Life Science White Papers

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Life Science White Papers are in-depth articles aimed to educate and inform site visitors interested in life science research. Some of these papers are derived from sources where we have existing commercial relationships. Such articles are clearly labelled as sponsored content and are only accepted when the content is deemed to add value to the core editorial ethos of News Medical.

Electron Paramagnetic Resonance Aids Cancer Drug Development

Chromosome instability is a key hallmark of cancers, increasing mutation rates and helping tumor cells evade destruction by the immune system as well as treatment by medical interventions. Hypoxia contributes to this instability, causing replication stress and a subsequent loss of the cellular machinery required to deal with DNA damage.

From Bruker BioSpin - NMR, EPR and Imaging 30 Aug 2017

GoTaq® MDx Hot Start Polymerase: A General Purpose Reagent for Molecular Diagnostic Assays

Many PCR-based molecular diagnostic tests utilize a hot-start thermostable DNA polymerase.

From Promega Corporation 21 Aug 2017

Adopting a Best-in-Class Strategy for Digital Pathology

Anyone who is tasked with implementing a digital pathology workflow faces a dilemma - do you buy from a single vendor or take a best-in-class approach?

From Huron Digital Pathology 16 Aug 2017

Solid Fat Content Determination by Time Domain (TD) NMR Analysis

Determining solid fat content (SFC) is important in the processing and development of food products. It is essential to characterize and control raw materials like fat compositions or blends in accordance with their melting profiles.

From Bruker BioSpin - NMR, EPR and Imaging 11 Aug 2017

Using EPA 300 Method for Determination of Anions in Tap Water

Maximum Contamination Levels in drinking water are established by EPA through the Safe Drinking Water Act. EPA controls industry discharge MCL.

From Metrohm USA Inc. 9 Aug 2017

Trends and Developments of Ion Chromatography in Pharmaceutical Analysis

As a highly flexible technique, ion chromatography (IC) has many practical applications in the pharmaceutical field.

From Metrohm USA Inc. 9 Aug 2017

On-Field Determination of Arsenic, Mercury, and Copper in Ground Water

Mercury and arsenic are examples of heavy metals that can be found in ground water across many parts of the world.

From Metrohm USA Inc. 9 Aug 2017

Determination of Glyphosate and AMPA in Drinking Water Using Ion Chromatography with Pulsed Amperometric Detection

Glyphosate is a broad-spectrum herbicide that is widely used in agriculture across the globe.

From Metrohm USA Inc. 9 Aug 2017

Advantages of Using a Peristaltic Pump to Transfer Liquids

Ensuring proper liquid transfer with high precision and free of contamination is a key challenge in using pumps for liquid transfer.

From INTEGRA Biosciences 8 Aug 2017

High Resolution BOLD Functional MRI Provides New Insights on Rat Brain

Four-element array coils and high field small animal MR scanners can be used to obtain functional MRI, also known as fMRI, at a high spatial resolution of 75 x 75 x 1000 μm3. The activation area contains fine and detailed substructures, which can be identified at unparalleled in vivo resolution, thereby widening the scope and understanding of the origin and biophysical principles of blood-oxygenation-level dependent (BOLD) to get a better insight into structure and organization of the brain.

From Bruker BioSpin - NMR, EPR and Imaging 4 Aug 2017

A Guide to Buying CO2 Incubators

CO2 incubators are available in two basic types – direct heat CO2 incubator and water-jacketed CO2 incubator.

From NuAire 2 Aug 2017

Points to Consider When Purchasing Ultra-Low Temperature Freezers

Although ULT freezers are designed to work between -86°C and -45°C, they often work at a set temperature. These freezers can last for about 12 to 15 years.

From NuAire 2 Aug 2017

Assessing the Loading Capacity of HEPA Filters

When it comes to the life cycle cost of any Biological Safety Cabinet (BSC), the life of a HEPA filter is crucial.

From NuAire 2 Aug 2017

Genetically Engineering Rat Gliomas to Enable Clinically Relevant Imaging of Human Glioblastoma

Glioblastoma (GBM) is a highly malignant and aggressive primary cancer of the central nervous system. In GBM, the brain tumor or glioma arises from normal brain cells (astrocytes) and then grows very quickly, invading and residing in healthy brain tissue.

From Bruker BioSpin - NMR, EPR and Imaging 1 Aug 2017

Advantages and Applications of Bruker’s MRI CryoProbe Series

The MRI CryoProbe series from Bruker has superior resolution and provides the ultimate image with unmatched performance. MRI CryoProbes are equipped with very low temperatures, closed-cycle cooled RF-coils and preamplifiers, delivering an increased signal-to-noise ratio (SNR) by a factor of 2.5 in routine in vivo MRI applications at 9.4 T when compared to standard room temperature 1H RF-coils.

From Bruker BioSpin - NMR, EPR and Imaging 28 Jul 2017

Harnessing the power of CRISPR through accurate sample prep

CRISPR technology burst onto the scene in 2012,1 and has been a staple of scientific research ever since. CRISPR offers the promise of personalized medicine on a level previously unattainable, and clinical trials are already underway using the technology in China.

From Vitl Life Science Solutions 25 Jul 2017

Using NanoBiT® Technology to Study the Dynamics of Protein Interactions in Live Cells

NanoLuc® Binary Technology, also known as NanoBiT, is an innovative binary complementation solution built on NanoLuc® Luciferase (1).

From Promega Corporation 24 Jul 2017

Normalization: An Essential Part of Bioluminescent Reporter Assay

There are types of experimental methods that often use normalization to fix the differences induced by factors other than what is immediately being analyzed.

From Promega Corporation 24 Jul 2017

Using Calorimetric Methods to Investigate Protein Misfolding and Aggregation

Under the right physiological conditions for gain of function, unfolded proteins can fold into native structures that are thermodynamically-favorable, as illustrated in Figure 1. Native structures are stabilized and solubility is ensured as a result of embedded hydrophobic regions within the protein's interior and also the fact that hydrophilic residues are exposed to aqueous solutions.

From Malvern Panalytical 20 Jul 2017

Using Dynamic Light Scattering to Screen Colloidal Aggregates of Small-Molecule Drugs

It is an extremely tedious task to identify new small-molecule drugs through high-throughput screening (HTS). As a result, engineers and scientists have collaborated to automate the entire process of trudging through indefinite number of compounds, evaluating their binding to proteins of interest and searching for the few precious compounds that indeed bind.

From Waters | Wyatt Technology 19 Jul 2017