Seasonal flu is a common infectious disease of the respiratory tract and is caused by the influenza virus. There are four kinds of influenza virus: influenza type A, B, C, and D.

The A and B types have gained huge interest in the medical community since they are the criminals for seasonal epidemics. At times, influenza A, like the A/Hong Kong/1/1968 (H3N2), and A/California/04/09 (H1N1), can even result in global pandemics.

Influenza vaccine strains: Recombinant antigens from 2015-2023

Image Credit: Sino Biological Inc

Vaccination is considered the most effective method to avoid flu infection. Every year, various flu strains are chosen as vaccine candidates depending on surveillance data of the recent isolates and the performance of the vaccines from the earlier season.

Recently, the majority of the influenza vaccines are trivalent or quadrivalent, made of one H1N1, one H3N2, and either one or two type B viruses (Victoria lineage and Yamagata).

Influenza vaccine strains: Recombinant antigens from 2015-2023

Image Credit: Sino Biological Inc

Sino Biological provides recombinant flu antigen products under its ProVir™ viral antigen collection. The product line includes Neuraminidase (NA), Hemagglutinin (HA) and Nucleoprotein (NP) proteins, from all WHO-recommended vaccine strains in the past few years. Such antigens could be utilized to examine vaccine-induced antibody response.

Sino Biological has also come up with a huge collection of monoclonal antibodies against the flu antigens. Such reagents can help streamline appropriate assay development.

Source: Sino Biological Inc

Year 2022-2023

A/Victoria/2570/2019 (H1N1)
Recommended for Egg-based (quadrivalent,trivalent) Vaccine
HA: 40787-V08H, 40787-V08H1
NA: 40785-V08B
NP: 40774-V08B

 

A/Wisconsin/588/2019 (H1N1)
Recommended for Cell- or recombinant-based (quadrivalent, trivalent) Vaccine
HA: 40787-V08H, 40787-V08H1
NA: 40785-V08B
NP: 40774-V08B

 

B/Phuket/3073/2013
Recommended for Egg-based, Cell- or recombinant-based (quadrivalent) Vaccine
HA: 40498-V08B
NA: 40502-V07B
NP: 40500-V08B

 

A/Darwin/9/2021 (H3N2)
Recommended for Egg-based (quadrivalent, trivalent) Vaccine
HA: 40859-V08H, 40859-V08B
NA: 40860-V08B
NP: 40858-V08B

 

B/Austria/1359417/2021 (B/Victoria lineage)
Recommended for Egg-based, Cell- or recombinant-based (quadrivalent, trivalent) Vaccine
HA: 40862-V08H, 40862-V08B
NA: 40863-V08B
NP: 40861-V08B

 

A/Darwin/6/2021 (H3N2)
Recommended for Cell- or recombinant-based (quadrivalent, trivalent) Vaccine
HA: 40868-V08H, 40868-V08B
NA: 40869-V08B
NP: 40858-V08B

 

Year 2021-2022

A/Victoria/2570/2019 (H1N1)
Recommended for Egg-based (quadrivalent,trivalent) Vaccine
HA: 40787-V08H, 40787-V08H1
NA: 40785-V08B
NP: 40774-V08B

 

A/Wisconsin/588/2019 (H1N1)
Recommended for Cell- or recombinant-based (quadrivalent, trivalent) Vaccine
HA: 40787-V08H, 40787-V08H1
NA: 40785-V08B
NP: 40774-V08B

 

B/Washington/02/2019
Recommended for Egg-based, Cell- or recombinant-based (quadrivalent, trivalent) Vaccine
HA: 40722-V08H
NA: 40790-V08B
NP: 40755-V08B

 

B/Phuket/3073/2013
Recommended for Egg-based, Cell- or recombinant-based (quadrivalent) Vaccine
HA: 40498-V08B
NA: 40502-V07B
NP: 40500-V08B

 

A/Cambodia/E0826360/2020 (H3N2)
Recommended for Egg-based, Cell- or recombinant-based (quadrivalent, trivalent) Vaccine
HA: 40789-V08H, 40789-V08H1
NA: 40784-V08B
NP: 40778-V08B

 

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