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Carbonic anhydrases: Isoforms as therapeutic targets for cancer

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The bicarbonate and proton concentrations, which regulate the pH of the cell, are crucially regulated by carbonic anhydrases (CAs). This modulation is essential for cell survival and proliferation, In solid tumors, CA proteins IX and XII’s activity is inhibited by sulfonamide-based inhibitors and monoclonal antibodies.

These inhibitors and antibodies are performing well in clinical trials for cancer, including one that Memorial Sloan Kettering Cancer Center is launching this year that combines a CA IX inhibitor and Nivolumab.

There is also evidence of dysregulation of all other catalytically active isoforms of CA (I, II, III, IV, CAs VA-VB, CAs VI-VII, CAs XIII, and XIV) in various cancer types. Following further investigation, they might eventually be used as diagnostic and prognostic markers.

Carbonic anhydrases: Isoforms as therapeutic targets for cancer

(Reference: doi.org/10.3390/molecules26216380). Image Credit: Sino Biological Inc.

Sino Biological has developed high-quality proteins and antibodies to aid in the study of CA isoforms in cancers and other malignancies.

Recombinant carbonic anhydrase (CA) proteins

A collection of recombinant CA protein reagents has been created by Sino Biological to aid in the study of CA isoforms in cancer.

Mouse carbonic anhydrase IX protein (Cat#: 50660-M08H)

Carbonic anhydrases: Isoforms as therapeutic targets for cancer

Image Credit: Sino Biological Inc.

  • High purity: >95%
  • Validated activity: Esterase activity. The specific activity is >100 pmoles/min/μg
  • Citation: PubMed ID | 34806527

Human carbonic anhydrase IX protein (Cat#: 10107-H02H)

Carbonic anhydrases: Isoforms as therapeutic targets for cancer

Image Credit: Sino Biological Inc.

  • High purity: >90%
  • Validated activity: Esterase activity. The specific activity is >50 pmoles/min/μg
  • Citation: PubMed ID | 28498332

Human carbonic anhydrase XII protein (Cat#: 10617-H08H)

Carbonic anhydrases: Isoforms as therapeutic targets for cancer

Image Credit: Sino Biological Inc.

  • High purity: >97%
  • Validated activity: Esterase activity. The specific activity is >40 pmoles/min/μg
  • Citation: PubMed ID | 34806527, 21994143

More recombinant carbonic anhydrase (CA) proteins

Table 1. Source: Sino Biological Inc.

Cat# Cas Species Expression Host Purity Tag Activity
10478-H08E CA2 Human E. coli > 96 % C-His Esterase activity validated
50685-M08E CA2 Mouse E. coli > 96 % C-His Esterase activity validated
10503-H08E CA3 Human E. coli > 95 % C-His Esterase activity validated
50350-M08H CA4 Mouse HEK293 Cells > 98 % C-His Esterase activity validated
10500-H08E CA5A Human E. coli > 96 % C-His Esterase activity validated
12285-H08E CA5B Human E. coli > 97 % C-His Esterase activity validated
10469-H08E CA8 Human E. coli > 94 % C-His Esterase activity validated
10107-H02H CA9 Human HEK293 Cells > 90 % C-hFc Esterase activity validated
10107-H08H CA9 Human HEK293 Cells > 95 % C-His Esterase activity validated
50660-M08H CA9 Mouse HEK293 Cells > 95 % C-His Esterase activity validated
70028-D02H CA9 Canine HEK293 Cells > 90 % C-hFc Esterase activity validated
10687-H08H CA10 Human HEK293 Cells > 97 % C-His Esterase activity validated
10687-HCCH CA10 Human HEK293 Cells > 95 % C-cleavage Esterase activity validated
50768-M08H CA10 Mouse HEK293 Cells > 97 % C-His Esterase activity validated
10617-H08H CA12 Human HEK293 Cells > 97 % C-His Esterase activity validated
50014-M08H CA12 Mouse HEK293 Cells > 95 % C-His Esterase activity validated
10461-H08E CA13 Human E. coli > 96 % C-His Esterase activity validated
10458-H08H CA14 Human HEK293 Cells > 97 % C-His Esterase activity validated
50013-M08H CA14 Mouse HEK293 Cells > 95 % C-His Esterase activity validated

 

Antibodies for carbonic anhydrase (CA)

A collection of CA enzyme-targeting antibodies from Sino Biological have been created and can be used in ELISA, WB, FCM, and IHC tests.

