Manufacturing processes are often complex and intricate processes, particularly in the area of biopharmaceutical manufacturing. With methods heavily reliant on living organisms to deliver products of interest, as with those in the biopharma industry, having a comprehensive understanding of the process is the key to success in enabling close control of the exercises involved.
Process analytical instruments and technologies aim to alleviate issues around visibility, or a lack thereof, regarding the underlying reactions in these processes. You will better understand what you see, which, in turn, offers enhanced control and optimization strategies.
ThermoFisher Scientific is dedicated to manufacturing instruments that allow its customers to gain greater control of their processes that involve chemistry. One of the most advantageous and powerful analytical technologies that ThermoFisher uses is Raman spectroscopy. Extremely accurate and versatile, Raman spectroscopy yields rapid results, encompasses a multitude of functions, and is a non-destructive sample analysis method.
Previously, trained technicians were required to conduct Raman Spectroscopy and operate the complex, bulky, and expensive equipment that was often confined to the laboratory, making it unsuitable for in-line or field use.
Image Credit: Thermo Fisher Scientific – Portable and Handheld Raman Spectroscopy
ThermoFisher has recently unveiled the Thermo Scientific™ MarqMetrix™ All-in-One Process Raman Analyzer, an easy-to-use, compact, reliable, and cost-effective system that uses the power of Raman spectroscopy to measure important variable process factors making them easier to control.
Through its simple, user-friendly interface, the MarqMetrix All-in-One Process Raman Analyzer makes Raman technology more accessible to non-experts. Moreover, the compact size of the device addresses the portability issue commonly faced by those who use chemistry to make things in the field or in the process development space.
This article will provide more information on this new product, outlining why it could be advantageous to both professionals in the field as well as non-experts.
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About Thermo Fisher Scientific – Portable and Handheld Raman Spectroscopy
Thermo Fisher Scientific offers innovative solutions that help our customers solve complex analytical challenges, accelerate life sciences manufacturing, deliver medicines to market, and increase laboratory productivity. Our Thermo Scientific portable and handheld process Raman analyzers enable accurate, real-time results for process monitoring.
Our Thermo Scientific™ MarqMetrix™ All-In-One Process Raman Analyzer is an all-in-one system purpose-built for rapid deployment, ease of use, and scalability in markets where time-to-results is critical. The Ramina Process Analyzer is designed for:
- Analysis without sample preparation, delivering Raman spectral results in real-time
- Easy setup and deployment by non–Raman spectroscopists
- Non-destructive workflows to protect precious samples
- Non-invasive handling to minimize contamination of samples
- Small footprint for convenient deployment
- Factory calibration for hardware stability and portability
Our Thermo Scientific TruScan RM Handheld Raman Analyzer includes state-of-the-art optics paired with a patented multivariate residual analysis that offers an effective chemometric solution for material identification, with two spectral pre-processing options. The analyzer’s non-destructive point-and-shoot sampling principle facilitates rapid verification of a broad range of chemical compounds, including cellulose-based products.
The TruScan RM Handheld Raman Analyzer takes pharmaceutical manufacturing QA/QC to the next level with:
- Enhanced 21 CFR Part 11 and cGMP compliance with biometric login, complex password options, and full audit trail features
- Non-contact analysis through plastic bags, glass containers, blister packs and clear gel caps
- Intuitive workflow adapted to production environment through PDF batch reports and ease of data input using barcode scanners
- Easy fleet management feature that enables cloning of instruments and identification methods
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