ACROBiosystem's Organoid Toolbox offers various products and services related to organoid culture and differentiation.
Applications
- Disease Modeling
- Drug Screening
- Drug Safety Evaluation
- Precision Medicine
- Developmental Studies
- Organ Transplantation
Cardiac organoid
Cardiac Organoid differentiation diagram. Image Credit: ACROBiosystems Inc
Product features
- Diverse Cell Types: Cardiomyocytes, smooth muscle cells, fibroblasts, and endothelial cells make up cardiac organoid, which has a complete cellular makeup like that of the heart.
- Rhythmic Function: Its regular, heart-like contractions make it possible to investigate physiological responses and assess therapies more realistically.
- Electrophysiological Activity: The cardiac organoid exhibits cardiac-like electrical activity, which makes it possible to study electrical signaling pathways and chemical effects.
- Compound Responsiveness: Cardiac organoids react to substances, which makes it easier to evaluate drugs for safety and efficacy and to conduct pharmacological research.
Product data
Cardiomyocyte marker expression in cardiac organoid.
Image Credit: ACROBiosystems Inc
Electrophysiological activity recorded in cardiac organoids with a silicon probe showed activity similar to that of a real heart.
Image Credit: ACROBiosystems Inc
Cerebral organoid
Cardiac Organoid differentiation diagram. Image Credit: ACROBiosystems Inc
Product features
- Matrigel-Free: Cerebral Organoid does not require a Matrigel, the experimental setting is made simpler and the possibility of confounding factors is reduced.
- Diverse Neural Cell Types: Its diverse neuronal and glial cell composition enables a more accurate depiction of the cellular makeup of the brain.
- Neuronal Electrophysiology: The examination of brain signaling and electrical patterns is made possible by the display of neuronal electrical activity on cerebral organoids.
Image Credit: ACROBiosystems Inc
Product data
Early-stage cerebral organoids (around 36 days) exhibit the expression of neuron progenitor cells (NESTIN) and neuron markers (TUJ1).
Long-term (99–119 days) cultivated brain organoids display cell markers for oligodendrocytes (OLIG2), mature neurons (MAP2), and astrocytes (GFAP).
More than 30 signal units have been found in recordings of brain organoids made with silicon probes. These signal units can be classified into several neuronal groups according to their waveform and PCA score.
Image Credit: ACROBiosystems Inc
Transcriptomic analysis of cerebral organoids of different culture days
Source: ACROBiosystems Inc
Cerebral organoids express markers of various neurons and astrocytes, including those for glutamatergic, dopaminergic, cholinergic, serotonergic, GABAergic neurons, as well as astrocytes and oligodendrocytes.