Life Science White Papers

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Life Science White Papers are in-depth articles aimed to educate and inform site visitors interested in life science research. Some of these papers are derived from sources where we have existing commercial relationships. Such articles are clearly labelled as sponsored content and are only accepted when the content is deemed to add value to the core editorial ethos of News Medical.

Genome Wide Comparison of N-ChIP and X-ChIP Using Solid State Chromatrap® Spin Column Technology

This article presents a comprehensive genome wide comparison of native and cross linked chromatin immunoprecipitation (ChIP) and next generation sequencing (ChIP-seq) using the patented solid state Chromatrap® spin column technology.

From Chromatrap® - Porvair Sciences Ltd 5 Jun 2017

Using AFM to Visualize Lipid Content in Stratum

In this article, the variable lipid content present in stratum corneum is visualized and compared at high spatial resolution using atomic force microscopy (AFM).

From Bruker Nano Surfaces and Metrology 31 May 2017

Using CLARIOstar® Microplate Reader for Real-Time Detection of Gi and Gs Signaling in Living Cells

Toward the end of these drug screenings, positive hits have to be confirmed in living cells related to disease, for example, iPSC derived cell lines.

From BMG LABTECH GmbH 25 May 2017

Smart temperature control enhances PCR sample preparation

Who said you can’t teach and old dog new tricks? Latest advancements say otherwise One of the most widely used techniques in molecular biology is polymerase chain reaction (PCR), a method used to amplify small sections of DNA or RNA in a sample by adding primers, nucleotides, DNA polymerase and other reagents.

From Vitl Life Science Solutions 25 May 2017

fMRI Used to Identify Neuronal Networks Activated by VTA or Hippocampal CA3 Stimulation

Functional magnetic resonance (fMRI) imaging can provide insight into hemodynamic shifts that occur in blood, including blood volume, flow, and oxygenation. The technique can also be used to map neuronal networks and detect synchronized activities within the brain.

From Bruker BioSpin - NMR, EPR and Imaging 23 May 2017

Integrated CLEM and Scanning Electron Microscopes Help Gain New Insights into Blood Disorders

Blood is an essential component of the body, supplying necessary oxygen to all organs and tissues and eliminating unwanted metabolites from cells. However, in addition to transporting oxygen, blood protects the body from a variety of diseases using the immune cells and platelets present in it. These blood cells also play a role in bleeding disorders.

From Thermo Fisher Scientific Phenom-World BV 22 May 2017

High Quality Blood Agar Production Using DOSE IT and MEDIA JET

Blood agar plates composed of 5-10% defibrinated animal blood (for example, bovine, sheep) are widely used to detect hemolytic activities.

From INTEGRA Biosciences 22 May 2017

FFF for Quantification of Monoclonal Antibody Aggregates

Protein aggregation needs to be addressed for the successful development and quality control of pharmaceutical formulations.

From Postnova Analytics 10 May 2017

Size-Distribution Analysis of Monodisperse Gold Nanoparticles

Nanoparticles (NPs) have become ubiquitous nowadays and are increasingly being used in many different products.

From Postnova Analytics 10 May 2017

Temperature-Induced Antibody Decomposition

Asymmetrical Flow FFF (AF4) is the preferred method for the characterization of recombinant antibodies.

From Postnova Analytics 10 May 2017

Ergonomics of Pipette Use and Handling

Pipettes are usually used to perform reactions that involve chemical reagents. Working with chemicals always involves risks.

From INTEGRA Biosciences 10 May 2017

Untangling the Lipid Paradox in Rheumatoid Arthritis

Cardiovascular disease (CVD) is a major cause of mortality in people with rheumatoid arthritis (RA) – a long-term autoimmune disorder that causes pain, swelling, and stiffness in the joints. People with RA have around a 50% higher cardiovascular risk than those in the general population.

From Bruker BioSpin - NMR, EPR and Imaging 26 Apr 2017

Using homoFRET-FP Detection for Monitoring Insulin Granule Packaging in Live Cells

It was believed that an HF-FP approach is appropriate to track the level of storing mature insulin into dense core granule.

