Vascular endothelial growth factors, or VEGFs, constitute a class of secreted polypeptides that exhibit angiogenic and mitogenic activities. Due to the significance of VEGFs and receptors in tumorigenesis, angiogenesis and neuroprotection, they are attractive targets for drug development.
The members of the VEGF family — VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, VEGF-F and PlGF — bind in particular patterns to three associated receptor protein tyrosine kinases, namely, VEGFR1/FLT1, VEGFR2/KDR and VEGFR3/FLT4.
They also bind in specific patterns with neuropilin-1 (NRP1) and neuropilin-2 (NRP2) — two non-tyrosine kinase transmembrane proteins.
The ligand-receptor binding stimulates the formation of homomeric and heteromeric receptor complexes and triggers downstream signaling.
Apart from VEGF signaling, neuropilins also serve as co-receptors to various other signaling pathways, such as those induced by Hepatocyte Growth Factor (HGF), Epidermal Growth Factor (EGF), Platelet-Derived Growth Factor (PDGF), Fibroblast Growth Factor (FGF), Transforming Growth Factor beta (TGFβ) and Insulin-like Growth Factor (IGF).
VEGF family ligands and receptors
Sino Biological offers more than 65 recombinant VEGF and receptor proteins encompassing all members of the VEGF family and various isoforms of VEGF. A huge majority of these recombinant proteins are expressed in eukaryotic cells (insect cells or human cells), thereby ensuring accurate modification and higher activity of proteins.
High activity
Cell proliferation assay using human umbilical vein endothelial cells (HUVEC). Image Credit: Sino Biological Inc.
Inhibit the VEGF-dependent proliferation of human umbilical vein endothelial cells (HUVEC). Image Credit: Sino Biological Inc.
Recommended recombinant VEGF and receptor proteins
Source: Sino Biological Inc.
| Cat# |
Molecule |
Species |
Activity |
Tag |
| 10136-H02H |
VEGFR1/FLT-1 |
Human |
Active |
hFc |
| 10136-H08H |
VEGFR1/FLT-1 |
Human |
Active |
His |
| 10136-H08H1 |
VEGFR1/FLT-1 |
Human |
Active |
His |
| 10806-H02H |
VEGFR3/FLT4 (ECD) |
Human |
Active |
hFc |
| 50584-M02H |
VEGFR3/FLT-4 |
Mouse |
Active |
hFc |
| 10012-H02H |
VEGFR2/KDR |
Human |
Active |
hFc |
| 10012-H02H1 |
VEGFR2/KDR (Domain 1&2&3) |
Human |
Active |
hFc |
| 10012-H02H1-B |
VEGFR2/KDR (Domain 1&2&3) |
Human |
|
hFc |
| 10012-H02H2 |
VEGFR2/KDR (Domain 2&3) |
Human |
Active |
hFc |
| 10012-H08H2 |
VEGFR2/KDR (Domain 2&3) |
Human |
|
His |
| 10012-H20B1 |
VEGFR2/KDR |
Human |
Active |
GST &
His |
| 50998-M08H-B |
VEGFR2/KDR |
Mouse |
Active |
His |
| 80113-R02H |
VEGFR2/KDR |
Rat |
Active |
hFc |
| 80113-R08H |
VEGFR2/KDR |
Rat |
|
His |
| 90907-C08H |
VEGFR2/KDR |
Cynomolgus |
|
His |
| 10011-H08H |
NRP1 |
Human |
Active |
His |
| 10695-H02H |
NRP2 |
Human |
Active |
hFc |
| 11066-HNAB-B |
VEGF165 |
Human,
Cynomolgus |
|
Native |
| 11066-HNAH |
VEGF165 |
Human,
Cynomolgus |
Active |
Native |
| 63004-ZNAB |
VEGF165 |
Danio rerio
(zebrafish) |
Active |
Native |
| 70004-DNAH |
VEGF164 |
Canine |
Active |
Native |
| 80006-RNAB |
VEGF164 |
Rat |
Active |
Native |
| 10544-H01H |
VEGFB |
Human |
Active |
hFc |
| 80103-R01H |
VEGFC (aa 108-223) |
Mouse, Rat |
Active |
hFc |
| 80103-R08H |
VEGFC (aa 108-223) |
Mouse, Rat |
Active |
His |
| 50157-M01H |
VEGFD |
Mouse |
Active |
hFc |
| 50157-M08H |
VEGFD |
Mouse |
Active |
His |
| 80104-R01H |
VEGFD |
Rat |
Active |
hFc |
| 10274-H05H |
PIGF |
Human |
Active |
mFc |
- VEGFA
- VEGFB
- VEGFC
- VEGFD
- PIGF
- VEGFR1/FLT-1
- VEGFR2/KDR
- VEGFR3/FLT-4
- NRP1
- NRP2
VEGF/VEGFR antibodies
Sino Biological has formulated more than 100 antibodies against VEGF and receptor proteins. These antibodies exhibit validated activities in different applications, such as ELISA, flow cytometry, immunohistochemistry, western blotting, immunofluorescence and neutralization. Sino Biological also offers ELISA kits and ELISA pair sets.
Antibody list of CSFs and CSFR
- Anti-VEGFA
- Anti-VEGFC
- Anti-VEGFD
- Anti-PIGF
- Anti-VEGFR1/FLT-1
- Anti-VEGFR2/KDR
- Anti-VEGFR3/FLT-4
- Anti-NRP1
- Anti-NRP2
About Sino Biological Inc.
Sino Biological is an international reagent supplier and service provider. The company specializes in recombinant protein production and antibody development. All of Sino Biological's products are independently developed and produced, including recombinant proteins, antibodies and cDNA clones. Sino Biological is the researchers' one-stop technical services shop for the advanced technology platforms they need to make advancements. In addition, Sino Biological offers pharmaceutical companies and biotechnology firms pre-clinical production technology services for hundreds of monoclonal antibody drug candidates.
Sino Biological's core business
Sino Biological is committed to providing high-quality recombinant protein and antibody reagents and to being a one-stop technical services shop for life science researchers around the world. All of our products are independently developed and produced. In addition, we offer pharmaceutical companies and biotechnology firms pre-clinical production technology services for hundreds of monoclonal antibody drug candidates. Our product quality control indicators meet rigorous requirements for clinical use samples. It takes only a few weeks for us to produce 1 to 30 grams of purified monoclonal antibody from gene sequencing.
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