Anti-CA IX antibody, rabbit PAb (Cat#: 10107-RP02)

Carbonic anhydrases: Isoforms as therapeutic targets for cancer

Immunochemical staining of human CA9 in human stomach tissue. Image Credit: Sino Biological Inc.

Anti-CA XII antibody (PE), mouse MAb (Cat#: 10617-MM07-P)

Carbonic anhydrases: Isoforms as therapeutic targets for cancer

Flow cytometric analysis of Human CA12 expression on MCF-7 cells. Image Credit: Sino Biological Inc.

Anti-CA XII antibody, rabbit PAb (Cat#: 50014-RP02)

Carbonic anhydrases: Isoforms as therapeutic targets for cancer

Immunochemical staining of mouse CA12 in mouse kidney tissue. Image Credit: Sino Biological Inc.

More antibodies for carbonic anhydrase (CA)

Table 2. Source: Sino Biological Inc.

Cat# Antigen Species Clonality Ig Type Application Label
10478-R001 CA2 Human Rabbit MAb Rabbit IgG WB, IP  
10478-R004 CA2 Human Rabbit MAb Rabbit IgG ELISA  
10478-RP01 CA2 Human Rabbit PAb Rabbit IgG ELISA  
10478-RP02 CA2 Human Rabbit PAb Rabbit IgG WB, ELISA, IP  
201408-T40 CA2 Human Rabbit PAb Rabbit IgG WB, IHC-P  
50685-R002 CA2 Mouse Rabbit MAb Rabbit IgG ELISA  
50685-R003 CA2 Mouse Rabbit MAb Rabbit IgG IHC-P  
50685-RP01 CA2 Mouse Rabbit PAb Rabbit IgG ELISA  
50685-RP02 CA2 Mouse Rabbit PAb Rabbit IgG WB, ELISA, IHC-P, IP  
10503-MM09 CA3 Human Mouse MAb Mouse IgG1 ELISA  
10503-R002 CA3 Human Rabbit MAb Rabbit IgG IHC-P  
10503-R006 CA3 Human Rabbit MAb Rabbit IgG WB, IP  
10503-RP01 CA3 Human Rabbit PAb Rabbit IgG ELISA  
10503-RP02 CA3 Human Rabbit PAb Rabbit IgG ELISA, IHC-P  
107383-T36 CA3 Mouse Rabbit PAb Rabbit IgG WB, IP  
10472-R039 CA4 Human Rabbit MAb Rabbit IgG ELISA, IHC-P  
10472-T16 CA4 Human Rabbit PAb Rabbit IgG ELISA  
50350-RP01 CA4 Mouse Rabbit PAb Rabbit IgG ELISA  
50350-RP02 CA4 Mouse Rabbit PAb Rabbit IgG IHC-P  
50350-T44 CA4 Mouse Rabbit PAb Rabbit IgG WB, IHC-P, IP  
10500-RP02 CA5A Human Rabbit PAb Rabbit IgG WB, ELISA  
12285-R008 CA5B Human Rabbit MAb Rabbit IgG IHC-P  
12285-R030 CA5B Human Rabbit MAb Rabbit IgG ELISA  
12285-RP01 CA5B Human Rabbit PAb Rabbit IgG ELISA  
12285-T18 CA5B Human Rabbit PAb Rabbit IgG ELISA, ICC/IF  
12285-T52 CA5B Human Rabbit PAb Rabbit IgG WB, ELISA, IP  
10469-MM09 CA8 Human Mouse MAb Mouse IgG2a ELISA  
10469-R008 CA8 Human Rabbit MAb Rabbit IgG WB, IP  
10469-RP01 CA8 Human Rabbit PAb Rabbit IgG ELISA  
10469-RP02 CA8 Human Rabbit PAb Rabbit IgG WB, ELISA, IP  
50767-R001 CA8 Mouse Rabbit MAb Rabbit IgG ELISA, ELISA (Det)  
50767-R001-H CA8 Mouse Rabbit MAb Rabbit IgG ELISA HRP
50767-R005 CA8 Mouse Rabbit MAb Rabbit IgG WB, IP  
50767-R057 CA8 Mouse Rabbit MAb Rabbit IgG ELISA (Cap)  
