Originally developed to treat blood cancer, cutting-edge CAR-T cells have made significant strides in treating autoimmune diseases like multiple sclerosis. As evidence of the potential growth of adoptive cell therapy beyond its original scope, trials are presently being conducted in the United States.
In several situations, such as the activation and proliferation of CAR-T and CAR-NK cells, cytokines are essential to the success of immune cell culture. Important cytokines like IL-2, IL-7, IL-15, and IL-21 are added to a particular culture medium for enriched immune cells. For instance, IL-2 increases interferon-γ, granzyme B, and perforin expression, stimulating the development and multiplication of terminal effector T cells.
T cells with strong expansion and survival capabilities are guided toward a less differentiated memory stem-like phenotype by IL-7 and IL-15. IL-21 enhances NK cells' ability to proliferate and carry out cytotoxicity.
Sino Biological has effectively produced a range of GMP-grade and premium-quality cytokines, including IL-2, IL-7, IL-15, and IL-21. The unwavering dedication to upholding rigorous quality standards distinguishes these cytokines as indispensable assets in advancing CAR-T and CAR-NK development.
Image Credit: Sino Biological US Inc.
Featured GMP-grade cytokines
- High Purity
- High Bioactivity
- High Stability
- High Batch to Batch Consistency
Human Interleukin-21/IL-21 protein: GMP-10584-HNAE
High Purity: ≥ 95 % as determined by SEC-HPLC & SDS-PAGE. Image Credit: Sino Biological US Inc.
Human Interleukin-7/IL-7 protein: GMP-11821-HNAE
High Purity: ≥ 95 % as determined by SEC-HPLC & SDS-PAGE. Image Credit: Sino Biological US Inc.
More immune cell culture-related cytokines
Source: Sino Biological US Inc.
| Cat# |
Cytokine |
Species |
Purity |
Activity |
Expressed Host |
| GMP-10139-HNAE |
IL-1B |
Human |
≥ 95 % ☑ |
Active |
E. coli |
| GMP-11846-HNAE |
IL-4 |
Human |
≥ 95 % ☑ |
Active |
E. coli |
| GMP-10360-HNAE |
IL-15 |
Human |
≥ 95 % ☑ |
Active |
E. coli |
| GMP-11821-HNAE-L |
IL-7 |
Human |
≥ 95 % ☑ |
Active |
E. coli |
| GMP-11848-HNAE |
IL-2 |
Human |
≥ 95 % ☑ |
Active |
E. coli |
| GMP-10602-HNAE |
TNF-α |
Human |
≥ 95 % ☑ |
Active |
E. coli |
| GMP-10602-HNAE-L |
TNF-α |
Human |
≥ 95 % ☑ |
Active |
E. coli |
| GMP-10360-HNCE |
IL15 |
Human |
≥ 95 % ☑ |
Active |
E. coli |
| GMP-11725-HNAE |
IFN-γ |
Human |
≥ 95 % ☑ |
Active |
E. coli |
| GMP-10452-HNAH |
OSM |
Human |
≥ 95 % ☑ |
Active |
HEK293
Cells |
| GMP-CT011-H08H |
IL12 |
Human |
≥ 95 % ☑ |
Active |
HEK293
Cells |
| GMP-10429-HNAH |
Activin A |
Human, Mouse, Rat,
Cynomolgus, Rhesus |
≥ 95 % ☑ |
Active |
HEK293
Cells |
| GMP-10015-HNAH |
GM-CSF/CSF2 |
Human |
≥ 95 % ☑ |
Active |
HEK293
Cells |
| GMP-11858-HNAE |
IL3 |
Human |
≥ 95 % ☑ |
Active |
E. coli |
| GMP-10605-HNAE |
EGF |
Human |
≥ 95 % ☑ |
Active |
E. coli |
| GMP-10210-HNAE-L |
FGF7 |
Human |
≥ 95 % ☑ |
Active |
E. coli |
| 11066-HNAH |
VEGF165 |
Human |
≥ 95 % ☑ |
Active |
HEK293
Cells |
| 10947-HNAE |
IL-10 |
Human |
≥ 90 % ☑ |
Active |
E. coli |
| GMP-10014-HNAE |
FGF2 |
Human |
≥ 95 % |
Active |
E. coli |
| GMP-10395-HNAE |
IL-6 |
Human |
≥ 95 % |
Active |
E. coli |
| 10804-HNAC |
TGF beta 1 |
Human, Rhesus,
Cynomolgus, Canine |
≥ 95 % |
Active |
CHO Stable
Cells |
| 11844-H08B |
IL-9 |
Human |
≥ 97 % |
Active |
Baculovirus-
Insect Cells |
| 13089-H08H |
IL-19 |
Human |
≥ 95 % |
Active |
HEK293
Cells |
| 13060-HNAE |
IL-20 |
Human |
≥ 95 % |
Active |
E. coli |
☑HPLC-verified
Note: Sino Biological, Inc. sells GMP grade products designed for research, manufacturing use or ex vivo use and not intended for human in vivo applications.
More related cytokines
Featured antibodies and ELISA kits
Anti-IL-2 antibody (FITC), rabbit mAb: (Cat#: 51061-R449-F)
Applications: FCM
Flow cytometric analysis of Mouse IL2 expression on BABL/c splenocytes. Image Credit: Sino Biological US Inc.
Human IL-2 ELISA kit: (Cat#: KIT11848)
Image Credit: Sino Biological US Inc.
- Standard curve for IL-2 quantification
- Sensitivity: 4.47 pg/mL
- Assay range: 18.75-1200 pg/mL
Anti-IL-21 antibody, rabbit pAb: (Cat#: 105972-T32)
Applications: WB
Image Credit: Sino Biological US Inc.
- Lane A: HL-60 Whole Cell Lysate.
- Lane B: Rat spleen tissue lysate.
- Lane C: Rat brain tissue lysate.
Human IL-7 ELISA kit: (Cat#: KIT11821)
Image Credit: Sino Biological US Inc.
- Standard curve for IL-7 quantification
- Sensitivity: 0.26 pg/mL
- Assay range: 5.47-350 pg/mL
Learn More about Cytokines for Cell Therapy Research