Solid tumors: Target antigens for treatment

Initially developed to treat hematological malignancies, CAR-T therapy is currently being expanded to treat solid tumors by employing specialized CAR-T cells that attack specific antigens. Clinical trials are now underway to assess the efficacy of CAR-T cells that target GPC3, FAP, L1CAM, HER2, MSLN, CEACAM5, IL-13RA2, EpCAM, PSMA, and EGFR.

Third-generation HER2 CAR-T cells have been shown in studies to remove glioblastoma cells successfully, and their efficacy can be increased by combining them with PD-1 and CTLA-4 blockade.

Cytokines, such as IL4, TGF-beta, IL-2, IL-7, IL-10, IL-12, and IL-15, have also been linked to the therapeutic effects of CAR-T therapy. Sino Biological offers a wide range of reagents and services to aid in developing CAR-T treatments for solid tumors.

Solid tumors: Target antigens for treatment

Figure 1. CAR-T recognizes target antigens and kills tumor cells. Image Credit: Sino Biological Inc.

Featured recombinant proteins

Sino Biological provides high-quality recombinant proteins to aid in developing CAR-T treatments for solid tumors.

  • High-purity
  • Activity-validated
  • Low-endotoxin
  • Cited by researchers

Human EGFR protein Cat#: 10001-H08H. HPLC verified

Solid tumors: Target antigens for treatment

Purity: >90% as determined by HPLC. Image Credit: Sino Biological Inc.

Solid tumors: Target antigens for treatment

Immobilized human EGF protein (Cat#: 10605-H01H) can bind human EGFR protein.

Human IL13RA2 protein Cat#: 10350-H08H-B

Solid tumors: Target antigens for treatment

Immobilized human IL13 protein (Cat#: 10369-H01H) can bind human IL13RA2 protein. Image Credit: Sino Biological Inc.

Human HER2/ERBB2 protein Cat#: 10004-H08H. HPLC verified

Solid tumors: Target antigens for treatment

Ability to block anti-HER2 mediated inhibition of BT474 human breast ductal carcinoma cell proliferation. Image Credit: Sino Biological Inc.

Solid tumors: Target antigens for treatment

Immobilized human HER2/ERBB2 protein can bind Anti-HER2 antibody (Trastuzumab). Image Credit: Sino Biological Inc.

Human GPC3 protein Cat#: 10088-H08H 8 Citations

Solid tumors: Target antigens for treatment

Immobilized human GPC3 protein can bind to human bFGF/FGF2 protein. Image Credit: Sino Biological Inc.

More recombinant proteins (partial)

Table 1. Source: Sino Biological Inc.