From BMG LABTECH GmbH 21 Apr 2017

Eight Reasons to Use MicroCal PEAQ-DSC Automated System

During biopharmaceutical drug development, differential scanning calorimetry (DSC) is used to evaluate protein stability. The data provided by this established biophysical tool is employed to advance the most 'developable' and stable proteins into the pipeline, and improve the formulation and process conditions to sustain protein stability during manufacturing and storage of drugs.

From Malvern Panalytical 21 Apr 2017

Using Differential Scanning Calorimetry for Biosimilarity and Batch-to-Batch Comparability

The success or failure of the development of a biopharmaceutical product is governed by protein stability. Protein stability is considered a critical parameter during manufacturing, production, formulation, long term storage, efficacy, and delivery to patients.

From Malvern Panalytical 21 Apr 2017

Viewing Foodborne Pathogens through Light and Electron Microscopes

Foodborne pathogens refer to microbes found in farm, zoo, and pet animals and to microbes found in the environment (water, soil, air) that make human beings fall sick, irrespective of the infection path.

From Thermo Fisher Scientific Phenom-World BV 21 Apr 2017

High Sensitivity Detection of Montana Molecular’s Genetically Encoded Sensors Using CLARIOstar®

Genetically encoded, fluorescent biosensor-based live cell assays are advantageous in many ways over end point assays in cell lysates.

From BMG LABTECH GmbH 10 Apr 2017

KBI Biopharma Gains Commercial Benefit Using Malvern Instruments

The Particle Characterization Core Facility based at KBI Biopharma in Boulder, Colorado, is managed by Dr. Amber Fradkin. Headquartered in Durham, North Carolina, KBI is a biopharmaceutical contract development and manufacturing organization (CDMO) that focuses on expediting the development of biological therapeutics.

From Malvern Panalytical 5 Apr 2017

Detection of Standard Absorbance-Based Protein Quantification Assays Using BMG LABTECH Readers

Absorbance-based protein quantification assays are often Routine analysis performed in life science laboratories.

From BMG LABTECH GmbH 3 Apr 2017

Application of Laser-Doppler Vibrometers in Hearing and Biomechanics

Laser vibrometry is used for research and diagnostics on the inner and middle ear. Vibrometers have also been used for measuring vibration on artificial heart valves to analyze vibrations during medical laser ablation or bone drilling, investigate the mechanical properties of tendons, and detect the propagation of bone cracks.

From Polytec 29 Mar 2017

Life Science White Papers

Genome Wide Comparison of N-ChIP and X-ChIP Using Solid State Chromatrap® Spin Column Technology

Using AFM to Visualize Lipid Content in Stratum

Using CLARIOstar® Microplate Reader for Real-Time Detection of Gi and Gs Signaling in Living Cells

Smart temperature control enhances PCR sample preparation

fMRI Used to Identify Neuronal Networks Activated by VTA or Hippocampal CA3 Stimulation

Integrated CLEM and Scanning Electron Microscopes Help Gain New Insights into Blood Disorders

High Quality Blood Agar Production Using DOSE IT and MEDIA JET

FFF for Quantification of Monoclonal Antibody Aggregates

Size-Distribution Analysis of Monodisperse Gold Nanoparticles

Temperature-Induced Antibody Decomposition

Ergonomics of Pipette Use and Handling

Untangling the Lipid Paradox in Rheumatoid Arthritis

Using homoFRET-FP Detection for Monitoring Insulin Granule Packaging in Live Cells

Eight Reasons to Use MicroCal PEAQ-DSC Automated System

Using Differential Scanning Calorimetry for Biosimilarity and Batch-to-Batch Comparability

Viewing Foodborne Pathogens through Light and Electron Microscopes

High Sensitivity Detection of Montana Molecular’s Genetically Encoded Sensors Using CLARIOstar®

KBI Biopharma Gains Commercial Benefit Using Malvern Instruments

Detection of Standard Absorbance-Based Protein Quantification Assays Using BMG LABTECH Readers

Application of Laser-Doppler Vibrometers in Hearing and Biomechanics

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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