2 variants in wastewater

A new study reports the use of metagenomics to detect the virus from wastewater samples, indicating community-level circulating variants that are not yet identified or are present in very low proportions on clinical databases.

15 Feb 2021

Immunosuppressive therapies may be linked to severe COVID-19 in those with multiple sclerosis

A new study examines the associations between immunosuppressive disease-modifying therapies (DMTs) used in MS with adverse outcomes in an international cohort of patients with MS COVID-19.

15 Feb 2021

Researchers study host and viral transcriptomes in tandem to shed light on SARS-CoV-2 infection

In a new study, researchers discuss the use of simultaneous sequencing of both human and viral genes to better understand SARS-CoV-2's infection pathway.

15 Feb 2021

Nanobodies protect against SARS-CoV-2 variants in animal model

Nanobodies are a potential therapeutic strategy for treating COVID-19. While many previous studies report nanobodies active against SARS-CoV-2 in vitro, none have been evaluated via animal models' intranasal administration.

15 Feb 2021

Only 25% of SARS-CoV-2 infections are detected in the UK: Study

A new preprint research paper posted to the medRxiv server estimates the number of infections that are diagnosed from testing alone as being about a fourth of the total.

15 Feb 2021

Premature relaxation of restrictions following SARS-CoV-2 vaccination could lead to new mutations

A new preprint research paper posted to the medRxiv* server addresses the need to assess this risk by examining whether SARS-CoV-2 transmission can interact with vaccination rates to select vaccine-resistant strains. The study aims to provide data to shape effective countermeasures against the threat of viral resistance.

14 Feb 2021

Naïve B cells can neutralize SARS-CoV-2 via RBD recognition

A new preprint research paper posted to the bioRxiv server demonstrates the potential of using the pre-existing protective responses to produce a broad-spectrum neutralizing response against not just SARS-CoV-2 but other future pathogens.

14 Feb 2021

New mouse model of SARS-CoV-2 infection reflects features of human infection

Now, a new preprint research paper posted to the bioRxiv server reports the development of a modified mouse model that allows productive SARS-CoV-2 infection of the mouse lungs, as well as the exploration of type I and III interferon responses in this condition.

14 Feb 2021

SARS-CoV-2's resistance to remdesivir in vitro

A new preprint research paper posted to the bioRxiv server discusses the emergence of mutations in the SARS-CoV-2 virus, allowing it to escape the effects of the most commonly used antiviral drug, remdesivir.

14 Feb 2021

SARS-CoV-2 was in NYC a good month before it was first identified, say researchers

Researchers at Icahn School of Medicine at Mount Sinai in New York have provided evidence suggesting that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19) – was infecting people in New York City (NYC) at least one month before the first case was officially documented in the city.

14 Feb 2021

Severe Acute Respiratory Syndrome News and Research

Latest Severe Acute Respiratory Syndrome News and Research

Elevated Activin A and FLRG levels correlate with worst outcomes in severe COVID-19

CDC says vaccinated individuals can skip COVID quarantines

What makes some people COVID superspreaders?

Nanoparticle COVID-19 vaccine stimulates robust and long lasting immunity in primates

How SARS-CoV-2 enters the central nervous system

Researchers report a new SARS-CoV-2 variant of concern in Uganda

Researchers observe rapid increase of SARS-CoV-2 antibodies in plasma over pandemic's course

SARS-CoV-2 South Africa and Brazil variants show resistance to therapeutic antibodies

RIG-1-like receptors may play dominant role in suppressing SARS-CoV-2 infection

Researchers develop protocols for rapid serological surveys of SARS-CoV-2 infection

High-throughput sequencing could allow detection of new SARS-CoV-2 variants in wastewater

Immunosuppressive therapies may be linked to severe COVID-19 in those with multiple sclerosis

Researchers study host and viral transcriptomes in tandem to shed light on SARS-CoV-2 infection

Nanobodies protect against SARS-CoV-2 variants in animal model

Only 25% of SARS-CoV-2 infections are detected in the UK: Study

Premature relaxation of restrictions following SARS-CoV-2 vaccination could lead to new mutations

Naïve B cells can neutralize SARS-CoV-2 via RBD recognition

New mouse model of SARS-CoV-2 infection reflects features of human infection

SARS-CoV-2's resistance to remdesivir in vitro

SARS-CoV-2 was in NYC a good month before it was first identified, say researchers

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

Severe Acute Respiratory Syndrome News and Research

Latest Severe Acute Respiratory Syndrome News and Research

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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