IL-21: A cytokine for modulating allergy, cancer and viral infections

Interleukin 21 (IL-21) belongs to the IL-2 class of cytokines strongly linked to autoimmunity and inflammation. Moreover, it has divergent impacts on lymphomas and lymphoid cell leukemia. Clinical trials using IL-21 have provided favorable outcomes in cancer treatment, while the development of IL-21 inhibitors is ongoing for the treatment of autoimmune diseases.

The significant sources of IL-21 are activated CD4+ T cells, such as natural killer (NK) T cells and T follicular helper (Tfh) cells. IL-21’s biological functions are interposed through a heterodimeric receptor including the IL-21R and the common γ-chain (γc/CD132) receptor.

The latter is shared with other cytokines from the IL-2 family (IL‐4, IL‐7, IL‐9 and IL‐15). The IL-21/IL-21R signaling triggers the Janus kinases (JAK1/JAK3), and then the STATs (STAT1/STAT3/STAT5) signaling pathways, to control the differentiation, proliferation, survival and functions of myeloid, lymphoid and epithelial cells.

Sino Biological has come up with a sequence of high-quality recombinant IL-21 and receptor proteins for the study of this cytokine.

Recombinant IL-21 cytokines and receptors

Sino Biological has specifically developed bioactive recombinant IL-21 cytokines obtained from numerous species, like mouse, rat, human and canine.

Featured IL-21 protein

Human IL-21 protein: 10584-HNAE: High purity, HPLC-verified, low endotoxin, high purity.

95% as determined by SEC-HPLC.

>95% as determined by SEC-HPLC. Image Credit: Sino Biological Inc.

Ability to induce Interferon-gamma secretion by human natural killer lymphoma NK-92 cells.

Ability to induce Interferon-gamma secretion by human natural killer lymphoma NK-92 cells. Image Credit: Sino Biological Inc.

Batch-to-batch Consistency.

Batch-to-batch Consistency. Image Credit: Sino Biological Inc.

Other recombinant IL-21 cytokines

Table 1. Source: Sino Biological Inc.

Cat# Species Tag Expressed Host Purity Activity
50137-MNAE Mouse Native E. coli >97% Active
70016-DNAE Canine Native E. coli >97% Active
80200-R08B Rat C-His Insect Cells >90% Active
80200-RNAE Rat Native E. coli >95%  

 

Recombinant IL-21 receptor: IL-12R

Table 2. Source: Sino Biological Inc.

Cat# Species Tag Activity
11483-H02H Human C-hFc  
11483-H08H Human C-His Active
51184-M02H Mouse C-hFc  
51184-M08H Mouse C-His  
80189-R05H Rat C-hFc  
80189-R08H Rat C-His Active
90315-C02H Cynomolgus, Rhesus C-hFc Active
90315-C08H Cynomolgus C-His  
 

Ability to inhibit IL-21-induced Interferon gamma secretion by human natural killer lymphoma NK-92 cells.

Ability to inhibit IL-21-induced Interferon gamma secretion by human natural killer lymphoma NK-92 cells. Image Credit: Sino Biological Inc.

Other related proteins

  • IL-4
  • IL-7
  • IL-9
  • IL-15
  • CD132

Antibodies for IL-21 cytokines and receptors

Sino Biological has come up with an extensive panel of antibodies that target IL-21 cytokines and receptors. This can be utilized in IHC, WB and ELISA.

  • Anti-IL21
  • Anti-IL21R

Other Equipment by this Supplier

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.