Cat# Proteins Species Expression Host Purity Activity Tag
10464-H07H
   1 Citation
FAP Human HEK293 Cells ≥ 90 % (SEC-HPLC) Active His
10464-H07B
   1 Citation
Human Baculovirus-Insect Cells > 85 %   His
90879-C07H Cynomolgus HEK293 Cells > 90 %   His
10088-H02H2
   2 Citations
GPC3 Human HEK293 Cells > 95 % Active hFc
50989-M08B Mouse Baculovirus-Insect Cells > 95 % Active His
70265-D08H Canine HEK293 Cells ≥ 95 % (SEC-HPLC)   His
10004-H02H
   73 Citations
HER2 Human HEK293 Cells > 90 % Active hFc
10004-HCCH-B
   19 Citations
Human HEK293 Cells > 95 % Active  
10004-H20B1 Human Baculovirus-Insect Cells > 85 %   His & GST
50714-M02H
   8 Citations
Mouse HEK293 Cells > 90 % Active hFc
50714-M08H
   1 Citation
Mouse HEK293 Cells > 95 % Active His
70024-D08H Canine HEK293 Cells > 95 % Active His
80079-RCCH
   3 Citations
Rat HEK293 Cells > 92 %    
90020-K02H
   2 Citations
Rhesus HEK293 Cells > 90 % Active hFc
90020-K08H Rhesus HEK293 Cells > 90 % (SEC-HPLC) Active His
10140-H08H
   3 Citations
L1CAM Human HEK293 Cells > 85 %   His
50835-M02H Mouse HEK293 Cells ≥ 95 % (SEC-HPLC)   hFc
11077-H02H
   7 Citations
CEACAM5 Human HEK293 Cells ≥ 95 % (SEC-HPLC)   hFc
11077-H08H
   5 Citations
Human HEK293 Cells ≥ 95 % (SEC-HPLC)   His
54867-M02H1 Mouse HEK293 Cells ≥ 90 % (SEC-HPLC)   hFc
90891-C08H Cynomolgus HEK293 Cells ≥ 95 % (SEC-HPLC)   His
13128-H01H-B
   1 Citation
Mesothelin Human HEK293 Cells > 85 %   hFc
13128-HNCH Human HEK293 Cells ≥ 95 % (SEC-HPLC)    
5A0830-M08H Mouse HEK293 Cells ≥ 95 % (SEC-HPLC)   His
10350-H03H
   4 Citations
IL13RA2 Human HEK293 Cells > 75 % Active His & hFc
10350-H08H
   1 Citation
Human HEK293 Cells > 85 % Active His
50061-M03H Mouse HEK293 Cells > 85 % Active His & hFc
70079-D02H
   1 Citation
 Canine HEK293 Cells > 95 % Active hFc
80204-R02H Rat HEK293 Cells > 90 % Active hFc
10694-H02H
   8 Citations
EpCAM Human HEK293 Cells > 95 %   hFc
10694-H08H
   1 Citation
Human HEK293 Cells ≥ 90 % (SEC-HPLC) Active His
50591-M08H
   7 Citations
Mouse HEK293 Cells > 95 %   His
90299-CCCH Cynomolgus, Rhesus HEK293 Cells > 85 %    
15877-H07H
   1 Citation
PSMA Human HEK293 Cells > 95 % Active His
50214-M07H Mouse HEK293 Cells > 88 %   His
10001-H02H
   20 Citations
EGFR Human HEK293 Cells > 85 % (SEC-HPLC) Active His
10001-H20B2
   11 Citations
Human Baculovirus-Insect Cells > 75 % Active His & GST
10001-H27H-B Human HEK293 Cells > 95 % (SEC-HPLC) Active His & AVI
51091-M08H
   2 Citations
Mouse HEK293 Cells > 85 % (SEC-HPLC) Active His
70026-D08B Canine Baculovirus-Insect Cells > 90 % Active His
80100-R08H
   2 Citations
Rat HEK293 Cells > 98 % Active His
90285-C08H Cynomolgus HEK293 Cells > 90 % (SEC-HPLC) Active His
90317-K08H Rhesus HEK293 Cells > 85 % Active His

 

Featured antibodies for target antigens

Sino Biological has created a panel of antibodies for cell therapy research in solid tumors, including IHC-P, ELISA, IP, FCM, and WB.

Anti-EpCAM antibody (Cat#: 10694-R028)

  • Type: Rabbit MAb
  • Ig Type: Rabbit IgG
  • Applications: WB, ELISA, IHC-P, FCM, ICC/IF, IP

Solid tumors: Target antigens for treatment

Immunochemical staining of human EpCAM in human bladder carcinoma. Image Credit: Sino Biological Inc.

Anti-L1CAM antibody (Cat#: 10140-R014)

  • Type: Rabbit MAb
  • Ig Type: Rabbit IgG
  • Applications: ELISA (Det), IHC-P, FCM, ICC/IF

Solid tumors: Target antigens for treatment

Flow cytometric analysis of human CD171 expression on HeLa cells. Image Credit: Sino Biological Inc.

Anti-EGFR antibody (Cat#: 10001-R021)

  • Type: Rabbit MAb
  • Ig Type: Rabbit IgG
  • Applications: ELISA, ELISA (Det), ICC/IF

Solid tumors: Target antigens for treatment

Immunofluorescence staining of Human EGFR in A431 cells. Image Credit: Sino Biological Inc.

