Interferon News and Research

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Safety and immunogenicity of different COVID-19 booster vaccines

New study findings suggest that booster vaccination with an mRNA-based vaccine has the highest immunogenicity against the COVID-19 Delta variant.

1 Dec 2021

Role of interferon type I-driven responses associated with disease control in COVID-19

New research suggests that treatment with type I interferons in the early stage of COVID-19 may supress disease progression by limiting SARS-CoV-2 in hosts.

1 Dec 2021

Northwestern researchers continue to tackle every facet of COVID-19 pandemic

As the COVID-19 pandemic nears the two-year mark, Northwestern Medicine scientists continue to tackle every facet of the disease, from investigating coronavirus vaccines' potential for providing immunity against similar coronaviruses to developing novel rapid antigen-based tests and examining disparities in COVID-19 case and mortality rates in Chicago.

30 Nov 2021

Human LRRC15 protein is an inhibitory receptor for SARS-CoV-2 spike-mediated entry

In a recent study, published on the bioRxiv* preprint server, researchers identified human LRRC15 as an inhibitory receptor for SARS-CoV-2 entry, which directly binds to the receptor-binding domain (RBD) of the spike protein with a moderate affinity and inhibits spike-mediated entry.

29 Nov 2021

Genetic variations affect and rewire phosphorylation signaling networks in SARS-CoV-2 infection

Researchers study human single nucleotide variants (SNVs) using machine learning to identify amino acid changes that alter kinase-bound sequence motifs.

29 Nov 2021

Severe COVID-19 may result in premature aging in recovered patients

As COVID-19 has been found to cause frontal cortex impairment similar to aging, the scientists in a recent study attempted to investigate if severe COVID-19 resulted in aging-related molecular signatures in the brain. The findings from this study are published as a preprint on the medRxiv* server.

28 Nov 2021

Study shows plasmacytoid dendritic cells may be a viable target for protection against SARS-CoV-2

A recent research paper by scientists from Denmark reveals that circulating plasmacytoid dendritic cells may be a potential therapeutic target to maintain desired levels of an antiviral compound known as interferon, allowing for the mitigation of coronavirus disease (COVID-19) severity. The study is currently available on the bioRxiv* preprint server while it undergoes peer review.

28 Nov 2021

Genetic ancestry can explain population-level differences in immune response to the flu virus

A new study aimed at explaining differential susceptibility to viral epidemics reveals that ancestry and associated genetic variation can explain population-level differences in the immune response to the flu virus and perhaps also to COVID-19.

26 Nov 2021

Immune response to influenza virus influenced by genetic ancestry

New research at the University of Chicago has found differences in immune pathway activation to influenza infection between individuals of European and African genetic ancestry.

25 Nov 2021

Safety and immunogenicity of COVID-19 peptide vaccine

In a study published in Nature, researchers from University Hospital Tübingen have been investigating the results from a Phase I trial for a new vaccine against SARS-CoV-2 variants.

25 Nov 2021

Maternal-fetal interface yields intriguing clues to how it battles SARS-CoV-2

Scientists have hypothesized that the number of immune cells and the amount of cytokines produced in response to SARS-CoV-2 infection in pregnant women change in accordance with the timing of maternal infection in pregnancy. This study is available on the bioRxiv* preprint server.

24 Nov 2021

An assessment of potential epitopes in SARS-CoV-2 structural proteins

Researchers utilized multiple bioinformatics resources to identify potent T- and B-cell epitopes of four SARS-CoV-2 structural proteins.

24 Nov 2021

Study finds rhinovirus reduces SARS-CoV-2 replication in airway epithelial cells

A recent study has demonstrated that SARS-CoV-2 infection induces a significantly lower interferon response than rhinovirus infection.

24 Nov 2021

Discovery of a broad-spectrum antiviral activity in self-assembling immunostimulatory duplex RNAs

A new study, published on the bioRxiv* preprint server, has discovered a class of new immunostimulatory RNAs while studying influenza infection-associated host genes in human lung epithelial cells using small interfering RNAs (siRNAs). Scientists revealed that these short duplex RNAs could induce type I and type III interferons (IFN-I/III) in a wide variety of cells.

23 Nov 2021

Interferon News and Research

Safety and immunogenicity of different COVID-19 booster vaccines

Role of interferon type I-driven responses associated with disease control in COVID-19

Northwestern researchers continue to tackle every facet of COVID-19 pandemic

Human LRRC15 protein is an inhibitory receptor for SARS-CoV-2 spike-mediated entry

Genetic variations affect and rewire phosphorylation signaling networks in SARS-CoV-2 infection

Severe COVID-19 may result in premature aging in recovered patients

Study shows plasmacytoid dendritic cells may be a viable target for protection against SARS-CoV-2

Genetic ancestry can explain population-level differences in immune response to the flu virus

Immune response to influenza virus influenced by genetic ancestry

Safety and immunogenicity of COVID-19 peptide vaccine

Maternal-fetal interface yields intriguing clues to how it battles SARS-CoV-2

An assessment of potential epitopes in SARS-CoV-2 structural proteins

Study finds rhinovirus reduces SARS-CoV-2 replication in airway epithelial cells

Discovery of a broad-spectrum antiviral activity in self-assembling immunostimulatory duplex RNAs

Oral Hsp90 inhibitor SNX-5422 interferes with replication machinery of SARS-CoV-2

Tobacco mosaic virus nanoparticle-based novel COVID-19 vaccine candidate

Interferon beta versus the SARS-CoV-2 Delta variant

IFITM proteins are important replication cofactors for SARS-CoV-2, including Delta variant

Preexisting rhinovirus infection and IFN induction in epithelium of asthma patients decreases SARS-CoV-2 infection

MIT researchers uncover a possible new way to combat tumors

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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