Cultivated meat, also known as lab-grown or cell-based meat, is a fast-growing industry that strives to create an ethical, sustainable alternative to traditional animal agriculture. Although vast advancements have been achieved recently, the production process and quality and consistency of the product require optimization.
Raman spectroscopy, a non-destructive technique for identifying and quantifying a sample’s chemical composition, has shown potential for addressing such challenges. It can analyze the intricate components of cultivated meat and has many benefits over other methods, which are summarized below.
Improved process-monitoring
Maintaining consistent quality across batches is one of the biggest challenges in this industry. Raman spectroscopy can be utilized to monitor the composition of cell culture media, the growth medium for the cultivation of the cells, ensuring it remains consistent and contaminant-free.
By monitoring growth medium, it becomes possible to enhance the nutrient composition, improving cell quality and growth.
Quicker analysis
Unlike traditional techniques, which can take days to produce results, Raman spectroscopy can produce results within minutes, significantly reducing manufacturing costs and time and allowing real-time monitoring and adjustments to the process.
Improved affordability
Monitoring and optimizing production in real time helps reduce waste and realize more efficient outcomes. The Thermo Scientific™ MarqMetrix™ All-In-One Process Raman Analyzer does not require expensive consumables or continuous calibration like other classic techniques, considerably lowering costs for the manufacturer.
Non-destructive analysis
Most classic techniques require destructive sample preparation; Raman spectroscopy is a non-destructive method for identifying and analyzing samples. Combined with in-line monitoring and contactless use, this guarantees that samples stay intact and can be used again, which reduces waste and additional production.
High specificity and accuracy
As an accurate and specific method for identifying compounds within a sample, Raman spectroscopy is a perfect tool for classifying and quantifying complex components (such as lipids, proteins and nucleic acids) of cultivated meat.
By quantifying chemical compositions, production processes can be optimized to meet regulatory requirements and ensure consistency.
Flexibility
A range of samples can be analyzed with Raman spectroscopy, whether gas, liquid, or solid, making it a versatile method for analysis at different stages within the process.
Scalability
As demand for cultivated meat increases, stakeholders must explore ways to optimize processes and improve affordability. With a method that reduces production time and waste, companies will be able to produce more meat at lower costs for themselves and consumers.
Conclusion
Raman spectroscopy provides a range of benefits for the production of cultivated meat, including high accuracy, specificity and versatility, improved monitoring, faster production times and non-destructive analysis.
Through the utilization of Raman spectroscopy, companies will be able to improve production and ensure consistency in quality.
As the industry grows, the need for quality control and regulatory compliance will increase. The improvements to specificity and accuracy Raman spectroscopy guarantees will ensure cultivated meat products meet these requirements.
About Thermo Fisher Scientific – Portable and Handheld Raman Spectroscopy
Thermo Fisher Scientific offers innovative solutions that help our customers solve complex analytical challenges, accelerate life sciences manufacturing, deliver medicines to market, and increase laboratory productivity. Our Thermo Scientific portable and handheld process Raman analyzers enable accurate, real-time results for process monitoring.
The Thermo Scientific™ MarqMetrix™ All-In-One Process Raman Analyzer is an all-in-one system purpose-built for rapid deployment, ease of use, and scalability in markets where time-to-results is critical. The MarqMetrix All-In-One Process Raman Analyzer is designed for:
- Analysis without sample preparation, delivering Raman spectral results in real-time
- Easy setup and deployment by non–Raman spectroscopists
- Non-destructive workflows to protect precious samples
- Non-invasive handling to minimize contamination of samples
- Small footprint for convenient deployment
- Factory calibration for hardware stability and portability
Our Thermo Scientific TruScan™ Handheld Raman Analyzers includes state-of-the-art optics paired with a patented multivariate residual analysis that offers an effective chemometric solution for material identification, with two spectral pre-processing options. The non-destructive point-and-shoot sampling principle facilitates rapid verification of a broad range of chemical compounds, including cellulose-based products.
The TruScan™ G3 Handheld Raman Analyzer continues the evolution of raw material ID testing for pharmaceutical and biotechnology manufacturing quality control processes with:
- Incoming raw material identification (RMID)
- Dispensing of materials during API manufacture
- Finished product inspection
- Identification of falsified (counterfeit) medicines
- Enables non-technical operators to rapidly perform raw material ID testing without the need of a lab
The TruScan™ RM Handheld Raman Analyzer takes pharmaceutical manufacturing QA/QC to the next level with:
- Enhanced 21 CFR Part 11 and cGMP compliance with biometric login, complex password options, and full audit trail features
- Non-contact analysis through plastic bags, glass containers, blister packs and clear gel caps
- Intuitive workflow adapted to production environment through PDF batch reports and ease of data input using barcode scanners
- Easy fleet management feature that enables cloning of instruments and identification methods
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