The Thermo ScientificTM MarqMetrixTM All-in-One Process Raman Analyzer is a Raman spectroscopy instrument aimed towards delivering rapid, powerful, scalable, and reliable identification, quantification, and characterization of molecules at all phases of research and development (R&D) process development.
As a combined “all-in-one” instrument, it leverages the functionalities of interchangeable, autoclavable probes to meet the analytical demands of, but not restricted to, upstream bioprocess monitoring or characterization of fill and finish products. This device represents a breakthrough in process analytical technology (PAT), offering in-line, real-time, and actionable monitoring of multiple analytes in complex systems.
Image Credit: Thermo Fisher Scientific – Portable and Handheld Raman Spectroscopy
This article presents a study showcasing the effective transferability of a single chemometric model across ten different MarqMetrix All-In-One Process Raman Analyzers.
It highlights that measurement accuracy and precision are consistently maintained when applying a chemometric model across multiple instruments. This ensures that users are not required to invest additional time or resources into developing a new model for each MarqMetrix All-In-One Process Raman Analyzer or whenever a new autoclavable probe is introduced.
For a deeper understanding of this case study and its implications for improving efficiency in the application of Raman spectroscopy technology across various analytical environments, please download the full article here.
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About Thermo Fisher Scientific – Portable and Handheld Raman Spectroscopy
Thermo Fisher Scientific offers innovative solutions that help our customers solve complex analytical challenges, accelerate life sciences manufacturing, deliver medicines to market, and increase laboratory productivity. Our Thermo Scientific portable and handheld process Raman analyzers enable accurate, real-time results for process monitoring.
The Thermo Scientific™ MarqMetrix™ All-In-One Process Raman Analyzer is an all-in-one system purpose-built for rapid deployment, ease of use, and scalability in markets where time-to-results is critical. The MarqMetrix All-In-One Process Raman Analyzer is designed for:
- Analysis without sample preparation, delivering Raman spectral results in real-time
- Easy setup and deployment by non–Raman spectroscopists
- Non-destructive workflows to protect precious samples
- Non-invasive handling to minimize contamination of samples
- Small footprint for convenient deployment
- Factory calibration for hardware stability and portability
The Thermo Scientific TruScan™Handheld Raman Analyzers includes state-of-the-art optics paired with a patented multivariate residual analysis that offers an effective chemometric solution for material identification, with two spectral pre-processing options. The non-destructive point-and-shoot sampling principle facilitates rapid verification of a broad range of chemical compounds, including cellulose-based products.
The TruScan™ G3 Handheld Raman Analyzer continues the evolution of raw material ID testing for pharmaceutical and biotechnology manufacturing quality control processes with:
- Incoming raw material identification (RMID)
- Dispensing of materials during API manufacture
- Finished product inspection
- Identification of falsified (counterfeit) medicines
- Enables non-technical operators to rapidly perform raw material ID testing without the need of a lab
The TruScan™ RM Handheld Raman Analyzer takes pharmaceutical manufacturing QA/QC to the next level with:
- Enhanced 21 CFR Part 11 and cGMP compliance with biometric login, complex password options, and full audit trail features
- Non-contact analysis through plastic bags, glass containers, blister packs and clear gel caps
- Intuitive workflow adapted to production environment through PDF batch reports and ease of data input using barcode scanners
- Easy fleet management feature that enables cloning of instruments and identification methods
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