Introduction
Immune checkpoint proteins have attracted more and more attention over the past couple of years due to their role in cancer development. Researchers have discovered that tumor cells can ‘hijack’ the checkpoint pathways of these proteins to avoid attacks from the immune system.
Thus, many cancer specialists believe that disabling these checkpoints may help the body’s immune system fight off cancer cells.
As a result of the anti-tumor activity demonstrated by anti-CTLA4 and anti-PD1 monoclonal antibodies, researchers have expanded their investigations to include other immune checkpoint proteins that may lead to better cancer treatments. To support these research initiatives, ACROBiosystems provides customers with an exclusive immune checkpoint protein collection, which includes Fc-tagged, His-tagged, mouse Fc-tagged, Strep-tagged and tag-free proteins.
These proteins are available in human, mouse, rat, rabbit rhesus macaque and cynomolgus varieties to allow for a wider range of research applications. ACROBiosystems has confirmed the consistency and excellent performance of their proteins using a wide variety of assays.
Fluorescence-Activated Cell Sorting (FACS) Tested Immune Checkpoint Proteins
| Molecule |
Sign |
Species |
Tag |
| B7-2 |
CD6-H5257 |
Human |
C-Fc |
| CD6-H82F5 |
Human |
C-Fc&C-Avi |
| CD155 |
CD5-H5251 |
Human |
C-Fc |
| CD5-H82F6 |
Human |
C-Fc&C-Avi |
| CD5-H5254 |
Human |
C-mFc (mIgG2a) |
| CD40 |
CD0-H5253 |
Human |
C-Fc |
| DNAM-1 |
DN1-H52H6 |
Human |
C-10×His |
| DN1-H5257 |
Human |
C-Fc |
| DN1-H82F9 |
Human |
C-Fc&C-Avi |
| LAG-3 |
LA3-C5252 |
Cynomolgus |
C-Fc |
| LA3-H52Aa |
Human |
C-mFc (mIgG2a) |
| LA3-H82F3 |
Human |
C-mFc (mIgG2a) &C-Avi |
| OX40 |
OX0-H5224 |
Human |
C-10×His |
| OX0-H5255 |
Human |
C-Fc |
| OX0-H82F7 |
Human |
C-Fc&C-Avi |
| TN4-H82E4 |
Human |
C-Avi&C-6×His |
| OX0-H5252 |
Human |
C-mFc (mIgG2a) |
| OX40 Ligand |
OXL-H52Q8 |
Human |
N-6×His |
| OXL-H526x |
Human |
N-Fc |
| OXL-H5250 |
Human |
C-mFc (mIgG2a) |
| PD-1 |
PD1-H5257 |
Human |
C-Fc |
| PD1-H82F2 |
Human |
C-Fc&C-Avi&C-6×His |
| PD-L1 |
PD1-H5258 |
Human |
C-Fc |
| PD1-H82F3 |
Human |
C-Fc&C-Avi&C-6×His |
| PD1-H52A3 |
Human |
C-mFc (mIgG1) |
| PD-L2 |
PD2-H5251 |
Human |
C-Fc |
| PD2-H52A5 |
Human |
C-mFc (mIgG1) |
| SIRP alpha |
SIA-H5225 |
Human |
C-9×His |
| SIA-H5251 |
Human |
C-Fc |
| SIA-H52A8 |
Human |
C-mFc (mIgG1) |
| SIA-H5351 |
Human |
C-Fc |
| CDA-H82F2 |
Human |
C-Fc&C-Avi |
| TIGIT |
TIT-H5254 |
Human |
C-Fc |
| TIT-H52H3 |
Human |
C-10×His |
| TIT-H82F1 |
Human |
C-Fc&C-Avi |
| TIT-H82E5 |
Human |
C-Avi&C-10×His |
| TIT-H5253 |
Human |
C-mFc (mIgG2a) |