50767-RP01 CA8 Mouse Rabbit PAb Rabbit IgG ELISA  
50767-T60 CA8 Mouse Rabbit PAb Rabbit IgG WB, ELISA, IHC-P, IP  
10107-MM02 CA9 Human Mouse MAb Mouse IgG1 ELISA  
10107-R003 CA9 Human Rabbit MAb Rabbit IgG WB, ELISA, IP  
10107-R005 CA9 Human Rabbit MAb Rabbit IgG ELISA, IHC-P  
10107-R011 CA9 Human Rabbit MAb Rabbit IgG ELISA  
10107-R036 CA9 Human Rabbit MAb Rabbit IgG ELISA  
10107-R053 CA9 Human Rabbit MAb Rabbit IgG FCM  
10107-R053-F CA9 Human Rabbit MAb Rabbit IgG FCM FITC
10107-R053-P CA9 Human Rabbit MAb Rabbit IgG FCM PE
10107-RP01 CA9 Human Rabbit PAb Rabbit IgG ELISA  
10107-RP02 CA9 Human Rabbit PAb Rabbit IgG ELISA, IHC-P  
10107-T48 CA9 Human Rabbit PAb Rabbit IgG WB, ELISA  
50660-R001 CA9 Mouse Rabbit MAb Rabbit IgG IHC-P  
50660-RP01 CA9 Mouse Rabbit PAb Rabbit IgG ELISA  
50660-T24 CA9 Mouse Rabbit PAb Rabbit IgG ELISA, IHC-P  
70028-RP01 CA9 Canine Rabbit PAb Rabbit IgG ELISA  
70028-T52 CA9 Canine Rabbit PAb Rabbit IgG WB, ELISA, IP  
10687-MM04 CA10 Human Mouse MAb Mouse IgG1 ELISA  
50768-R018 CA10 Mouse Rabbit MAb Rabbit IgG ELISA  
50768-RP01 CA10 Mouse Rabbit PAb Rabbit IgG ELISA  
50768-RP02 CA10 Mouse Rabbit PAb Rabbit IgG WB, ELISA  
10617-MM04 CA12 Human Mouse MAb Mouse IgG1 ICC/IF
10617-MM07-F CA12 Human Mouse MAb Mouse IgG1 FCM FITC
10617-MM07-P CA12 Human Mouse MAb Mouse IgG1 FCM PE
10617-MM08 CA12 Human Mouse MAb Mouse IgG1 ELISA, ELISA (Det)  
10617-MM11 CA12 Human Mouse MAb Mouse IgG1 FCM  
10617-MM11-F CA12 Human Mouse MAb Mouse IgG1 FCM FITC
10617-MM11-P CA12 Human Mouse MAb Mouse IgG1 FCM PE
10617-RP02 CA12 Human Rabbit PAb Rabbit IgG WB, IHC-P  
50014-R001 CA12 Mouse Rabbit MAb Rabbit IgG ELISA  
50014-R003 CA12 Mouse Rabbit MAb Rabbit IgG ELISA  
50014-R012 CA12 Mouse Rabbit MAb Rabbit IgG ELISA, IHC-P  
50014-RP01 CA12 Mouse Rabbit PAb Rabbit IgG ELISA  
50014-RP02 CA12 Mouse Rabbit PAb Rabbit IgG ELISA, IHC-P  
10461-R103 CA13 Human Rabbit MAb Rabbit IgG ELISA  
10461-RP01 CA13 Human Rabbit PAb Rabbit IgG ELISA  
10461-RP02 CA13 Human Rabbit PAb Rabbit IgG WB, ELISA, IP  
10458-R004 CA14 Human Rabbit MAb Rabbit IgG WB, ELISA  
10458-R110 CA14 Human Rabbit MAb Rabbit IgG ELISA (Cap)  
10458-R515 CA14 Human Rabbit MAb Rabbit IgG ELISA, IHC-P, ICC/IF  
10458-RP01 CA14 Human Rabbit PAb Rabbit IgG ELISA  
10458-T16 CA14 Human Rabbit PAb Rabbit IgG ELISA  
10458-T60 CA14 Human Rabbit PAb Rabbit IgG WB, ELISA, IHC-P, IP  
50013-R033 CA14 Mouse Rabbit MAb Rabbit IgG ELISA  
50013-RP01 CA14 Mouse Rabbit PAb Rabbit IgG WB, ELISA  
50013-RP02 CA14 Mouse Rabbit PAb Rabbit IgG WB, ELISA  

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