Anti-CEACAM5 antibody (Cat#: 11077-R327)

  • Type: Rabbit MAb
  • Ig Type: Rabbit IgG
  • Applications: IHC-P

Solid tumors: Target antigens for treatment

Immunochemical staining of human CEACAM5 in human colon carcinoma. Image Credit: Sino Biological Inc.

More antibodies for target antigens (partial)

Table 2. Source: Sino Biological Inc.

Cat# Antigen Species Clonality Ig Type Application
10464-T16 FAP Human Rabbit PAb Rabbit IgG ELISA
100393-R024
    2 Citations
GPC3 Human Rabbit MAb Rabbit IgG FCM, ICC/IF
10088-T16 Human Rabbit PAb Rabbit IgG ELISA
10004-R002
   7 Citations
HER2 Human Rabbit MAb Rabbit IgG ELISA, IHC-P, ICC/IF
10004-R002A Human Rabbit MAb Rabbit IgG ELISA, IHC-P, FCM, ICC/IF
10004-T60
   1 Citation
Human Rabbit PAb Rabbit IgG WB, ELISA, IHC-P, IP
10004-MM01
   11 Citations
Human Mouse MAb Mouse IgG2a ELISA
10004-MM03
   4 Citations
Human Mouse MAb Mouse IgG1 FCM, ICC/IF
10004-MM40 Human Mouse MAb Mouse IgG2b IHC-P
10140-R004
   1 Citation
L1CAM Human Rabbit MAb Rabbit IgG ELISA
10140-R014-F Human Rabbit MAb Rabbit IgG FCM
101901-T08 Mouse Rabbit PAb Rabbit IgG IHC-P
10140-MM01
   5 Citations
Human Mouse MAb Mouse IgG1 ELISA
11077-R061 CEACAM5 Human Rabbit MAb Rabbit IgG FCM
11077-RP01
   1 Citation
Human Rabbit PAb Rabbit IgG ELISA
11077-MM08 Human Mouse MAb Mouse IgG2a ELISA, IHC-P
13128-MM12 Mesothelin Human Mouse MAb Mouse IgG1 ELISA, IHC-P
10350-R018-F IL13RA2 Human Rabbit MAb Rabbit IgG FCM
10350-T16 Human Rabbit PAb Rabbit IgG ELISA
80204-T24 Human Rabbit PAb Rabbit IgG ELISA, IHC-P
10694-MM05
   6 Citations
EpCAM Human Mouse MAb Mouse IgG1 WB
10694-MM06-F
   1 Citation
Human Mouse MAb Mouse IgG1 FCM
10694-R028-A Human Rabbit MAb Rabbit IgG FCM
10694-T52 Human Rabbit PAb Rabbit IgG WB, ELISA,  IP
50591-R002 Mouse Rabbit MAb Rabbit IgG WB, ELISA, IHC-P
50591-R065 Mouse Rabbit MAb Rabbit IgG IHC-P
15877-T24 PSMA Human Rabbit PAb Rabbit IgG ELISA, IHC-P
15877-T26 Human Rabbit PAb Rabbit IgG ELISA, IHC-P, ICC/IF
201427-T10 Human Rabbit PAb Rabbit IgG IHC-P, ICC/IF
10001-R043 EGFR Human Rabbit MAb Rabbit IgG ELISA, ICC/IF
10001-RE01-F Human Rabbit MAb Rabbit IgG FCM
10001-REN01 Human Rabbit MAb Rabbit IgG Neutralization
10001-T48 Human Rabbit PAb Rabbit IgG WB, ELISA
10001-T24 Human Rabbit PAb Rabbit IgG ELISA, IHC-P
10001-MM01
   1 Citation
Human Mouse MAb Mouse IgG2b ELISA
10001-MM08T Human Mouse MAb Mouse IgG1 FCM, ICC/IF
10001-MM11 Human Mouse MAb Mouse IgG1 IHC-P

 

Cell therapy-related cytokines

  • TGF-β
  • IL2
  • IL4
  • IL7
  • IL12
  • IL15

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